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Ultra Guggulow
by Doctors Best
90 Tablets
Helps Maintain Normal Healthy Cholesterol And Triglyceride Levels*
Our Price: $14.76
Retail Price: $29.99
You Save: $15.23 each, a 51% Savings! | 
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Ultra Guggulow supplies a standardized extract of gum guggul resin (Gugulipid), an herb derived from the Commiphora mukul tree in India. Gugulipid is standardized at 2.5% guggulsterones, which are active ingredients present in the resin. Bioperine promotes absorption of nutrients in the GI tract.* Gum Guggul
Gum guggul is related to myrrh gum and also to Boswellia serrata, another resinous herb prominent in the Ayurvedic materia medica. Gum guggul, often referred to simply as “guggul,” has been used in the Ayurvedic herbal tradition since at least 600 B.C. The herb is mentioned in the Vedas, the Holy Scriptures of India, which are estimated to date back anywhere from 3,000 to 10,000 years. Modern investigation into gum guggul began in 1964, with a series of tests conducted by G.V. Satyavati. The inspiration for this research is an Ayurvedic treatise written in Sanskrit that describes in detail a condition called “coating and obstruction of channels.” Impressed by the apparent analogy to the cardiovascular system, Satyavati and others initiated a series of tests to determine if gum guggul, which was mentioned in the treatise, would have any effect on blood lipid levels. This set the stage for an extensive series of studies on gum guggul’s pharmacology and clinical effects. Guggulsterones
Systematic analysis of gum guggul resin carried out by Indian researchers in the 1980s identified the active ingredients as a group of lipid-based compounds called guggulsterols and guggulsterones. It was determined that two members of this group,Z-guggulsterone and E-guggulsterone, are largely responsible for the herb’s effect on cholesterol and blood fats. An extract standardized for guggulsterone content of gum guggul was then developed by the CDRI in Lucknow, India. This extract, called “Gugulipid,” is now the preferred form of gum guggul for use in clinical studies. Ultra Guggulow contains Gugulipid, standardized to supply 25 mg of guggulsterones per 1,000 mg of extract.* Bioperine
Traditional Ayurvedic herbal formulas often include black pepper and long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is piperine, an alkaloid. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.*
Bioperine contains 95% piperine extracted from the fruits of black pepper. Several double-blind clinical studies have confirmed that Bioperine increases absorption of nutrients.* Helps Maintain Normal Healthy Cholesterol Levels
The research of gum guggul over the last 30 years has produced a wealth of evidence establishing this herb’s beneficial effect on cholesterol and blood fats. The preliminary studies carried out by Satyavati and her colleagues were done on rabbits fed hydrogenated vegetable oil to artificially elevate cholesterol levels. In contrast to non-treated test subjects, rabbits given gum guggul had normal cholesterol and blood lipid levels and healthy blood vessels.* A number of multicentric clinical trials have tested the efficacy of Gugulipid for maintaining normal cholesterol. The CDRI has conducted Phase 1 trials to establish the safety of the extract. Gugulipid has been found safe and free of unwanted effects on blood chemistry, liver function and the heart. Phase II trials confirmed Gugulipid’s effectiveness in normalizing total cholesterol, LDL, HDL and triglycerides.* SOD-Protecting, Antioxidant Action
In an animal study carried out by the CDRI, guggulsterones reversed the decrease in SOD (superoxide dismutase) activity that results from reduced blood flow to the heart. The researchers reported that “SOD was significantly protected by guggulsterone.” Increases in lipid peroxides (free-radical byproducts) and xanthine oxidase, an enzyme that produces oxygen free radicals, were also reversed. Although preliminary, these findings lend additional support to the use of Gugulipid for sustaining cardiovascular health.*
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Supplement FactsServing Size: One (1) Tablet
Servings Per Container: 90 | | | | Amount
Per Serving | Daily
Value | Gum Guggul Resin Extract
(Commiphora Mukul)
guggulsterones 25 mg | 1 g | ** | Black Pepper Fruit Extract
(Piper Negrum)
Bioperine: A patented standardized extract containing 95% piperine. | 5 mg | ** | |
** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet. |
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| Croscarmellose Sodium, Magnesium Stearate (Vegetable Source), Microcrystalline Cellulose, Silicon Dioxide, Stearic Acid (Vegetable Source) |
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| As a dietary supplement, one (1) tablet three (3) times daily with food, or more as directed by your healthcare practitioner. ... Note: For the first seven (7) days, one (1) tablet daily; two (2) tablets daily for the next seven (7) days; thereafter, three (3) tablets daily. |
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| Rare instances of rash have been reported. If this occurs, merely discontinue use. ... If pregnant or nursing, consult your healthcare provider before taking this, or any, supplement. ... Keep out of reach of children. ... Store in a cool, dry place. |
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| Doctors Best products do not contain milk, egg, wheat, yeast, corn, sugar, sweeteners, starch, salt, preservatives, waxes, coating or colors. Doctor's Best products are also GLUTEN FREE. |
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| Cardiovascular Health, Cell Vitality, Cellular Oxidation, Cholesterol Health, Free Radicals, Heart Health, High Cholesterol Reduction, Lipid Peroxidation |
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| Cardiovascular, Cell, Cellular Function, Heart |
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Q. Is Ultra Guggulow standardized to contain 25 mg of guggulsterones?
A. Yes, Ultra Guggulow contains an extract of the guggul herb that is standardized to contain 25 milligrams of "Z" and "E" guggulsterones in each 1,000 mg tablet.
Q. Is it normal for Ultra Guggulow to smell bad and/or taste bitter?
A. Yes. Guggulow, in its natural state, has a very pungent aroma and a bitter taste that can sometimes still be tasted despite the tablet coating.
Q. I ran out of Ultra Guggulow a week ago, do I have to re-start Ultra Guggulow as per the instructions on the label?
A. No. Because some people may be sensitive to guggulipid, it is suggested that the dosage be taken as recommended on the label as a means of determining whether they will have an adverse reaction to the Guggulow. If you have already taken the Ultra Guggulow and have not been sensitive to it, you may continue to use the Guggulow at your previous normal amounts.
Q. What is the source of the Ultra Guggulow coating? Is it derived from corn?
A. The coating on the Ultra Guggulow is plant derived. It comes from wood pulp and does not contain corn.
Q. Does guggulipid interact with other drugs?
A. Guggulipid has no known drug interactions. |
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We firmly believe that the integration of scientific research and traditional wisdom is how nutritional and herbal supplements will reach their exciting potential. Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Careful research and precise formula development keeps us at the leading edge of quality, effectiveness, and innovation. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Countless hours have been spent analyzing scientific literature to provide sound alternatives to the proliferation of questionable supplements in the marketplace. Each Doctor's Best product is accompanied by an annotated "Fact Sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with the FDA in accordance with DSHEA regulations. Traditional wisdom, up-to-date research, product quality you can trust: everything you need to develop smart strategies for achieving optimal health and well-being. We think you’ll agree that this combination of products and services is second to none. |
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Q. What are your capsules made of?
A. Doctor's Best capsules are typical gelatin capsules, with the exception of select products now available in veggie cap form. They are made of gelatin from cattle, like the familiar "Knox gelatin" sold in grocery stores.
The gelatin used to make Doctor's Best's capsules is manufactured in accordance with strict guidelines that ensure it is BSE-free. The FDA and the supplement industry approved these guidelines. The gelatin is made only from cattle living in non-BSE countries. All Doctor's Best capsules are in full compliance with the FDA's September 1997 industry guide, The Sourcing and Processing of Gelatin to Reduce the Potential Risk Posed by Bovine Spongiform Encephalopathy in FDA-Regulated Products for Human Use.
Q. How long does it take for a capsule to dissolve?
A. Approximately 30-45 minutes. For 2-piece gelatin capsule, the USP standard for maximum dissolution time is 45 minutes.
Q. How long does it take for a tablet to dissolve?
A. FDA Rules & Regulations require tablets to dissolve in 45 minutes or less. However, Doctor's Best sets its standards higher. They require that their tablets dissolve in 30 minutes or less. Every lot of products in tablet form is tested to verify that it dissolves in under 30 minutes.
Q. Can I find out how fast a capsule or tablet dissolves by dropping it in a glass of water or vinegar at home?
A. Testing dissolution times at home using vinegar is not an accurate way to learn what happens to capsules and tablets in your stomach. Because stomach acid is much stronger than vinegar, capsules and tablets dissolve much faster in the stomach than in a glass of water or vinegar. Also, the stomach continually "agitates" its contents, much like a washing machine does.
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Q. Who determines what the daily dosage should be? And how is this done?
A. A panel of scientists at The Natural Academy of Sciences performs extensive research, ongoing clinical studies and scientific testing in order to determine the RDI (Recommended Daily Intake).
Q. I see that Silicon Dioxide has been used as an excipient in some of your products. Should I be concerned?
A. Silicon Dioxide is a GRAS (Generally Recognized As Safe) food additive. Numerous studies have found the following:
The oral toxicity for humans would be greater than 350 grams in one dose based on allometric comparisons between the mice studied and humans.
A single dose of 2,500mg of amorphous polymeric silicon dioxide to human volunteers did not significantly raise the SiO2 excretion in the urine. This suggests poor absorption of silicon dioxide (Langendorf 1966).
Less than one one-hundredth (1/100th) of the dose was found in urine, suggesting extremely poor absorption (Langendorf 1966).
This would suggest that there is no scientific reason to eliminate silicon dioxide as an excipient at the very low levels found in dietary supplements.
Q. Why is silicon dioxide used as an excipient in Doctor’s Best products? Why are excipients used at all?
A. Silicon Dioxide is used as a flow agent to enable "sticky" substances to flow through the encapsulation equipment. If silicon dioxide were not used, other flow agents would have to be used which would actually increase the number of excipients found in a given product. Ideally, the fewer excipients used, the better.
Q. Is there a limit to how many vitamins can be taken safely in one day?
A. Our bodies need vitamins and minerals, and if taken in large amounts, vitamins and minerals can adversely affect health. Large amounts of anything can be toxic. Our best advice is to work with a nutritionally aware doctor and follow label directions. |
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1. Satyavati, G., “Gugulipid: a promising hypolipidaemic agent from gum guggul (Commiphora wightii).” Economic and Medicinal Plant Research 1991;5:47-82.
2. Satyavati, G., “Gum guggul (Commiphora mukul) — The success story of an ancient insight leading to a modern discovery.” Indian J. Med. Res. 1988;87:327-335.
3. Dev, S., “A modern look at an age-old Ayurvedic drug-guggulu.” Science Age 1987; July:13-18.
4. Atal, C.K., Zutshi, U., Rao, P.G., “Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs.” J. of Ethnopharmacology 1981;4:229-32.
5. “Bioperine — Nature’s Bioavailability-Enhancing Thermonutrient. Executive Summary.” 1996; Sabinsa Corporation, Piscataway, N.J.
6. Nityanand, S., Srivastava, J.S., Asthana, O.P., “Clinical trials with Gugulipid®.” J. Ass. Physicians of India 1989; 37(5):323-28.
7. Agarwal, R.C. et. al., “Clinical trial of Gugulipid — a new hypolipidemic agent of plant origin in primary hyperlipidemia.” Indian J. Med. Res. 1986;84:626-34.
8. “Gugulipid,” Drugs of the Future 1988;13(7):618-619.
9. Kaul, S., Kapoo, N.K., “Reversal of changes of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio-protective drugs in isoproterenol induced myocardial necrosis in rats.” Ind J. Exp. Biol. 1989; 27:625-27. |
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Our Price: $14.76
Retail Price: $29.99
You Save: $15.23 each, a 51% Savings! |
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