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Synergistic Glucosamine - MSM Formula by Doctors Best 180 Capsules
Maintains Healthy Joints And Connective Tissue*
Our Price: $9.39 Retail Price: $24.99 You Save: $15.60 each, a 62% Savings! | 
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Synergistic Glucosamine/MSM Formula contains pure, sodium-free, potassium-stabilized glucosamine sulfate, as confirmed by HPLC testing. This formula also contains pure LIGNISUL MSM (methylsulfonylmethane). Together, these compounds support joint function by providing essential nutrition for healthy cartilage and tissue.* Glucosamine sulfate is derived from the shells of ocean-growing shellfish. It is processed to remove all residues of protein and impurities, yielding pure glucosamine sulfate as the final material. LIGNISUL MSM is natural-source MSM derived from trees. A biological compound that occurs in the human body and in some foods, MSM is an excellent dietary source of bioavailable organic sulfur. Synergistic Glucosamine/MSM Formula also contains pure, corn-free ascorbic acid.* Glucosamine sulfate supports joint function bysupplying the body with dietary ingredients (glucosamine and sulfur) for building joint cartilage. Glucosamine, an amino sugar normally manufactured in cartilage, stimulates the production of cartilage components known as “glycosaminoglycans.” These substances are essential to the maintenance of sound joint structure, which in turn allows for normal joint function.* MSM, organic sulfur, is a structural mineral that maintains the strength of various tissues by forming sulfur “tie-bars” (sulfhydryl bonds) between connective tissue proteins. MSM supplies the body with nature’s original source of organic bioavailable sulfur.* Vitamin C is essential for the formation of collagen, the protein fiber that gives cartilage its structural strength.* Why is Potassium-stabilized Glucosamine Sulfate Preferable? In order for glucosamine sulfate to be processed for oral supplementation, it must be stabilized with either sodium or potassium. Either mineral works for this purpose. Potassium is preferable. Many people are on sodium-restricted diets, and the Standard American Diet tends to be high in sodium and low in potassium. What’s more, studies have found that people needing joint support are low in both salivary potassium and total body potassium.* Glucosamine Sulfate: A Solid Foundation of Clinical Evidence Glucosamine sulfate has been thoroughly researched over the last 20 years. Double-blind and open clinical trials convincingly demonstrate that oral glucosamine sulfate improves joint function.* In one large open trial, more than 1,200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. 252 physicians participated in this multi-center study. 95% of the subjects experienced greater joint comfort and increased mobility. The physicians reported “good” results in 59%, and “sufficient” results in 36%. The improvements lasted for up to three months after the glucosamine sulfate was discontinued.* Why the Human Body Needs MSM The human body requires a continuous supply of bioavailable sulfur, and MSM is one of the primary, organic, sulfur-containing molecules for use by living organisms. MSM occurs normally in tissues and body fluids. Scientists who have studied MSM in detail believe MSM is an absolute requirement for maintenance of healthy tissues and organ functions.* The research on MSM has led to the filing of several patents that cover numerous uses of MSM as a dietary ingredient for both humans and animals. Through these studies, it has been found that physical and psychological stress increases in the body when its MSM supply falls below minimum levels, resulting in a loss of normal organ function.* MSM supports joint and organ function by donating sulfur for formation of sulfur tie-bars that maintain the integrity of cartilage and other tissues. Based on clinical observations, MSM benefits the body in many ways, which include maintenance of healthy skin, hair, and nails, digestive system support, and immune support. MSM is as nontoxic to the body as water, and is therefore completely safe, even at high dosage levels.* Supplementation is Needed to Realize the Benefits of MSM Widespread in nature, MSM is found in a variety of foods, including fresh fruits and vegetables, raw milk, raw meat and raw fish. However, MSM is a volatile substance easily lost during cooking, pasteurization, food processing and storage. The average American diet thus supplies at best a marginal MSM intake, which may be inadequate to maintain the optimum MSM concentration in the body. The body’s MSM concentration is also believed to decline with increasing age.*
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NOTE: Oversized Product - slightly higher shipping cost Product - Special Shipping Required This product is heavier and/or bulkier than our standard products. As a result, our customary $5.40 standard shipping charge and our 'Free Shipping Over $100' offer does NOT apply to this product. Your actual shipping cost for this item MAY be slightly higher. You can determine the exact charge for your geographic location directly in our shopping cart. |
Supplement FactsServing Size: Two (2) Capsules Servings Per Container: 90 | | | | Amount Per Serving | Daily Value | Vitamin C (Ascorbic Acid) | 100 mg | 167% | Potassium (From Glucosamine Sulfate KCl) | 61 mg | 2% | Chloride (From Glucosamine Sulfate KCl) | 56 mg | 2% | Glucosamine (Sulfate KCl) Supplying sulfur 80 mg | 500 mg | ** | MSM (Methylsulfonylmethane) (LIGNISUL) Supplying sulfur 340 mg | 1 g | ** | | | Lignisul® MSM is a registered trademark of Halton Health, Inc. | ** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet. |
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| Cellulose, Gelatin Capsule, Magnesium Stearate (Vegetable Source) |
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| As a dietary supplement, two (2) capsules three (3) times daily with or without food, or more as directed by your healthcare practitioner. |
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| If pregnant or nursing, consult your healthcare provider before taking this, or any, supplement. ... Keep out of reach of children. ... Store in a cool, dry place. |
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| Doctors Best products do not contain milk, egg, wheat, yeast, corn, sugar, sweeteners, starch, salt, preservatives, waxes, coating or colors. Doctor's Best products are also GLUTEN FREE. ... CONTAINS SHELLFISH derivatives. |
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| Digestive Balance, Digestive Comfort, Immune System Support, Inflammation Nutrition, Joint Comfort, Joint Health, Joint Mobility, Joint Pain, Nail Integrity, Skin Conditions, Swollen Ankles, Swollen Joints, Torn Connective Tissue, Torn Ligaments |
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| Cartilage, Collagen, Connective Tissue, Digestive System, Hair, Immune System, Joints, Ligament, Nail, Skin |
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We firmly believe that the integration of scientific research and traditional wisdom is how nutritional and herbal supplements will reach their exciting potential. Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Careful research and precise formula development keeps us at the leading edge of quality, effectiveness, and innovation. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Countless hours have been spent analyzing scientific literature to provide sound alternatives to the proliferation of questionable supplements in the marketplace. Each Doctor's Best product is accompanied by an annotated "Fact Sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with the FDA in accordance with DSHEA regulations. Traditional wisdom, up-to-date research, product quality you can trust: everything you need to develop smart strategies for achieving optimal health and well-being. We think you’ll agree that this combination of products and services is second to none. |
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Q. What are your capsules made of? A. Doctor's Best capsules are typical gelatin capsules, with the exception of select products now available in veggie cap form. They are made of gelatin from cattle, like the familiar "Knox gelatin" sold in grocery stores.
The gelatin used to make Doctor's Best's capsules is manufactured in accordance with strict guidelines that ensure it is BSE-free. The FDA and the supplement industry approved these guidelines. The gelatin is made only from cattle living in non-BSE countries. All Doctor's Best capsules are in full compliance with the FDA's September 1997 industry guide, The Sourcing and Processing of Gelatin to Reduce the Potential Risk Posed by Bovine Spongiform Encephalopathy in FDA-Regulated Products for Human Use.
Q. How long does it take for a capsule to dissolve? A. Approximately 30-45 minutes. For 2-piece gelatin capsule, the USP standard for maximum dissolution time is 45 minutes.
Q. How long does it take for a tablet to dissolve? A. FDA Rules & Regulations require tablets to dissolve in 45 minutes or less. However, Doctor's Best sets its standards higher. They require that their tablets dissolve in 30 minutes or less. Every lot of products in tablet form is tested to verify that it dissolves in under 30 minutes.
Q. Can I find out how fast a capsule or tablet dissolves by dropping it in a glass of water or vinegar at home? A. Testing dissolution times at home using vinegar is not an accurate way to learn what happens to capsules and tablets in your stomach. Because stomach acid is much stronger than vinegar, capsules and tablets dissolve much faster in the stomach than in a glass of water or vinegar. Also, the stomach continually "agitates" its contents, much like a washing machine does.
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Q. Who determines what the daily dosage should be? And how is this done? A. A panel of scientists at The Natural Academy of Sciences performs extensive research, ongoing clinical studies and scientific testing in order to determine the RDI (Recommended Daily Intake).
Q. I see that Silicon Dioxide has been used as an excipient in some of your products. Should I be concerned? A. Silicon Dioxide is a GRAS (Generally Recognized As Safe) food additive. Numerous studies have found the following:
The oral toxicity for humans would be greater than 350 grams in one dose based on allometric comparisons between the mice studied and humans.
A single dose of 2,500mg of amorphous polymeric silicon dioxide to human volunteers did not significantly raise the SiO2 excretion in the urine. This suggests poor absorption of silicon dioxide (Langendorf 1966).
Less than one one-hundredth (1/100th) of the dose was found in urine, suggesting extremely poor absorption (Langendorf 1966).
This would suggest that there is no scientific reason to eliminate silicon dioxide as an excipient at the very low levels found in dietary supplements.
Q. Why is silicon dioxide used as an excipient in Doctor’s Best products? Why are excipients used at all? A. Silicon Dioxide is used as a flow agent to enable "sticky" substances to flow through the encapsulation equipment. If silicon dioxide were not used, other flow agents would have to be used which would actually increase the number of excipients found in a given product. Ideally, the fewer excipients used, the better.
Q. Is there a limit to how many vitamins can be taken safely in one day? A. Our bodies need vitamins and minerals, and if taken in large amounts, vitamins and minerals can adversely affect health. Large amounts of anything can be toxic. Our best advice is to work with a nutritionally aware doctor and follow label directions. |
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1. Vidal y Plana, R.R., Bizzarri, D., Rovati, A.L., “Articular cartilage pharmacology: I. In vitro studies on glucosamine and non-steroidal anti-inflammatory drugs.” Pharmacological Research Communications 1978; 10(6):557-569.
2. Siamopoulou, A. et. al. “Sialochemistry in juvenile chronic arthritis.” British Journal of Rheumatology 1989;28(5):383-5.
3. Syrjanen, S. et. al. “Salivary and serum levels of electrolytes and immunomarkers in edentulous healthy subjects and in those with rheumatoid arthritis.” Clinical Rheumatology 1986;5(1):49-55.
4. Sambrook, P.N., et. al. “Bone turnover in early rheumatoid arthritis.” 1. Biochemical and kinetic indexes. Annals of the Rheumatic Diseases 1985;44(9):575-9.
5. Macario , J. T., Rivera, I.C., Bignamini, A.A., “Oral glucosamine sulfate in the management of arthrosis: report on a multi-centre open investigation in Portugal.” Pharmatherapeutica 1982; 3(3):157-68.
6. Vaz, A.L., “Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulfate in the management of osteoarthrosis of the knee in out-patients.” Current Medical Research and Opinion 1982; 8(3):145-149.
7. Herschler, R. “Methylsulfonylmethane in dietary products.” United States Patent 4,616,039; Oct. 7, 1986.
8. Jacob, S., Herschler, R. “Introductory remarks: dimethyl sulfoxide after 20 years.” Annals of the New York Academy of Sciences 1983; 411:xiii-xvii.
9. Hardingham, T. “Proteoglycans: Their structure, interactions and molecular organization in cartilage.” Biochemical Society Transactions 1981;9(6):489-97.
10. Bland, J. H., Cooper, S.M. “Osteoarthritis: A review of the cell biology involved and evidence for reversibility. Management rationally related to known genesis and pathophysiology.” Seminars in Arthritis and Rheumatism 1984;14(2):106-133. |
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Our Price: $9.39 Retail Price: $24.99 You Save: $15.60 each, a 62% Savings! |

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