Supplement Facts

Liposomes consist of Essential Phospholipids (EPL) which are natural substances that form the outer membrane of every living cell in humans and animals. The following are a description of the additional vascular benefits of LipoFlow™ EPL products.

Essential Phospholipds (EPL) have shown the following cardiovascular benefits in over 100 clinical trials in Europe and in the US for doses as low as 1 gm of EPL per day. All LipoFlow™ products approach intravenous level assimilation through micro encapsulation in an EPL oral delivery system.

• Clinical Studies (controlled against diet, double blinded placebo controlled or open) show substantial improvements in lowering Mean Total Serum Cholesterol (12% to 25%).
• Significant decrease in LDL (so called "bad cholesterol") in double blind clinical studies with LDL with reduction ranging to 34%.
• Significant increase in HDL (so called "good cholesterol") was observed by 5 different clinicl researchers varying from 50% to 100% increase after 1 to 3 months treatment.
• Significant reduction in serum triglycerides.
• Very substantial lowering of cardiovasvular risk ratio 5.6 reduction to 3.7 in a double blind trial (Kirsten, R.) 4.3 reduction to 2.8 in a 4-week open study. (Goto, Y., Nakamura H.)
• Increased peripheral and brain circulation.
• Decreased reactive platelet aggregation in patients with agina pectories (60% lower).
• Significant decrease in anginal (chest pain stage III and IV) attacks or in some patients a total elimination of aginal attacks (chest pain).
• Exercise tolerance with angina prone patients increased as much as 200% before anginal pain is observed or nitro glycerine is required.

 Background

Essential phospholipids (EPL) are natural components of human and animal cells forming the outer membrane that contain them. Without EPL life as we know it is not possible. A continuous supply of EPL, or its constituents, are absolutely necessary for human health and well being.  A natural source for EPL is soy lecithin from which it is extracted through a rather expensive process. EPL is particularly rich in polyunsaturated fatty acids with linoleic and linolenic fatty acids accounting for 70% of EPL's fatty acid content. These are termed essential fatty acids because they must be taken in with food since the human body cannot synthesize them. The effects on the human body taking EPL as a nutritional supplement and as a transport mechanism for other supplements are truly amazing.

Benefits of Essential Phospholipids:

The first and foremost benefit of EPL is the positive effect on your heart. The risk of developing heart disease for those age 40 and older in the United States is one in two for men, and one in three for women. Also, heart disease is the leading cause of death for adults worldwide. Public clinical studies performed by Rhone Poulenc Rorer, a large pharmaceutical company in Europe, for their EPL product Lipostabil™ shows that EPL prevents the development of hypercholesterolaemia and hypertriglyceridaemia in doses as little as 300 mg of EPL per day. In larger doses EPL normalizes LDL cholesterol, total cholesterol, as well as triglycerides in serum. EPL also reverses pathological tissue accumulation from vascular walls. Thus, EPL is an all-natural replacement for Statin Drugs but without side effects.  Lipoflow has developed several EPL products which are available as a therapeutic liquid gel (containing 1000 mg EPL per teaspoon). The intake of EPL as a nutritional supplement is a convenient way to supply your body with the essential fatty acids it needs and to take advantage of the above mentioned benefits. The second benefit of EPL combines the first effect described above with the ability by phospholipids to provide an effective transport mechanism through biological membranes and skin. Under certain physical conditions phospholipids can be made to form microscopic cellular structures whose walls are very similar in construction to the actual cell membrane as shown in the figure to the right.

The size of these spheres is very small, in the order of nanometers. As illustrated, the spheres are hollow inside and  contain the liquid material in which they were formed (inclusion). Because of the small size of the phospholipid molecule and nanospheres, they can pass through biological membranes and act as a carrier for enclosed substances. Lipoflow uses a natural blend of highly refined Phospholipids from soy lecithin which is used to form closely packed liposome gels. Each cellular structure (vesicle) contains the desired pharmaceutical solution for delivery through the respective membrane. The first figure below depicts an electron microscope image of such a gel. As the image shows, there is very little space left between the vesicles, which contains the same material that is inside.  Once this gel has been formed it is stable and can be diluted and added to oral products for delivery through the respective membranes. The second figure depicts an electron microscopic photo of a diluted liposome preparation. The inter-cellular space now can consist of a different liquid than contained in the vesicles. The stability of these products is about one year.

Recent clinical tests

Recent clinical tests have verified that EPL encapsulated substances pass through biological membranes directly into the blood stream, effectively bridging the intestinal barrier, for systemic heavy metal detoxification. This novel new oral form of disodium EDTA was tested clinically with sixteen patients.  A baseline 24 hour urine was initially collected followed by provocation of two fluid ounces of Lipoflow oral EDTA in fruit juice, containing one gram of disodium EDTA nanoencapsulated in essential phospholipids. Two successive twenty-four hour urine collections followed the initial provocation of Lipoflow oral EDTA. Excellent maximum increases in urine excretion over baseline control results were obtained: Aluminum >>100% (960 ug/24 hrs), Antimony 50%, Arsenic 1558%, Bismuth 6801%, Cadmium 233%, Lead 4333%, Mercury 312%, Nickel 1988%, Platinum >100% (0.05 ug/24 hrs), Thallium 300%, Thorium >100% (0.05 ug/24 hrs), Tin 1980%, Tungsten 150%, and Uranium >100% (0.09 ug/24 hrs).

Examples of EPL applications using nanospheres:

1. As a side-effect-free alternative to Statin Drugs.

2. Detoxification and vascular disorders like atherosclerosis:

Ethylenediaminetetraacetic Acid (EDTA) is extensively used to remove toxic and heavy metals from the body and also to obtain cardiovascular benefits. EDTA is usually administered intravenously and takes 2-3 hours per administration. One series of treatment consists of 10-30 administrations with 1-3 g of EDTA each.  It is well known that oral administration of EDTA is very inefficient in that only about 5% of EDTA passes into the blood stream. In addition, larger than 500 mg doses, taken orally, result in instant diarrhea. When EDTA is encapsulated in EPL nanospheres, however, even doses as high as 2 g and more per oral administration do not produce diarrhea and over 90% of the EDTA pass into the blood stream. In addition to the cardiovascular benefits, the large dose of EPL alone (10 g of EPL per administration) normalize LDL cholesterol, total cholesterol, as well as triglycerides in serum. EPL also reverses pathological tissue accumulation from vascular walls. Lipoflow private labels oral EDTA Liposome Products to select Distributors in the U.S.

3. Mega Vitamin C Therapy and vascular disorders:

Ascorbic acid (vitamin C) is another beneficial substance that is not well tolerated when administered orally in high doses. Like EDTA, vitamin C causes diarrhea in doses larger than 2-3 grams. High doses of ascorbic acid are also administered intravenously for this reason.  When vitamin C is encapsulated in EPL nanospheres, however, even doses as high as 10 g and more per oral administration do not produce diarrhea and over 90% of the vitamin C passes into the blood stream. As is well known, large doses of vitamin C are administered for various reasons like Colds and Flu, Hepatitis C, Herpes, HIV, Mono, MS, ALS, CFS/FM, Cancer Maintenance Programs, Detoxification, and Cardiovascular enhancement. Additionally, large dose of EPL (10 g of EPL per administration) normalize LDL cholesterol, total cholesterol, as well as triglycerides in serum. EPL also reverses pathological tissue accumulation from vascular walls. Lipoflow private labels oral MEGA Vitamin C Liposome Products to select Distributors in the U.S.

4. Micro Encapsulated water/alcohol soluble drugs for oral and topical Application for Physicians.

Any water soluble nutrient or drug can be encapsulated by the Lipoflow process in EPL nanospheres and administered to patients for systemic absorption either by oral or topical route.