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PepZin GI
by Doctors Best
120 Vegetarian Capsules
Promotes Healthy Gastric Function*
Our Price: $15.88
Retail Price: $29.99
You Save: $14.11 each, a 47% Savings! | 
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PepZin GI is an exclusive, patented complex of zinc and L-carnosine that was first developed in Japan and has been in use since 1994. This special chelated form of the mineral zinc has a unique ability to exert its effects directly on the cells of the stomach lining. When zinc is complexed to L-carnosine, it dissociates in the stomach at a slower rate. This prolonged existence allows it to maintain its gastric healing effect over a longer period of time. The proprietary chelation process along with excellent scientific research make PepZin GI your best choice for supporting gastric health.* PepZin GI Helps Relieve Occasional Discomfort
In a randomized, multi-center, placebo-controlled double blind study, 299 patients suffering with symptoms of gastric discomfort were randomly allocated to receive either a zinc-L-carnosine complex or a placebo, or a control drug or its placebo for 8 weeks. Improvement ratings for a range of symptoms were taken at various points during the trial and compared with before treatment data. Of the 258 people who completed the trial, 136 were in the zinc-L-carnosine group. Of the group, 92% of the participants were rated as “moderately improved” or better on an improvement scale across the category of symptoms including heartburn, tenderness, epigastric pain, diarrhea and constipation after 8 weeks.* In another study, 28 patients with gastric discomfort were given a zinc-L-carnosine compound and monitored for 8 weeks. Improvement was rated on a scale of subjective and objective symptoms. After 4 weeks, the rate of those cases that were considered to be “significantly improved” was 68.4%. After eight weeks, the “significantly improved” number was 68.8%. Over 60% of these patients remained in the “significantly improved” category well after discontinuation of the treatment, suggesting a lasting effect of the zinc-L-carnosine compound beyond the time it is taken.* Maintains a Healthy GI Environment
The mineral zinc in PepZin GI is a critical component to a number of physiological processes in our bodies. Some of these functions include growth and metabolism of cells, healing of wounds, and maintenance of carbohydrate and lipid metabolism.* PepZin GI may also be able to favorably maintain the bacterial balance of the stomach and GI tract. Studies suggest that the zinc-L-carnosine compound may have effects on certain strains of harmful bacteria, and therefore may be able to help maintain a GI environment that is favorable to health. By supporting the bacterial balance in the stomach, PepZin GI can help maintain a healthy mucosal lining.* Supports the Health of Gastric Cells
PepZin GI has been studied for its ability to prevent free radical damage to gastric cells. In one such study, rat gastric cells were exposed to ethanol and hydrogen peroxide, two substances known to cause free radical damage to living cells. Cells were bathed in hydrogen peroxide, ethanol, zinc-L-carnosine, or a combination of zinc-L-carnosine with either ethanol or hydrogen peroxide. While the cells bathed in ethanol and hydrogen peroxide solutions all exhibited signs of damage due to free radical production, the cells that were bathed in zinc-L-carnosine were largely protected from the effects of free radical damage. The authors concluded that the zinc compound directly protected gastric mucosal cells from oxidant stress and alcohol induced damage.* Additional research further confirms the gastro-protective effects of PepZin GI. In another rat study, stomach lesions were induced by administration of the chemical monochloramine, a known pro-oxidant (producer of free radicals). One of the groups of rats was fed the zinc-Lcarnosine compound prior to being exposed to monochloramine. The researchers found that the size of the lesions in the group pre-treated with zinc-L-carnosine was significantly less than the lesions in the control group. The authors concluded that the zinc compound exerted a beneficial protective effect against monochloramine-induced stomach lesions.* The zinc-L-carnosine in PepZin GI has also been shown to slow the development of aspirin-induced stomach damage in rats. The researchers detected measurably lower levels of TNF-alpha in rats given zinc-L-carnosine as compared to the control rats. TNF-alpha is an inflammatory cytokine that is known to be released in response to gastric damage. These results may suggest a role for PepZin GI in protecting gastric cells by occasionally reducing the levels of certain cytokines in minor inflammation of the stomach.*
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Supplement FactsServing Size: One (1) Capsule
Servings Per Container: 120 | | | | Amount
Per Serving | Daily
Value | Zinc
(From PepZin GI) | 8 mg | 53% | PepZin GI
(Zinc-L-Carnosine Complex) | 37.5 mg | ** | L-Carnosine
(From PepZin Gi) | 29.5 mg | ** | | | PePZinGI is a registered trademark of Lonza Inc. Protected By U.S Patent 4981846. |
** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet. |
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| Calcium Carbonate, Magnesium Stearate (Vegetable Source), Modified Cellulose (Vegetarian Capsule), Silicon Dioxide |
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| As a dietary supplement, one (1) capsule two (2) times daily during or after meals, or more as directed by your healthcare practitioner. |
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| If pregnant or nursing, consult your healthcare provider before taking this, or any, supplement. ... Keep out of reach of children. ... Store in a cool, dry place. |
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| Doctors Best products do not contain milk, egg, wheat, yeast, corn, sugar, sweeteners, starch, salt, preservatives, waxes, coating or colors. Doctor's Best products are also GLUTEN FREE. |
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| Cell Vitality, Cellular Oxidation, Constipation, Cramps, Diarrhea, Digestive Balance, Digestive Comfort, Digestive Inconsistancy, Free Radicals, Gastroesophageal reflux, Gastrointestinal Motility, Gastrointestinal Vitality, GERD, Heartburn |
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| Cell, Cellular Function, Digestive System, Esophagus, GI Tract, Intestinal Lining, Intestinal Mucous Membrane, Intestine, Stomach |
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| Impetuous |
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We firmly believe that the integration of scientific research and traditional wisdom is how nutritional and herbal supplements will reach their exciting potential. Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Careful research and precise formula development keeps us at the leading edge of quality, effectiveness, and innovation. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Countless hours have been spent analyzing scientific literature to provide sound alternatives to the proliferation of questionable supplements in the marketplace. Each Doctor's Best product is accompanied by an annotated "Fact Sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with the FDA in accordance with DSHEA regulations. Traditional wisdom, up-to-date research, product quality you can trust: everything you need to develop smart strategies for achieving optimal health and well-being. We think you’ll agree that this combination of products and services is second to none. |
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Q. What are your capsules made of?
A. Doctor's Best capsules are typical gelatin capsules, with the exception of select products now available in veggie cap form. They are made of gelatin from cattle, like the familiar "Knox gelatin" sold in grocery stores.
The gelatin used to make Doctor's Best's capsules is manufactured in accordance with strict guidelines that ensure it is BSE-free. The FDA and the supplement industry approved these guidelines. The gelatin is made only from cattle living in non-BSE countries. All Doctor's Best capsules are in full compliance with the FDA's September 1997 industry guide, The Sourcing and Processing of Gelatin to Reduce the Potential Risk Posed by Bovine Spongiform Encephalopathy in FDA-Regulated Products for Human Use.
Q. How long does it take for a capsule to dissolve?
A. Approximately 30-45 minutes. For 2-piece gelatin capsule, the USP standard for maximum dissolution time is 45 minutes.
Q. How long does it take for a tablet to dissolve?
A. FDA Rules & Regulations require tablets to dissolve in 45 minutes or less. However, Doctor's Best sets its standards higher. They require that their tablets dissolve in 30 minutes or less. Every lot of products in tablet form is tested to verify that it dissolves in under 30 minutes.
Q. Can I find out how fast a capsule or tablet dissolves by dropping it in a glass of water or vinegar at home?
A. Testing dissolution times at home using vinegar is not an accurate way to learn what happens to capsules and tablets in your stomach. Because stomach acid is much stronger than vinegar, capsules and tablets dissolve much faster in the stomach than in a glass of water or vinegar. Also, the stomach continually "agitates" its contents, much like a washing machine does.
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Q. Who determines what the daily dosage should be? And how is this done?
A. A panel of scientists at The Natural Academy of Sciences performs extensive research, ongoing clinical studies and scientific testing in order to determine the RDI (Recommended Daily Intake).
Q. I see that Silicon Dioxide has been used as an excipient in some of your products. Should I be concerned?
A. Silicon Dioxide is a GRAS (Generally Recognized As Safe) food additive. Numerous studies have found the following:
The oral toxicity for humans would be greater than 350 grams in one dose based on allometric comparisons between the mice studied and humans.
A single dose of 2,500mg of amorphous polymeric silicon dioxide to human volunteers did not significantly raise the SiO2 excretion in the urine. This suggests poor absorption of silicon dioxide (Langendorf 1966).
Less than one one-hundredth (1/100th) of the dose was found in urine, suggesting extremely poor absorption (Langendorf 1966).
This would suggest that there is no scientific reason to eliminate silicon dioxide as an excipient at the very low levels found in dietary supplements.
Q. Why is silicon dioxide used as an excipient in Doctor’s Best products? Why are excipients used at all?
A. Silicon Dioxide is used as a flow agent to enable "sticky" substances to flow through the encapsulation equipment. If silicon dioxide were not used, other flow agents would have to be used which would actually increase the number of excipients found in a given product. Ideally, the fewer excipients used, the better.
Q. Is there a limit to how many vitamins can be taken safely in one day?
A. Our bodies need vitamins and minerals, and if taken in large amounts, vitamins and minerals can adversely affect health. Large amounts of anything can be toxic. Our best advice is to work with a nutritionally aware doctor and follow label directions. |
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1. Kuwayama H, et al. Polaprezinc. Nippon Rinsho 2002 Feb; 60 Suppl 2:717-720.
2.Matsukura T,Tanaka H. Applicability of zinc complex of l-carnosine for medical use. Biochemistry (Moscow) 2000;65(7):817-823.
3.Miyoshi A, et al. Clinical evaluation of Z-103 on gastric ulcer - a multicenter double-blind comparative study with cetraxate hydrochloride. Jpn PharmTher 1992;20(1):199-223.
4.Misawa T, et al. Clinical study of Z-103 - clinical effects on gastric ulcer and influence on endocrine function. Jpn PharmTher 1992; 20(1):245-254.
5. Hiraishi H, et al. Polaprezinc protects gastric mucosal cells from noxious agents through antioxidant properties in vitro. Aliment Pharmacl Ther 1999;13:261-269.
6. Kato S, Nishiwaki H, et al. Mucosal ulcerogenic action of monochloramine in rat stomachs: effects of polaprezinc and sucralfate. Dig Dis Sci 1997;42(10):2156-2163.
7.Naito Y, et al. Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury. Dig Dis Sci 2001;46(4):845-851. |
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Our Price: $15.88
Retail Price: $29.99
You Save: $14.11 each, a 47% Savings! |
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