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Douglas Labs

Varitonin
by Douglas Labs
60 Vegetarian Capsules

Comprehensive Venous And Circulatory Support*

Our Price: $20.80

Varitonin capsules, provided by Douglas Laboratories, contain a synergistic blend of vitamin C, hesperidin methyl chalcone, and standardized extracts of horse chestnut, butcher’s broom, and gotu kola for comprehensive vascular support.*

FUNCTIONS
Vitamin C: Foremost among vitamin C’s (ascorbic acid) many biological functions is its role in capillary health. Vitamin C is essential for the synthesis of collagen and glycosaminoglycans, which are the building materials of all connective tissues, such as skin, blood vessels, tendons, joint cartilage and bone. Vitamin C is the required coenzyme for two groups of enzymes that catalyze the cross-linking of collagen fibers - lysyl hydroxylases and prolyl hydroxylases. As such, vitamin C is essential for capillary health.*

Vitamin C is among the most powerful antioxidants in humans and animals. It is a water-soluble, chain-breaking antioxidant that reacts directly with superoxide, hydroxyl radicals, and singlet oxygen. In addition, vitamin C interacts with glutathione and alpha-lipoic acid, and regenerates vitamin E. The antioxidant functions of vitamin C appear to have clinical significance in providing protection from free radical damage to the vasculature, as well as the eyes, lungs, blood and the immune system.*

Horse Chestnut (Aesculus hippocastanum): A multitude of phytochemicals contribute to the beneficial properties of horse chestnut, including a composite of triterpenoid saponin glycosides collectively known as aescin. Horse chestnut also contains numerous flavonoids, including quercetin and kaempferol, sterols, and tannins.*

Horse chestnut is widely recommended to promote the strength and integrity of the veins and capillaries. Numerous research studies have documented the beneficial effects of horse chestnut supplementation, finding it comparable to traditional measures for encouraging vascular health. Horse chestnut extract has been shown to reduce capillary permeability. Horse chestnut also enhances venous tone and promotes diuresis.*

Butcher’s Broom (Ruscus asculeatus): Physicians as far back as ancient Greece have recognized the beneficial properties of butcher’s broom. Scientists have since identified several active components of butcher’s broom, including triterpenes, steroid saponins, and sapogenins. Ruscogenin and neuroscogenin are two specific steroidal components responsible for the ability of butcher’s broom to constrict blood vessels. In addition to enhancing venous tone, butcher’s broom helps reduce capillary permeability. Butcher’s broom is frequently used in Europe in combination with hesperidin methyl chalcone and vitamin C to enhance vascular health.*

Gotu Kola (Centella asiatica): Several saponins, notably asiaticoside, make gotu kola a useful botanical extract for promoting vascular health. Gotu kola helps strengthen the microvasculature, which in turn enhances blood circulation to the legs. Gotu kola may also help prevent excess fluid retention in the lower extremities.*

Hesperidin Methyl Chalcone: Hesperidin methyl chalcone is a methylated derivative of the flavonoid hesperidin. Hesperidin methyl chalcone supports and protects the integrity of the vascular system with particular activity in the capillaries and veins. Hesperidin methyl chalcone has been shown to help strengthen capillaries by increasing capillary resistance and decreasing capillary permeability. Increased venous motility, tone, and the ability of vessels to dilate are also enhanced by hesperidin methyl chalcone.*

Supplement Facts Serving Size: One (1) Vegetarian Capsule Servings Per Container: 60

	Amount Per Serving	Daily Value
Vitamin C (As L-ascorbic Acid)	250 mg	417%
Horse Chestnut Seed (Aeculus Hippocatanum) dried extract, min. 20 percent saponins calculated as aescin	250 mg	**
Hesperidin (Methyl Chalcone)	125 mg	**
Gotu Kola (Centella asiatica) Leaf dried extract, min. 10 percent asiaticosides, min. 16 percent triterpenes	60 mg	**
Butcher's Broom Rhizome (Ruscus Asculeatus) dried extract, 10 percent saponins calculated as ruscogenins	50 mg	**

** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet.

Other Ingredients

Cellulose, Stearates (Vegetable Source)

Suggested Use

As a dietary supplement, one to two (1-2) capsules daily, or more as directed by a physician.

Warnings

No adverse effects have been reported. ... Keep out of reach of children. ... Store in a cool, dry place, away from direct light. ... Tamper resistant package, do not use if outer seal is missing.

Applicable Functions

Blood Coagulation, Blood Pressure Normalization, Blood Strength, Blood Viscocity, Cardiovascular Health, Eye Health, Immune System Support, Urinary, Varicose Ulcers, Varicose Veins

Related Structure Groups

Blood, Capillary, Circulatory system, Collagen, Eye, Eyeball, Immune System, Lung, Ureter, Urethra, Urinary Tract, Vascular, Vein, Vessel

REFERENCES

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Arpaia MR, Ferrone R, Amitrano M, et al. Effects of Centella asiatica extract on mucopolysaccharide metabolism in subjects with varicose veins. International Journal of Clinical Pharmacology Research 1990;10:229-33.

Belcaro GV, Rulo A, Grimaldi R. Capillary filtration and ankle edema in patients with venous hypertension treated with TTFCA. Angiology 1990;41:12-8.

Bendich A, Langseth L. The health effects of vitamin C supplementation: A review. J Am Coll Nutr 1995;14:124-136.

Bisler H, Pfeifer R, Kluken N, Pauschinger P. [Effects of horse-chestnut seed extract on transcapillary filtration in chronic venous insufficiency] Deutsche Medizinische Wochenschrift 1986;111:1321-9.

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Cesarone MR, Laurora G, De Sanctis MT, et al. [The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study]. Minerva Cardioangiol 1994;42:299-304.

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Diehm C, Vollbrecht D, Amendt K, Comberg HU. Medical edema protection – clinical benefit in patients with chronic deep vein incompetence. A placebo-controlled double blind study. Vasa 1992;21:188-92.

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Frei B. Reactive oxygen species and antioxidant vitamins: Mechanisms of action. Am J Med 1994;97 Suppl. 3A:5S-13S.

Greeske K, Pohlmann BK. [Horse chestnut seed extract – an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency]. Fortschritte Der Medizin 1996;114:196-200.

Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. A criteria-based systematic review. Arch Dermatol 1998;134:1356-60.

Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiology 1987;38:46-50.

Rudofsky G. [Improving venous tone and capillary sealing. Effect of a combination of Ruscus extract and hesperidine methyl chalcone in healthy probands in heat stress]. Fortschr Med 1989;107:55-8.

Svensjo E, Bouskela E, Cyrino FZ, Bougaret S. Antipermeability effects of Cyclo 3 Fort in hamsters with moderate diabetes. Clin Hemorheol
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Takegoshi K, Tohyama T. Okuda K, et al. A case of Venoplant-induced hepatic injury. Gastroenterol Jpn 1986;21:62-5.

Weindorf N, Schultz-Ehrenburg U. [Controlled study of increasing venous tone in primary varicose veins by oral administration of Ruscusaculaeatuys and trimethylhesperidinchalcone]. Z hautkr 1987;62:28-38.