Saventaro by Enzymatic Therapy 30 UltraCaps Enhances Natural Immunity* Our Price: $10.73 Retail Price: $16.50 You Save: $5.77 each, a 35% Savings!
Saventaro is a standardized extract free of harmful levels of certain substances called tetracyclic oxindole alkaloids (or "TOAs") commonly found in traditional cat's claw extracts. POA cat's claw has been shown to support powerful components of a healthy immune system, including important T-cells.*
Benefits
Key Features
The powerful plants used in Saventaro come to us through the generosity of the Ashaninka people of Peru. In return, a percentage of the proceeds goes toward financial support for education, medical care and the vital protection of their rainforest lands.*
Saventaro is the only patented, clinically studied, and guaranteed cat's claw extract to benefit both the natural and acquired immune systems. It provides beneficial POAs, compounds that support the body's natural anti-inflammatory response. By modifying the immune system, Saventaro can help support a healthy range of motion.*
How Does It Work? Saventaro is a unique extract of Uncaria tomentosa that both enhances natural immunity and modifies the acquired immune system. To the Ashaninka Indians in the Central Peruvian rain forest where Saventaro is harvested, the pentacyclic alkaloid-chemotype of U. tomentosa is a beneficial plant that they call saventaro (saveshi=plant, antearo=potent).*
Saventaro is made from the root extract of U. tomentosa, which contains significantly higher total alkaloids than the bark. In addition, the root is the only part of the plant that contains an important pentacyclic oxindole alkaloid, isomitraphylline. The majority of research by IMMODAL on U. tomentosa has been done using standardized extracts, pure alkaloids, or standardized mixtures of alkaloids.*
In nature, U. tomentosa occurs in two distinct chemotypes (chemical composition): one containing pentacyclic oxindole alkaloids (POAs), and another containing tetracyclic oxindole alkaloids (TOAs). While chemotypes of a particular species may be visually indistinguishable, the chemical constituents and therefore the biological activity differ greatly. This makes it difficult and time consuming to ensure that the correct plant chemotype is harvested. IMMODAL has developed a proprietary process to determine, at harvesting time, if U. tomentosa is the POA or TOA chemotype. This process, which later includes HPLC, guarantees that Saventaro is TOA-free.*
Saventaro is guaranteed to contain only POAs, which possess immuno-modulating properties. In contrast, TOAs can affect the central nervous system, inhibit platelet aggregation, weaken the strength of heart contractions and adversely affect heart rate, lower blood pressure, and, in larger doses, paralyze respiration and produce irregular muscle contractions. The beneficial effects of POAs are antagonized/inhibited by TOAs if the two types are mixed.*
The Immune System
The natural immune response is the first line of defense that offers immediate protection against a variety of foreign substances. This can include skin and mucous membrane integrity, inflammation, fever, and an initial cellular response. The phagocytic cells (eg, macrophages and granulocytes) of the natural immune system play two key roles: they present antigens to the acquired immune system, and they directly engulf and destroy pathogens.*
Acquired immunity occurs throughout the lifetime of an individual as an adaptive response to infection by a pathogen. This specific immunity involves a cell mediated response and a humoral immune response. The cell mediated response, the second line of immune defense that follows natural immunity, relies on killer T cells to attack pathogens directly. Humoral immunity, the third and strongest line of immune defense, involves the production of antibodies (specific molecules of the humoral immune response that bind to and neutralize pathogens or prepare them for uptake and destruction by phagocytes) by B lymphocytes in response to a particular antigen (an invading substance capable of eliciting an immune response, particularly the generation of antibodies).*
The acquired immune response is considered specific because both the B and T lymphocytes bear very diverse receptors on their surfaces, each of which is specific for a particular antigen. When presented with an antigen, B lymphocytes differentiate into memory B cells (B cells that can remember the antigen and quickly respond to identical antigens in subsequent attacks) and plasma cells (B cells that release antibodies to help macrophages digest pathogens). The other type of lymphocyte, T cells, are further differentiated into helper T cells (CD4 or T4) and cytotoxic/killer T cells (CD8 or T8). Helper T cells help activate other cells (e.g., B cells and macrophages) in the immune response, while the cytotoxic T cells directly kill foreign cells.*
Stimulation by a pathogen induces an immature lymphocyte to become an active lymphoblast. In order for the immune system to generate sufficient and specific lymphocytes (B and T) to respond to these antigens, the lymphoblast proliferates and differentiates into specific lymphoycte cells able to secrete antibodies, in the case of B cells, or in the case of T cells, to destroy infected cells or activate other components of the immune system. These more differentiated (cells that are more mature and less aggressive than their poorly differentiated counterparts) lymphocytes then migrate through the endothelial cells at the sites of infection.*
Saventaro's Effect on the Natural Immune System
Saventaro's Effect on the Acquired Immune System
Research has shown that levels of resting and weakly activated B and T lymphocytes in vitro are significantly increased by the addition of POAs to human endothelial cells. This increase in B lymphocyte proliferation can result in an increased supply of antibodies. Enhanced proliferation of T4 lymphocytes can improve communication of the immune system as a whole and provide overall immune support. Increased proliferation of T8 lymphocytes can also support immune resistance to pathogens.*
Study results found that endothelial cells, in the presence of POAs, release the “endothelial lymphocyte-proliferation regulating factor" that decreases the proliferation of highly activated human B and T lymphoblasts in vitro (up to 90%). Inhibition of proliferation of highly activated B and T lymphoblasts plays a role in supporting a healthy immune system.*
Conversely, TOAs inhibit the ability of POAs to enhance the release of this immune modulating factor. Therefore, TOAs reduce the proliferation of lymphocytes and the inhibition of proliferation of lymphoblasts dose-dependently (by up to 100%) when POAs and TOAs are mixed. More specifically, as little as 1% TOA content in an U. tomentosa product causes a 30% reduction of the inhibitory effects of POAs on lymphoblasts. Due to this antagonistic immunological effect, strictly controlled and lab tested harvesting and manufacturing procedures are required to ensure that only TOA-free U. tomentosa raw materials are used.*
Other Effects of Saventaro Saventaro is safe for use by people with autoimmune diseases.*
Enzymatic Therapy, Inc. is an FDA-registered Drug Establishment and an AFSII-certified producer of particular organic products.
Additional Sizes Available
30 UltraCaps - Cat's Claw Root Extract 20 mg
90 UltraCaps - Cat's Claw Root Extract 20 mg
Supplement Facts Serving Size: One (1) UltraCap Amount Daily Cat's Claw Root Extract(POA Cat's Claw) (Uncaria tomentosa) (pentacyclic chemotype) (Saventaro brand) Root Extract standardized to contain 1.3 percent pentacyclic oxindole alkaloids (POAs) and to be free of tetracyclic oxindole alkaloids (TOAs) 20 mg ** Saventaro is a registered trademark of IMMODAL Pharmaka GmbH (Austria) and is made in the USA under license from IMMODAL. Protected by U.S. patents: 5,302,611; and 5,723,625. Additional patents pending.
** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet.
Calcium Carbonate, Cellulose, Magnesium Stearate, Silicon Dioxide, Vegetable Polysaccharide (Capsule) As a dietary supplement, one (1) UltraCap three (3) times daily for the first ten (10) days and one (1) UltraCap daily thereafter, or more as recommended by your healthcare practitioner. Saventaro should not be taken by those with organ or allogenic bone marrow transplants. This precaution is based on theoretical concerns and has not been seen in clinical studies.* ... Saventaro has not been studied in pregnant women; therefore, it is not recommended during pregnancy or nursing.* ... In general, Saventaro is well tolerated. There have been some reports of transient gastrointestinal upset at the beginning of treatment. ... Store at controlled room temperature, 59° to 86°F. This product contains NO sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial flavoring, preservatives or ingredients of animal origin. All colors used are from natural sources. Color variations are normal. Gastrointestinal Motility , Gastrointestinal Vitality , Immune Impairment , Immune System Support , Joint Health , Microbial Imbalances Digestive System , GI Tract , Immune System Nature Makes it Pure. Science Makes it Work.
Our People Our Reputation Our Difference Our Brands
Good health doesn't have to be complicated. There are plenty of common-sense steps we can all follow to live better, more active, and fuller lives.
Eat right
Exercise daily
Strength train your brain
Do something for others
Prescription drug listings are not all-inclusive; the drugs listed below are common examples.
Top Drug Categories Interactions Anti-anxiety [Buspar® (buspirone), Ativan® (lorezepam) - see Benzodiazepines] Kava - For reasons similar to benzodiazepines, it is recommended to avoid taking kava with buspirone unless otherwise directed by a licensed health care professional.St. John's Wort, Ginkgo Biloba - Concurrent use of St. John's Wort and buspirone and St. John's Wort and Ginkgo Biloba with buspirone has resulted in mild serotonin syndrome and should be avoided unless directed by a licensed health care professional.Grapefruit Juice - Concomitant administration of buspirone and grapefruit juice should be avoided as it increased the concentration of buspirone in the blood.
Antibiotics (General) Vitamin K - The use of cefmetazole sodium has been associated with hypoprothrombinrmia and treated with Vitamin K supplementation. Antibiotics (Aminoglycosides, Cephalosporins, Macrolides, Penicillins, Quinolones, Sulfonamides, Tetracyclines) Calcium, Iron, Magnesium, and Zinc - May prevent the absorption of tetracycline, ciproflaxin, and other antibiotics. Antibiotics Gentamycin and Penicillians Potassium Chloride - Concomitant administration of gentamycin with potassium chloride may lower the absorption of potassium chloride. Antibiotics Extended spectrum Macrolides [Biaxin® (clarithromycin), Zithromax® (azithromycin), Erythromycin, and Tetracyclines] Antacids - Antacids containing magnesium and aluminum have been shown to interfere with azithromycin absorption. People can avoid this by taking azithromycin two hours before or after any aluminum or magnesium containing products. Studies show the magnesium typically found in supplements affects absorption of azythromycin. Anti-Diabetic [Glucophage® (metaformin), Actos® , Avandia® (pioglitazone)] DHEA (Dehydroepiandrosterone ) - Metaformin has been shown to increase levels of DHEA in blood. Antihistamines [Claratin® (loratadine), Allegra® (fexofenadine)] St. John's Wort - Concomitant use of St. John's Wort can have an effect on plasma levels of fexofenadine.
Fruit Juices - Co-administration of grapefruit, orange, and apple juices decreases the absorption of fexofenadine.
Anti-Psychotics [Zyprexa® (olanzapine), Risperdal® (risperidone)] Vitamin B6 and E - Reported to effectively treat risperidone -related neuroleptic malignant syndrome.
Glycine - Glycine in combination with antiphychotic treatment has shown significant effects on the effectiveness of these drugs. While adjunctive glycine treatment has been shown to improve negative symptoms in combination with clozapine, olanzapine, and risperidone. Additional studies have shown it to be ineffective in combination with clozapine.
Supplementation with glycine in combination with an antipsychotic should only be done under the supervision of a health care professional.
Anti-Seizure [Tegretol® (carbamazepine), Dilantin® (phenytoin), phenobarbital and Mysoline® (primidone). Depakene® (valproic acid) and Depakote® (divalproex) are also anticonvulsant drugs.] Magnesium, Black Pepper, and Caffeine - Concomitant administration of phenytoin (Dilantin® ) or phenobarbital with magnesium oxide may lower magnesium oxide's absorption. Concomitant administration of Dilantin® and black pepper and/or long pepper may cause the phenytoin to be absorbed more rapidly and eliminated more slowly. Phenytoin also increases the metabolism and loss of caffeine from the body. Benzodiazepines Kava - Due to the similarity of effects, it is usually recommended to avoid taking Kava with Benzodiazepines unless otherwise directed by a licensed health care professional.St. John's Wort - Concomitant administration of St. John's Wort with alprazolam and should be avoided unless otherwise directed by a licensed health care professional. Beta-Blockers Potassium - Concomitant use of certain Beta-Blockers may increase potassium levels.Pepper (Piper Nigrum, Piper Longum ) - In single dose human study, piperine, a chemical found in black pepper and long pepper, was reported to increase blood levels of propranolol, which could increase the activity and risks of the drug's side effects.Antacids - One study showed a reduction in absorption of Sotalol(Betapace® ) when taken concomitantly with an aluminum oxide or magnesium hydroxide antacid. This interaction can be avoided by taking the medication two hours apart.Magnesium - Magnesium has been effectively used to treat heart arrythmias that have resulted from administration of Sotalol(Betapace® ). Calcium Channel Blockers Calcium - High level calcium supplementation may reverse the blood pressure-lowering actions of some calcium channel blocker drugs.Vitamin D - Vitamin D may interfere with the effectiveness of verapamil.St. John's Wort - A recent study showed that St. John's Wort decreased the bioavailability of R- and S-verapamil.Fruit Juices - Ingestion of grapefruit, grapefruit juice, and grapefruit products has been shown to increase the adverse effects of calcium channel blockers or similar drugs.Diuretics, Potassium-Sparing [Amiloride, Aldactone® (spironolactone), Dytac® (triamterene)] Magnesium - Magnesium tends to be preserved.HIV Antivirals St. John's Wort - St. John's Wort has been shown to speed up the elimination of indinavir which may result in resistance to the drug. St. John's Wort should not be taken concomitantly with HIV Antivirals.Sho-Saiko-To - This herbal medicine has been shown to enhance the antiviral activity of lamivudine.Carnitine - Depletion of Carnitine levels may be responsible for muscle and nerve damage in patients on Antiviral therapies. Canitine supplementation is recommended.Antioxidants - A small study showed a positive effect of antioxidant supplementation on hyperlactatemia (elevated levels of lactate in the systemic circulation) in patients on long-term Antiviral therapy.N-Aceylt Cysteine - Studies have shown supplementation a NAC during Antiviral therapy may reduce AZT toxicity.Vitamins E and C - Supplementation with Vitamin E has shown to improve the efficacy of AZT and supplementation with Vitamins E and C may reduce AZT-related cellular damage. NSAIDs (non-steroidal anti-inflammatory drugs) Copper - Copper may enhance the anti-inflammatory effects of NSAIDs. Indomethacin may cause sodium and water retention. Non-Narcotic Pain Relievers [Imitrex® (sumitriptan), Ultram® (tramadol)] St. John's Wort - Potential interactions may occur. Concomitant administration is not advised unless prescribed by a health care professional. Oral Contraceptives St. John's Wort - Concomitant use of St. John's Wort and oral contraceptives may reduce the effectiveness of the contraceptives and cause breakthrough bleeding.Serum Iron and Copper - Oral contraceptive use has been associated with an increase in iron and copper levels. Respiratory Corticosteroids Calcium - Calcium absorption was reduced following administration of oral beclomethasone (inhaler), a respiratory steroid similar to Flonase. Synthetic Thyroid Iron and Soy - Iron supplements and soy products taken at the same time as thyroid hormone replacement may interfere with absorption. Thyroid hormone absorption is increased when taken on an empty stomach. Thyroid hormones should be taken an hour before eating, at the same time every day.
For support of overall health in any individual, the appropriate comprehensive age- and gender-specific multiple formula, flax oil, and multiple antioxidant formula are recommended. However, for a specific potential deficiency, individuals may add single ingredient supplements to assure repletion. It is importantto consider the quality and bioavailability of vitamin and mineral supplements used for these purposes.
What is Saventaro? Saventaro is a special, patented form of Cat’s Claw (Uncaria tomentosa). Cat’s Claw is a vine deriving its name from hook-like thorns that resemble the claws of a cat. It grows in the tropical rainforests of South and Central America. Saventaro has been clinically studied to support healthy immune function.*
Can I take Saventaro daily? Saventaro is safe for long-term immune support for most individuals.
Anti-anxiety Miller LG. Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med . 1998;158:2200-2211. Abstract. Spinella M, Eaton LA. Hypomania induced by herbal and pha,aceutical psychotropic medicines following mild traumatic brain injury. Brain Inj . 2002 Apr; 16(4):359-67. (see reference SSRIs) Dannawi M. Possible serotonin syndrom after combination of buspirone and St. John's Wort J Psychopharmacol . 2002 Dec; 16(4):401. No abstract available. Lilja JJ, Kivisto KT, Backman JT, et al. Grapefruit juice substantially increases plasma concentrations of buspirone. Clin Pharmacol Ther . 1998 Dec; 64(6):655-60. Antibiotics Breen GA. Hypoprothrombinemia associated with cefmetazole Ann Pharmacother. 1997 Feb 31 (2) :180-4. Pelton R. LaValle JB. Drugs and Their Effects on Nutrition. In: The Nutritional Cost of Perscription Drugs. 2nd Edition Englewood, CO: Morton Publishing Company; 2004, 34-35. Horowitz S. Combining supplements and perscription drugs. Altern Complete Ther . 2000.pp.306. Brinker F. Vitamin/mineral/drug interactions. In:Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp.306 Foulds G, Hilligoss DM, Henery EB, Gerber N. The effects of an antacid or cimetidine on the serum concentrations of azithromycin. J Clin Pharmacol. 1991; 31:164-167. Abstract. Flockhart DA, Desta Z, Mahal SK. Selection of drugs to treat gastro-oesophageal reflux diease: the role of drug interactions. Clin Pharmakinet. 2000 Oct;39 (4):295-309. Anti-Diabetic Nestler JE, Beer NA, Jakubowicz DJ, et al. Effects of a reduction in circulating insulin by metformin on serum dehdtorpiandrosterone sulfate in nondiabetic men J Clin Endocrinol Metab . 1994 Mar;78(3):549-54. Crave JC, Fimbel S, Lejeune H, et al. Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women. J Clin Endocrinol Metab . 1995 Jul; 80(7):2057-62. AntiHistamines
Izzo AA. Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence. Int J Clin Pharmacol Ther . 2004 Mar; 42(3):139-48. Wang Z, Hamman MA, Huang SM, et al. Effect of St. John's Wort on the pharmacokinetics of fexofenadine. Clin Pharmacol Ther . 20002 Jun; 71(6):414-20. Dresser GK, Bailey DG. The effects of fruit juices on drug disposition: a new model for drug interactions. Eur J Clin Invest . 2003 Nov; 33 Suppl 2:10-6. Anti-Psychotics
Dursun SM, Oluboka OJ, Devarajan S, Kutcher SP. High-dose vitamin E plus Vitamin B6 treatment of risperidone-related neuroleptic malignant malignant syndrome. J Psychopharmacol . 1998; 12(2):220-1. Javitt DC, Silipo G, Cienfuegos A, Shelley AM, et al. Adjunctive high-dose glycine in the treatment of schizophrenia. Int J Neuropsychopharmacol . 2001 Dec; 4(4):385-91. Heresco-Levy U, Ermilov M, Lichtenberg P, Bar G, Javitt DC. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry . 2004 Jan 15;55(2):165-71. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry. 1999 Jan; 156(1):145-7. Anti-Seizure
Brinker F, Vitamin/mineral/drug interactions In: Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp. 305. Herbs Ibid. pp 27-42. Benzodiazepines
Miller LG. Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158:2200-2211. Abstract. Stevinson C, Huntley A, Ernst E. Systemic review of the safety of kava extract in the treatment of anxiety. Drug Saf 2002;25 (4) :251-61. Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A enzyme. JAMA. 2003 Sep 17; 290(11):1500-4. Beta-blockers
Gehr TW, Sica DA. Pharmacotherapy in congestive heart failure: Hyperkalemia in congestive heart failure. Congest Heart Fail. 2001 Mar-Apr; 7(2):97-100. Rosa RM, Silva P, Young JB, et al. Adrenergic modulation of extrarenal potassium disposal. N Engl J Med. 1980 Feb 21; 302(8):431-4. Bano G, Raina RK, Zutshi U, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol. 1991; 41(6):615-7. Laer S, Neumann J, Scholz H. Interaction between sotalol and an antacid preparation. Br J Clin Pharmacol. 1997 Mar; 43(3):269-72. Sasse M, Paul T, Bergmann P, et al. Sotalol associated torsades de pointes tachycardia in a 15-month-old child: successful therapy with magnesium aspartate. Pacing Clin Electrophysiol. 1998 May; 21(5):1164-6. Forlani S, Moscarelli M, Scafuri A, et al. Combination therapy for prevention of atrial fibrillation after coronary artery bypass surgery: a randomized trial of sotalol and magnesium. Card Electrophysiol Rev. 2003 Jun; 7(2):168-71. Calcium Channel Blockers
Haft JI, Habbab MA. Treatment of atrial arrhythmias. Effectiveness of verapamil when preceded by calcium infusion. Arch Intern Med. 1986;146:1085-89. Abstract. Weiss AT, Lewis BS, Halon DA, et al. The use of calcium with verapamil in the management of supraventricular tachyarrhythmias. Int J Cardiol. 1983;4:275-80. Abstract. Threlkeld DS, ed. Diuretics and Cardiovasculars, Calcium Channel Blocking Agents.In Facts and Comparisons Drug Information St. Louis, MO; Facts and Comparisons, Nov 1992, 150-150b. Tannergren C, Engman H, Knutson L, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr; 75(4):298-309. Bailey DG, Dresser GK, Kreeft JH, et al. Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. Clin Pharmacol Ther. 2000 Nov;68(5):468-77. Baily DG, Arnold MD, Strong HA, Munoz C, Spence JD, et al. Effect of grapefruit juice and maringin on nisoldipine pharmacokinetics. Cli Pharmacol Ther.1993;54:589-94. Abstract Diuretics, Potassium-Sparing
Devane J, Ryan MP. The effects of amiloride and triameterene on urinary magnesium excretion in conscious saline-loaded rats. Br J Pharmacol 1981;72:285-89 HIV Antivirals
Henderson L, Yue QY, Bergquist C, et al. St John's wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol. 2002 Oct;54(4):349-56. Review. James JS. St. John's wort warning: do not combine with protease inhibitors, NNRTIs. AIDS Treat News. 2000 Feb 18 ;( No 337):3-5. Piras G, Makino M, Baba M. Sho-saiko-to, a traditional Kampo medicine, enhances the anti-HIV-1 activity of lamivudine (3TC) in vitro. Microbiol Immunol. 1997; 41(10):835-9. Moretti S, Famularo G, Marcellini S, et al. L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1-infected subjects treated with zidovudine and didanosine. Antioxid Redox Signal. 2002 Jun;4(3):391-403. Lopez O, Bonnefont-Rousselot D, Edeas M, et al. Could antioxidant supplementation reduce antiretroviral therapy-induced chronic stable hyperlactatemia? Biomed Pharmacother. 2003 May-Jun; 57(3-4):113-6. Patrick L. Nutrients and HIV: part three - N-acetylcysteine, alpha-lipoic acid, L-glutamine, and L-carnitine. Altern Med Rev. 2000 Aug;5(4):290-305. Review. Gogu SR, Agrawal KC. The protective role of zinc and N-acetylcysteine in modulating zidovudine induced hematopoietic toxicity. Life Sci. 1996; 59(16):1323-9. Gogu SR, Beckman BS, Rangan SR, Agrawal KC. Increased therapeutic efficacy of zidovudine in combination with vitamin E. Biochem Biophys Res Commun. 1989 Nov 30;165(1):401-7 Wang Y, Watson RR. Is vitamin E supplementation a useful agent in AIDS therapy? Prog Food Nutr Sci. 1993 Oct-Dec;17(4):351-75. Review. de la Asuncion JG, del Olmo ML, Sastre J, et al. AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins. J Clin Invest. 1998 Jul 1; 102(1):4-9. NSAIDs (non-steroidal anti-inflammatory drugs)
Sorenson JRJ. Copper chelates as possible active forms of the antiartritic agents. J Medicinal Chem 1976;19:135-48. Somova L, Zaharieva S, Ivanova M. Humoral factors involved in the regulation of sodium-fluid balance in normal man. II. Effects of indomethacin on sodium concentration, renal prostaglandins, vasopressin and renin-angiotensin-aldosterone system. Acta Physiol Pharmacol Bulg 1984;10:29-33. Non-Narcotic Pain Relievers
Brinker F, Vitamin/mineral/drug interactions In: Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp. 183 Oral Contraceptives
Newhouse IJ, Clement DB, Lai C. Effects of iron supplementation and discontinuation on serum copper, zinc, calcium, and magnesium levels in women. Med Sci Sports Exerc. 1993 May; 25(5):562-71. Milman N, Rosdahl N, Lyhne N, et al. Iron status in Danish women aged 35-65 years. Relation to menstruation and method of contraception. Acta Obstet Gynecol Scand. 1993 Nov; 72(8):601-5. Frassinelli-Gunderson EP, Margen S, Brown JR. Iron stores in users of oral contraceptive agents. Am J Clin Nutr. 1985 Apr; 41(4):703-12. Respiratory Corticosteroids
Smith BJ, Phillips PJ, Pannall PR, et al. Effect of orally administered beclomethasone dipropionate on calcium absorption from the gut innormal subjects. Thorax. 1993 Sep; 48(9):890-3. Synthetic Thyroid
Beard JL, Borel M, Peterson FJ. Changes in iron status during weight loss with very low-energy diets. Am J Clin Nutr. 1997;66:104-110. Abstract. Beard JL, Borel MJ, Derr J. Impaired thermoregulation and thyroid function in iron deficiency anemia. Am J Clin Nutr 1990;52:813-819. Abstract. Campbell NR, Hasinoff BB. Iron supplements: A comon cause of drug interactions. Brit J Clin Pharmacol. 1991;31:251-255. Abstract. Jabbar MA, Larrea J, Shaw RA. Abnormal thyroid function tests in infants with congenital hypothyroidism: The influence of soy-based formulas. J Am Coll Nutr 1997;16:280-282. Abstract. Threlkeld DS, ed. Hormones, Thyroid Hormones. In: Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons; 1991:131-133c. 1. Reinhard KH. Uncaria tomentosa (Willd.) D.C.: cat's claw, uña de gato, or savéntaro. J Altern Comp Med. 1999;5:143-151.
Our Price: $10.73 Retail Price: $16.50 You Save: $5.77 each, a 35% Savings!
