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Enzymatic Therapy

Sea Buddies Daily Multiple - Tropical Splash
by Enzymatic Therapy
60 Chewable Tablets

Delivers 25 Important Nutrients In Just One Tablet A Day*

Our Price: $7.77
Retail Price: $11.95
You Save: $4.18 each, a 35% Savings!

Sea Buddies Daily Multiple (Tropical Splash) delivers 25 important nutrients that your child needs each day for health and energy, in a base of natural antioxidant fruit extracts. It contains less sugar than any leading brand of chewable tablet, and comes in both Splashberry and Tropical Splash flavors that kids love.*

Many children don't eat as well as we'd like them to, and have nutritional gaps in their diets. Sea Buddies Daily Multiple can help fill those gaps. In fact, multivitamin supplementation has been demonstrated to significantly improve children's health status and school performance. Recommended for children aged 2 to 12.*

How Does It Work?
Although it is widely recognized that children require ongoing optimal nutrition, providing healthy and nutritious food for children can be challenging. Changes in family and community cultures have created unique societal demands. Busy family schedules frequently necessitate reliance on foods that are convenient and satisfying, but contain little nutritional value. Food served in school lunch programs often contributes a significant amount of sugar, salt, concentrated carbohydrates, and trans-fatty acids to children's diets every day.*

Consequently, many children's diets are nutritionally lacking. Children who are inadequately nourished may not perform to their highest ability in academics or athletics. They may experience increased susceptibility to illness. Current research demonstrates that food intake in early childhood is also causally linked to health-related problems later in life. This means that significant numbers of children are at high risk of developing nutrition related health problems, including coronary atherosclerosis and osteoporosis as they enter adulthood.*

Multivitamin supplementation has been demonstrated to significantly improve children's health status and school performance. However, children's multivitamins vary greatly in quality and formulation effectiveness. Many individual vitamins and minerals have strong tastes that children dislike. The use of large quantities of sugar, artificial sweeteners, and artificial flavors in an effort to mask the taste negate nutritional value. In fact, some children's multivitamins come in "gummy" and other candy forms that are known to significantly stick to children's teeth. These newly developed confectionery forms of multivitamins have been linked to the destruction of tooth enamel in children.*

Each Sea Buddies Daily Multiple (Tropical Splash) contains approximately one gram of sugar, the majority as fructose. In comparison, one medium apple contains 16 grams of sugar, also as fructose. Each Sea Buddies Daily Multiple contains vitamins, minerals, and fruit extracts that provide the nutrients children need with a taste that they will enjoy.*

Vitamin A (as beta carotene)
This important nutrient supports healthy vision, skin integrity, and bone growth. Vitamin A also helps support healthy cell reproduction, cell division, and cell differentiation.*

Vitamin C (ascorbic acid and as sodium ascorbate)
Vitamin C helps support healthy collagen formation, connective tissue, bone tissue, and dentin (tooth tissue). Vitamin C also supports healthy skin integrity, healthy immune system function, provides protection from free radicals (by-products of the body's metabolism) and supports the healthy absorption of iron.*

Calcium (from tricalcium phosphate)
Tricalcium phosphate provides both calcium and phosphorus, major constituents of the bone matrix. Calcium supports healthy bone development and the integrity and strength of bone. This important mineral also supports healthy nervous system impulse transmissions and iron metabolism. Sufficient vitamin D is required for calcium absorption.*

Iron (as ferrous fumarate)
Iron supports the formation of hemoglobin and myoglobin, red blood cell carriers of oxygen to all body cells. Iron is also a component of many important proteins and enzymes in the body. The ferrous fumarate form of iron has high bioavailability and solubility.*

Vitamin D (as cholecalciferol)
The major function of vitamin D is to support healthy blood levels of calcium and phosphorus. Vitamin D supports healthy absorption of calcium in the formation and maintenance of strong bones.*

Vitamin E (as d-alpha tocopheryl acid succinate)
D-alpha tocopheryl acid succinate is the natural form of vitamin E. Vitamin E's antioxidant properties protect against free radicals. It supports healthy low-density lipid (LDL) cholesterol metabolism and healthy blood vessel walls. Vitamin E also supports healthy immune system function and the health of the lens of the eye.*

Vitamin K (as phytonadione)
Vitamin K supports the healthy synthesis of prothrombin, a crucial blood-clotting component. It also supports the healthy carboxylation (formation) of osteocalcin, a protein that helps prevent bone loss.*

Thiamin (as thiamin mononitrate)
This B vitamin helps support healthy nerves and muscles, including the heart. Thiamine also helps support the healthy metabolism of carbohydrates.*

Riboflavin
Another member of the B vitamins, riboflavin helps support the healthy metabolism of fats, proteins, and carbohydrates. Riboflavin also supports the health of skin, nails, and hair.*

Niacin (as niacinamide)
Niacin helps support healthy cholesterol levels that are already within normal limits, and raises beneficial high density lipoprotein (HDL) cholesterol.*

Vitamin B6 (as pyridoxine HCl)
This water-soluble vitamin supports production of hemoglobin and antibodies. Vitamin B6 also helps support the healthy conversion of stored carbohydrates or other nutrients to glucose to maintain normal blood sugar levels.*

Folic Acid
Folic acid supports the healthy production and maintenance of new cells, especially important during periods of rapid cell division and growth such as is childhood. Folic acid supports healthy deoxyribonucleic acid (DNA) replication and ribonucleic acid (RNA) transcription. Folic acid also supports the production of red blood cells, and supports blood sugar and amino acid utilization.*

Vitamin B12 (as cyanocobalamin)
This B vitamin helps support the production of red blood cells. Vitamin B12 also supports the health of the nervous system.*

Biotin
Another member of the B vitamin family, biotin supports the health of hair and skin.*

Pantothenic Acid (as calcium D-pantothenate)
This B vitamin supports the healthy metabolism of glucose and fats into energy. Pantothenic acid also supports healthy adrenal gland function and the healthy synthesis of antibodies.*

Phosphorus (from tricalcium phosphate)
Tricalcium phosphate provides both calcium and phosphate for healthy bones and teeth. Phosphorus supports a healthy acid-base balance (pH). It also supports healthy heart and kidney function, and nerve impulse transmission.*

Magnesium (as magnesium oxide)
This mineral supports the healthy metabolism of vitamin C and calcium. Magnesium also supports healthy cardiovascular activities, blood sugar metabolism, and muscle functioning.*

Selenium (as L-selenomethionine)
Working synergistically with vitamin E, selenium protects cells against the effects of free radicals produced during normal oxygen metabolism. Selenium also supports the healthy development of reproductive organs in boys.*

Manganese (as manganese citrate)
Manganese supports healthy fat and protein metabolism, thyroid function, blood sugar control, and normal skeletal growth.*

Chromium (as chromium picolinate)
Chromium supports healthy carbohydrate metabolism. Chromium is a component of GTF (glucose tolerance factor) and supports healthy blood sugar control mechanisms.*

Cherry (Prunus cerasus) Fruit Extract
Cherry fruit extract contains several antioxidant compounds.*

European Elder (Sambucus nigra) Berry Extract
Elder berry supports healthy immune system responses.*

Bilberry (Vaccinium myrtillus) Fruit Extract
Bilberries contain antioxidant effects and support healthy immune system responses, vision health, and healthy collagen.*

Cranberry (Vaccinium macrocarpon) Fruit Extract
Cranberry supports urinary health and immune health responses.*

Enzymatic Therapy, Inc. is an FDA-registered Drug Establishment and an AFSII-certified producer of particular organic products.

Supplement Facts Serving Size: Two (2) Tablets Servings Per Container: 30

	Amount Per Serving	Daily Value
Calories	10
Total Carbohydrate	3g	1%

Vitamin A (as retinyl acetate)	5,000 IU	100%
Vitamin C (ascorbic acid and as calcium ascorbate)	120 mg	200%
Vitamin D (as cholecalciferol)	400 IU	100%
Vitamin E (as d-alpha tocopheryl acid succinate)	30 IU	100%
Vitamin K (as phytonadione)	40mcg	50%
Thiamin (as thiamin mononitrate) (vitamin B1)	1.5 mg	100%
Riboflavin (vitamin B2)	1.7 mg	100%
Niacin (as niacinamide)	5 mg	25%
Vitamin B6 (as pyridoxine HCl)	1 mg	50%
Folic Acid	400 mcg	100%
Vitamin B12 (as cyanocobalamin)	6 mcg	100%
Biotin	150 mcg	50%
Pantothenic Acid (as calcium-D-pantothenate)	2.5 mg	25%
Calcium (from tricalcium phosphate)	100 mg	10%
Iron (as ferrous fumarate)	5 mg	28%
Phosphorus (from tricalcium phosphate)	50 mg	5%
Iodine (as potassium iodide)	150 mcg	100%
Magnesium (as magnesium oxide)	10 mg	3%
Zinc (as zinc ascorbate)	5 mg	33%
Selenium (as L-selenomethionine)	20 mcg	29%
Manganese (as manganese citrate)	1 mg	50%
Chromium (as chromium picolinate)	60 mcg	50%
Cherry Fruit Extract Sweet cherry (Prunus avium)	10 mg	**
European Elder Berry Extract (Sambucus nigra) 4:1	6 mg	**
Bilberry Fruit Extract (Vaccinium myrtillus) 4:1	2 mg	**
Cranberry Fruit Extract (Vaccinium macrocarpon) 12:1	2 mg	**
Stevia Leaf Extract (Stevia rebaudiana) 15:1	1 mg

Percent Daily Values are for children 4 and up. For children ages 2-<4, see bottle.

** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet.

Other Ingredients

Cellulose, Fructose, Magnesium Stearate, Malic Acid, Natural Flavor, Soybean Oil

Suggested Use

As a dietary supplement for children age two to four (2-4) years old: one-half (½) tablet daily, or more as directed by a healthcare practitioner. Children age four (4) years and over: one (1) tablet daily, or more as recommended by your healthcare practitioner.

Warnings

Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of the reach of children. In case of accidental overdose, call your physician or a Poison Control Center immediately. ... If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use. ... Keep bottle tightly closed.

Allergen Info

This product contains NO salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring or preservatives. This product contains natural ingredients; color variations are normal. ... CONTAINS soy derivatives.

Applicable Functions

Childhood Immune Health, Digestive Balance, Glucose Metabolism, Metabolism, Mineral Deficiency, Nutritional deficiencies, Vitamin Deficiency

Related Structure Groups

Cell, Cellular Function, Immune System, Metabolism Function

About Enzymatic Therapy

Nature Makes it Pure. Science Makes it Work.

Our People
Enzymatic Therapy sparks with an enthusiasm that comes from knowing we're helping create the best supplement products in the nation.

Our team is made up of people who are natural explorers, passionate about the healthful ingredients found in nature, but committed to finding the most pure and effective combinations backed by rigorous research.

This buzz doesn't just end at the lab door. Everyone here, from our staff of scientists to our crews running the pharmaceutical-grade machinery to our customer service professionals, shares the exuberance of helping improve the health of America one customer at a time.

Our Reputation
Enzymatic Therapy, Inc. is known as the highest quality provider of therapeutic-dosage natural healthcare products and nutritional supplements in the nation. We strive to be the best for your health.

Our Difference
One thing that sets us apart from the others is the way we make our products. Everything, including raw material evaluation, supplier selection, laboratory analysis and manufacturing standards, is set to conform to the FDA's verified Good Manufacturing Practices, known in the industry as "GMPs."

Our Brands

Quick Tips

Good health doesn't have to be complicated. There are plenty of common-sense steps we can all follow to live better, more active, and fuller lives.

Eat right
We hear this so often it almost loses meaning. Eating right should mean adding things to your diet--more veggies, more fruits, more rich-tasting high-fiber breads and grains. However, it doesn't necessarily mean you have to give up chocolate. After all, there's plenty of beneficial flavonoids in those dark chocolate bars, right? You may just not want to eat chocolate at every meal. Instead of swearing off your favorite (but not healthy) meal forever, try just cutting it down to once or twice a month--make it a treat. As you incorporate more healthy, whole foods into your diet, you'll probably find yourself craving them instead of the bad stuff.

Exercise daily
You don't have to run a marathon or lift your neighbor's house, but you can start parking a little further away at work each day. Begin taking break time walks, especially if the weather is nice. Dust off that bicycle and see if your friends would like to go for a spin. Almost every town has a dedicated group of folks who do some form of fun exercise. Whatever you do, don't overdo it right off the bat, and choose something you really enjoy. After a couple of weeks, your new exercise regimen will become part of your daily routine, as though it had always been that way.

Strength train your brain
Challenge yourself mentally, and not just by trying to keep up at work. Find a class in your off-hours that teaches something you've always been curious about, but has nothing to do with work. Read a book for fun. Start a board game night with your family. Check out those crossword puzzles. Research in recent years shows that learning new skills and interacting with the world keeps our minds younger much longer. You owe it to yourself to turn off the television and fire up some neurons!

Do something for others
Whether you volunteer for a local environmental group, a food pantry, or your church's annual picnic, people generally feel healthier when their focus is outside of themselves.

Drug Nutrient Interaction Chart References

Anti-anxiety

Miller LG. Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158:2200-2211. Abstract.
Spinella M, Eaton LA. Hypomania induced by herbal and pharmaceutical psychotropic medicines following mild traumatic brain injury. Brain Inj. 2002 Apr; 16(4):359-67. (see reference SSRIs)
Dannawi M. Possible serotonin syndrome after combination of buspirone and St. John's Wort J Psychopharmacol. 2002 Dec; 16(4):401. No abstract available.
Lilja JJ, Kivisto KT, Backman JT, et al. Grapefruit juice substantially increases plasma concentrations of buspirone. Clin Pharmacol Ther. 1998 Dec; 64(6):655-60.

Antibiotics

Breen GA. Hypoprothrombinemia associated with cefmetazole Ann Pharmacother. 1997 Feb 31 (2) :180-4.
Pelton R. LaValle JB. Drugs and Their Effects on Nutrition. In: The Nutritional Cost of Prescription Drugs. 2nd Edition Englewood, CO: Morton Publishing Company; 2004, 34-35.
Horowitz S. Combining supplements and prescription drugs. Altern Complete Ther. 2000.pp.306.
Brinker F. Vitamin/mineral/drug interactions. In:Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp.306
Foulds G, Hilligoss DM, Henery EB, Gerber N. The effects of an antacid or cimetidine on the serum concentrations of azithromycin. J Clin Pharmacol. 1991; 31:164-167. Abstract.
Flockhart DA, Desta Z, Mahal SK. Selection of drugs to treat gastro-oesophageal reflux disease: the role of drug interactions. Clin Pharmakinet. 2000 Oct;39 (4):295-309.

Anti-Diabetic

Nestler JE, Beer NA, Jakubowicz DJ, et al. Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone sulfate in nondiabetic men J Clin Endocrinol Metab. 1994 Mar;78(3):549-54.
Crave JC, Fimbel S, Lejeune H, et al. Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women. J Clin Endocrinol Metab. 1995 Jul; 80(7):2057-62.

Antihistamines

Izzo AA. Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence. Int J Clin Pharmacol Ther. 2004 Mar; 42(3):139-48.
Wang Z, Hamman MA, Huang SM, et al. Effect of St. John's Wort on the pharmacokinetics of fexofenadine. Clin Pharmacol Ther. 20002 Jun; 71(6):414-20.
Dresser GK, Bailey DG. The effects of fruit juices on drug disposition: a new model for drug interactions. Eur J Clin Invest. 2003 Nov; 33 Suppl 2:10-6.

Anti-Psychotics

Dursun SM, Oluboka OJ, Devarajan S, Kutcher SP. High-dose vitamin E plus Vitamin B6 treatment of risperidone-related neuroleptic malignant malignant syndrome. J Psychopharmacol. 1998; 12(2):220-1.
Javitt DC, Silipo G, Cienfuegos A, Shelley AM, et al. Adjunctive high-dose glycine in the treatment of schizophrenia. Int J Neuropsychopharmacol. 2001 Dec; 4(4):385-91.
Heresco-Levy U, Ermilov M, Lichtenberg P, Bar G, Javitt DC. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry. 2004 Jan 15;55(2):165-71.
Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry. 1999 Jan; 156(1):145-7.

Anti-Seizure

Brinker F, Vitamin/mineral/drug interactions In: Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp. 305.
Herbs Ibid. pp 27-42.

Benzodiazepines

Miller LG. Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158:2200-2211. Abstract.
Stevinson C, Huntley A, Ernst E. Systemic review of the safety of kava extract in the treatment of anxiety. Drug Saf 2002;25 (4) :251-61.
Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A enzyme. JAMA. 2003 Sep 17; 290(11):1500-4.

Beta-blockers

Gehr TW, Sica DA. Pharmacotherapy in congestive heart failure: Hyperkalemia in congestive heart failure. Congest Heart Fail. 2001 Mar-Apr; 7(2):97-100.
Rosa RM, Silva P, Young JB, et al. Adrenergic modulation of extrarenal potassium disposal. N Engl J Med. 1980 Feb 21; 302(8):431-4.
Bano G, Raina RK, Zutshi U, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol. 1991; 41(6):615-7.
Laer S, Neumann J, Scholz H. Interaction between sotalol and an antacid preparation. Br J Clin Pharmacol. 1997 Mar; 43(3):269-72.
Sasse M, Paul T, Bergmann P, et al. Sotalol associated torsades de pointes tachycardia in a 15-month-old child: successful therapy with magnesium aspartate. Pacing Clin Electrophysiol. 1998 May; 21(5):1164-6.
Forlani S, Moscarelli M, Scafuri A, et al. Combination therapy for prevention of atrial fibrillation after coronary artery bypass surgery: a randomized trial of sotalol and magnesium. Card Electrophysiol Rev. 2003 Jun; 7(2):168-71.

Calcium Channel Blockers

Haft JI, Habbab MA. Treatment of atrial arrhythmias. Effectiveness of verapamil when preceded by calcium infusion. Arch Intern Med. 1986;146:1085-89. Abstract.
Weiss AT, Lewis BS, Halon DA,et al. The use of calcium with verapamil in the management of supraventricular tachyarrhythmias. Int J Cardiol. 1983;4:275-80. Abstract.
Threlkeld DS, ed. Diuretics and Cardiovasculars, Calcium Channel Blocking Agents.In Facts and Comparisons Drug Information St. Louis, MO; Facts and Comparisons, Nov 1992, 150-150b.
Tannergren C, Engman H, Knutson L, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr; 75(4):298-309.
Bailey DG, Dresser GK, Kreeft JH, et al. Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. Clin Pharmacol Ther. 2000 Nov;68(5):468-77.
Baily DG, Arnold MD, Strong HA, Munoz C, Spence JD, et al. Effect of grapefruit juice and maringin on nisoldipine pharmacokinetics. Cli Pharmacol Ther.1993;54:589-94. Abstract

Diuretics, Potassium-Sparing

Devane J, Ryan MP. The effects of amiloride and triameterene on urinary magnesium excretion in conscious saline-loaded rats. Br J Pharmacol 1981;72:285-89

HIV Antivirals

Henderson L, Yue QY, Bergquist C, et al. St John's wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol. 2002 Oct;54(4):349-56. Review.
James JS. St. John's wort warning: do not combine with protease inhibitors, NNRTIs. AIDS Treat News. 2000 Feb 18 ;( No 337):3-5.
Piras G, Makino M, Baba M. Sho-saiko-to, a traditional Kampo medicine, enhances the anti-HIV-1 activity of lamivudine (3TC) in vitro. Microbiol Immunol. 1997; 41(10):835-9.
Moretti S, Famularo G, Marcellini S, et al. L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1-infected subjects treated with zidovudine and didanosine. Antioxid Redox Signal. 2002 Jun;4(3):391-403.
Lopez O, Bonnefont-Rousselot D, Edeas M, et al. Could antioxidant supplementation reduce antiretroviral therapy-induced chronic stable hyperlactatemia? Biomed Pharmacother. 2003 May-Jun; 57(3-4):113-6.
Patrick L. Nutrients and HIV: part three - N-acetylcysteine, alpha-lipoic acid, L-glutamine, and L-carnitine. Altern Med Rev. 2000 Aug;5(4):290-305. Review.
Gogu SR, Agrawal KC. The protective role of zinc and N-acetylcysteine in modulating zidovudine induced hematopoietic toxicity. Life Sci. 1996; 59(16):1323-9.
Gogu SR, Beckman BS, Rangan SR, Agrawal KC. Increased therapeutic efficacy of zidovudine in combination with vitamin E. Biochem Biophys Res Commun. 1989 Nov 30;165(1):401-7
Wang Y, Watson RR. Is vitamin E supplementation a useful agent in AIDS therapy? Prog Food Nutr Sci. 1993 Oct-Dec;17(4):351-75. Review.
de la Asuncion JG, del Olmo ML, Sastre J, et al. AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins. J Clin Invest. 1998 Jul 1; 102(1):4-9.

NSAIDs (non-steroidal anti-inflammatory drugs)

Sorenson JRJ. Copper chelates as possible active forms of the antiarthritic agents. J Medicinal Chem 1976;19:135-48.
Somova L, Zaharieva S, Ivanova M. Humoral factors involved in the regulation of sodium-fluid balance in normal man. II. Effects of indomethacin on sodium concentration, renal prostaglandins, vasopressin and renin-angiotensin-aldosterone system. Acta Physiol Pharmacol Bulg 1984;10:29-33.

Non-Narcotic Pain Relievers

Brinker F, Vitamin/mineral/drug interactions In: Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp. 183

Oral Contraceptives

Newhouse IJ, Clement DB, Lai C. Effects of iron supplementation and discontinuation on serum copper, zinc, calcium, and magnesium levels in women. Med Sci Sports Exerc. 1993 May; 25(5):562-71.
Milman N, Rosdahl N, Lyhne N, et al. Iron status in Danish women aged 35-65 years. Relation to menstruation and method of contraception. Acta Obstet Gynecol Scand. 1993 Nov; 72(8):601-5.
Frassinelli-Gunderson EP, Margen S, Brown JR. Iron stores in users of oral contraceptive agents. Am J Clin Nutr. 1985 Apr; 41(4):703-12.

Respiratory Corticosteroids

Smith BJ, Phillips PJ, Pannall PR, et al. Effect of orally administered beclomethasone dipropionate on calcium absorption from the gut in normal subjects. Thorax. 1993 Sep; 48(9):890-3.

Synthetic Thyroid

Beard JL, Borel M, Peterson FJ. Changes in iron status during weight loss with very low-energy diets. Am J Clin Nutr. 1997;66:104-110. Abstract.
Beard JL, Borel MJ, Derr J. Impaired thermoregulation and thyroid function in iron deficiency anemia. Am J Clin Nutr 1990;52:813-819. Abstract.
Campbell NR, Hasinoff BB. Iron supplements: A comon cause of drug interactions. Brit J Clin Pharmacol. 1991;31:251-255. Abstract.
Jabbar MA, Larrea J, Shaw RA. Abnormal thyroid function tests in infants with congenital hypothyroidism: The influence of soy-based formulas. J Am Coll Nutr 1997;16:280-282. Abstract.
Threlkeld DS, ed. Hormones, Thyroid Hormones. In: Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons; 1991:131-133c.

Sea Buddies Daily Multiple FAQ

Sea Buddies daily multiples come in two flavors: Splashberry and Tropical Splash. Why are the formulas and the daily dosages different?
Sea Buddies daily multiples were formulated in conjunction with Dr. Jeffery Bradstreet, a leading expert on the neurological development of children. Part of the goal of this supplement was to create great-tasting—yet health-promoting—chewable tablets that would provide essential vitamins, minerals, and fruit extracts for children aged two to twelve years.*

There are indeed two key differences between the Sea Buddies formulations. First, the serving size. In the original Splashberry formula, one tablet equals one serving. In the Tropical Splash formula, two tablets equal one serving. This larger serving size—although it provides the same amount of nutrients as the Splashberry formula--is simply due to additional natural flavors and 150 mcg of iodine (100% of the daily value).*

Iodine is found in many processed foods, and in iodized table salt. Because of this, the original Splashberry formula didn’t include it, and continues to remain iodine-free. However, Dr. Bradstreet recognized that there are many different dietary standards in American families, and wanted the Tropical Splash formulation to include the nutrient. Iodine is an important component for our bodies to make thyroid hormones and to support healthy metabolism. As a result, the formulations and serving sizes vary but both provide great-tasting options for nutritional support for children.*

Drug Nutrient Interactions

Prescription drug listings are not all-inclusive; the drugs listed below are common examples.

Top Drug Categories Interactions
Anti-anxiety
[Buspar (buspirone), Ativan(lorezepam) - see Benzodiazepines]
Kava - For reasons similar to benzodiazepines, it is recommended to avoid taking kava with buspirone unless otherwise directed by a licensed healthcare professional.
St. John's Wort, Ginkgo Biloba - Concurrent use of St. John's Wort and buspirone and St. John's Wort and Ginkgo Biloba with buspirone has resulted in mild serotonin syndrome and should be avoided unless directed by a licensed healthcare professional.
Grapefruit Juice - Concomitant administration of buspirone and grapefruit juice should be avoided as it has increased the concentration of buspirone in the blood.
Antibiotics
(General) Vitamin K - The use of cefmetazole sodium has been associated with hypoprothrombinemia and treated with Vitamin K supplementation.
Antibiotics

(Aminoglycosides, Cephalosporins, Macrolides, Penicillins, Quinolones, Sulfonamides, Tetracyclines) Calcium, Iron, Magnesium, and Zinc - May prevent the absorption of tetracycline, ciproflaxin, and other antibiotics.
Antibiotics

Gentamycin and Penicillians Potassium Chloride - Concomitant administration of gentamycin with potassium chloride may lower the absorption of potassium chloride.
Antibiotics

Extended spectrum Macrolides [Biaxin(clarithromycin), Zithromax (azithromycin), Erythromycin, and Tetracyclines] Antacids - Antacids containing magnesium and aluminum have been shown to interfere with azithromycin absorption. People can avoid this by taking azithromycin two hours before or after any aluminum or magnesium containing products. Studies show that the magnesium typically found in supplements affects absorption of azythromycin.
Anti-Diabetic
[Glucophage(metaformin), Actos, Avandia(pioglitazone)] DHEA(Dehydroepiandrosterone) - Metaformin has been shown to increase levels of DHEA in blood.
Antihistamines

[Claratin(loratadine), Allegra(fexofenadine)]
St. John's Wort - Concomitant use of St. John's Wort can have an effect on plasma levels of fexofenadine.
Fruit Juices - Co-administration of grapefruit, orange, and apple juices decreases the absorption of fexofenadine.
Anti-Psychotics
[Zyprexa(olanzapine), Risperdal(risperidone)]
Vitamin B6 and E - Reported to effectively treat risperidone-related neuroleptic malignant syndrome.*
Glycine - Glycine in combination with anti-psychotic treatment has shown significant results on the effectiveness of these drugs. While adjunctive glycine treatment has been shown to improve negative symptoms in combination with clozapine, olanzapine, and risperidone, additional studies have shown it to be ineffective in combination with clozapine.*
Supplementation with glycine in combination with an antipsychotic should only be done under the supervision of a healthcare professional.
Anti-Seizure

[Tegretol (carbamazepine), Dilantin(phenytoin), phenobarbital and Mysoline(primidone). Depakene(valproic acid) and Depakote(divalproex) are also anticonvulsant drugs.] Magnesium, Black Pepper, and Caffeine - Concomitant administration of phenytoin (Dilantin) or phenobarbital with magnesium oxide may lower magnesium oxide's absorption. Concomitant administration of Dilantin and black pepper and/or long pepper may cause the phenytoin to be absorbed more rapidly and eliminated more slowly. Phenytoin also increases the metabolism and loss of caffeine from the body.
Benzodiazepines
Kava - Due to the similarity of effects, it is usually recommended to avoid taking Kava with Benzodiazepines unless otherwise directed by a licensed healthcare professional.
St. John's Wort - Concomitant administration of St. John's Wort with alprazolam and should be avoided unless otherwise directed by a licensed healthcare professional.
Beta-Blockers Potassium - Concomitant use of certain Beta-Blockers may increase potassium levels.
Pepper (Piper Nigrum, Piper Longum) - In single dose human study, piperine, a chemical found in black pepper and long pepper, was reported to increase blood levels of propranolol, which could increase the activity and risks of the drug's side effects.
Antacids - One study showed a reduction in absorption of Sotalol (Betapace) when taken concomitantly with an aluminum oxide or magnesium hydroxide antacid. This interaction can be avoided by taking the medication two hours apart.
Magnesium - Magnesium has been effectively used to treat heart arrythmias that have resulted from administration of Sotalol (Betapace).*
Calcium Channel Blockers Calcium - High level calcium supplementation may reverse the blood pressure-lowering actions of some calcium channel blocker drugs.
Vitamin D - Vitamin D may interfere with the effectiveness of verapamil.
St. John's Wort - A recent study showed that St. John's Wort decreased the bioavailability of R- and S-verapamil.
Fruit Juices - Ingestion of grapefruit, grapefruit juice, and grapefruit products has been shown to increase the adverse effects of calcium channel blockers or similar drugs.
Diuretics, Potassium-Sparing

[Amiloride, Aldactone(spironolactone), Dytac(triamterene)] Magnesium - Magnesium tends to be preserved.
HIV Antivirals St. John's Wort - St. John's Wort has been shown to speed up the elimination of indinavir, which may result in resistance to the drug. St. John's Wort should not be taken concomitantly with HIV Antivirals.
Sho-Saiko-To - This herbal medicine has been shown to enhance the antiviral activity of lamivudine.*
Carnitine - Depletion of Carnitine levels may be responsible for muscle and nerve damage in patients on Antiviral therapies. Carnitine supplementation is recommended.
Antioxidants - A small study showed a positive effect of antioxidant supplementation on hyperlactatemia (elevated levels of lactate in the systemic circulation) in patients on long-term Antiviral therapy.*
N-Acetyl Cysteine - Studies have shown that supplementation with NAC during Antiviral therapy may reduce AZT toxicity.*
Vitamins E and C - Supplementation with Vitamin E has shown to improve the efficacy of AZT and supplementation with Vitamins E and C may reduce AZT-related cellular damage.*
NSAIDs (non-steroidal anti-inflammatory drugs) Copper - Copper may enhance the anti-inflammatory effects of NSAIDs. Indomethacin may cause sodium and water retention.*
Non-Narcotic Pain Relievers
[Imitrex(sumitriptan), Ultram(tramadol)] St. John's Wort - Potential interactions may occur. Concomitant administration is not advised unless prescribed by a healthcare professional.
Oral Contraceptives St. John's Wort - Concomitant use of St. John's Wort and oral contraceptives may reduce the effectiveness of contraceptives and cause breakthrough bleeding.
Serum Iron and Copper - Oral contraceptive use has been associated with an increase in iron and copper levels.
Respiratory Corticosteroids Calcium - Calcium absorption was reduced following administration of oral beclomethasone (inhaler), a respiratory steroid similar to Flonase.
Synthetic Thyroid Iron and Soy - Iron supplements and soy products taken at the same time as thyroid hormone replacement may interfere with absorption. Thyroid hormone absorption is increased when taken on an empty stomach. Thyroid hormones should be taken an hour before eating, at the same time every day.

For support of overall health in any individual, the appropriate comprehensive age- and gender-specific multiple formula, flax oil, and multiple antioxidant formula are recommended. However, for a specific potential deficiency, individuals may add single ingredient supplements to assure repletion. It is important to consider the quality and bioavailability of vitamin and mineral supplements used for these purposes.*

Additional References

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