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Douglas Labs

Niacinate
by Douglas Labs
90 Tablets

Supports Cardiovascular And Cholesterol Health*

Our Price: $22.40

Niacinate tablets, provided by Douglas Laboratories, contain 600 mg of inositol hexaniacinate which provides 540 mg of niacin. This ester of niacin and inositol eliminates the uncomfortable skin-flushing side effects often observed with high-dose crystalline niacin.

FUNCTIONS
Niacin (vitamin B-3) occurs in the body as two metabolically active coenzymes, NAD (nicotinamide adenine dinucleotide) and NADP (NAD phosphate). The niacin coenzymes NAD and NADP have pervasive roles in energy-related and biosynthetic metabolic processes. * At least 200 enzymes depend on these niacin cofactors. The NAD-dependent enzymes are involved in mostly catabolic, oxidative reactions that release energy from carbohydrate, fat, and protein, whereas the NADP-dependent enzymes more commonly function in biosynthesis of such compounds as fatty acids and steroid hormones. Independent of its functions as NAD or NADP, niacin is also involved in the regulation of normal blood lipoprotein and cholesterol levels, and the maintenance of normal vascular tone.*

Dietary niacin is generally well absorbed and taken up by the liver. Any excess niacin is metabolized by the liver and excreted by the kidneys.*

Because the liver has a limited capacity for metabolizing niacin, high doses of regular, crystalline niacin are often not well tolerated, causing vasodilatory side effects known as skin-flushing and itching. For maximum benefit and fewer side effects, Niacinate releases its niacin over a longer time frame than crystalline niacin.

INDICATIONS
Niacinate tablets may be a useful nutritional adjunct for individuals who wish to increase their intake of niacin without the uncomfortable side effects of skin flushing.

NOTE: Special Order Product Product - Special Shipping Required
This is a Special Order Product. We stock this in low quantities, due to low-to-moderate sales volume. If the product is on hand, we will ship immediately. If we are out of stock at the time of your order, we will order directly from the manufacturer, on your behalf. This could add an additional 2 to 5 business days to your delivery time.

Supplement Facts Serving Size: One (1) Tablet Servings Per Container: 90

	Amount Per Serving	Daily Value
Niacin (As Inositol Hexaniacinate)	540 mg	2,700%

Inositol (From Inositol Hexaniacinate)	54 mg	**

** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet.

Other Ingredients

Cellulose, Dicalcium Phosphate, Silica, Stearates (Vegetable Source), Stearic Acid

Suggested Use

As a dietary supplement for adults, take one (1) tablet up to three (3) times daily with meals, or more as directed by physician.

Warnings

Keep out of the reach of children ... Store in a cool, dry place ... Do not use if outer seal is missing.

Allergen Info

This product contains NO yeast, no wheat gluten, no soy protein, no milk/dairy, no corn, no sodium, no sugar, no starch, no preservatives, and no artificial coloring or flavoring.

Applicable Functions

Cardiovascular Health, Cholesterol Health

Related Structure Groups

Cardiovascular, Heart, Liver

REFERENCES

Aylward M. Hexopal in Raynaud’s disease. J Int Med Res 1979;7:484-491.

Canner PL et al. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol 1986;8:1245-1255.

Colletti RB et al. Niacin treatment of hypercholesterolemia in children. Pediatrics 1993;92:78-82.

Holti G. An experimentally controlled evaluation of the effect of inositol nicotinate upon the digital blood flow in patients with Raynaud’s phenomenon. J Int Med Res 1979;7:473-483.

O’Hara J et al. The therapeutic efficacy of inositol nicotinate (Hexopal) in intermittent claudication: a controlled trial. Brit J Clin Pract 1988;42:377-383.

Probstfield JL. Nicotinic acid as a lipoprotein-altering agent: therapy directed by the primary physician. Arch Int Med 1994;154:1557-1559.

Sunderland GT et al. A double blind randomized placebo controlled trial of hexopal in primary Raynaud’s disease. Clin Rheumatol 1988;7:46-49.

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