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Douglas Labs

N-Acetyl-L-Cysteine 750 Mg
by Douglas Labs
90 Capsules

Supports Production Of Antioxidant Elements*

Our Price: $32.80

N-Acetylcysteine (NAC) capsules, provided by Douglas Laboratories, contain 750 mg pure N-acetyl-L-cysteine. NAC is a biologically active precursor for the amino acid cysteine which, in turn, is a precursor for glutathione, a tripeptide with antioxidant properties.

FUNCTIONS
Body cells and tissues are threatened continuously by damaging, toxic free radicals and reactive oxygen species (e.g., peroxides) which are produced during normal oxygen metabolism, by other chemical reactions, and by toxic agents in the environment. Free radicals, once formed, are capable of disrupting metabolic activity and cell structure. When this occurs, additional free radicals are produced which, in turn, can result in more extensive damage to cells and tissues. The uncontrolled production of free radicals is thought to be a major contributing factor to many degenerative diseases.*

NAC is a precursor for the sulfur amino acid cysteine, which is used by the body to synthesize glutathione. Glutathione is a naturally occurring tripeptide which is a major component of two anti-free radical enzymes, glutathione peroxidase and glutathione reductase. As such, glutathione offers one mechanism for scavenging toxic free radicals and inhibiting peroxidation thereby slowing down free-radical catalyzed chain reactions. Glutathione per se is well absorbed in the intestine, and enters the blood and other extracellular compartments where it exerts much of its beneficial antioxidant effects. However, it can not effectively enter the cell.

In contrast to glutathione, NAC is efficiently transported into the cell where it is readily converted to cysteine for glutathione synthesis. Thus, supplementation with NAC can raise intracellular glutathione levels.*

Providing supplemental cysteine to elevate intracellular glutathione levels is generally not advised due to cysteine’s inherent toxicity. NAC is virtually non-toxic and well absorbed, which is why supplementation with NAC is recognized as a safe, highly effective method of increasing intracellular glutathione stores.*

Aside from providing cysteine as a glutathione precursor, NAC also appears to have antioxidant properties, and as such is a valuable sulfur donor for various metabolic needs.

NOTE: Special Order Product Product - Special Shipping Required
This is a Special Order Product. We stock this in low quantities, due to low-to-moderate sales volume. If the product is on hand, we will ship immediately. If we are out of stock at the time of your order, we will order directly from the manufacturer, on your behalf. This could add an additional 2 to 5 business days to your delivery time.

Supplement Facts Serving Size: One (1) Capsule Servings Per Container: 90

Amount Per Serving	Daily Value
N-Acetyl Cysteine	750 mg	**

** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet.

Other Ingredients

Gelatin Capsule, Stearates (Vegetable Source)

Suggested Use

As a dietary supplement, one (1) capsule daily at the start of a meal, or more as directed by your healthcare practitioner. ... It is recommended that NAC be taken in conjunction with vitamins and minerals. ... To effectively increase both extracellular and intracellular glutathione levels, this product and glutathione may be taken concurrently.

Warnings

Keep out of the reach of children ... Store in a cool, dry place ... Do not use if outer seal is missing.

Allergen Info

This product contains NO yeast, no wheat gluten, no soy protein, no milk/dairy, no corn, no sodium, no sugar, no starch, no preservatives, and no artificial coloring or flavoring.

Applicable Functions

Amino acid deficiency, Free Radicals, Liver Toxicity, Liver Wellness - deep

Related Structure Groups

Amino Acids, Cell, Cellular Function, Liver

REFERENCES

Aruoma, OI, Halliwell, B, Hoey, BM, Butler, J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989;6:593-7.

Ben-Ari, Z, Vaknin, H, Tur-Kaspa, R. N-acetylcysteine in acute hepatic failure (non-paracetamol-induced). Hepatogastroenterology 2000;47:786-9.

Cuzzocrea, S, Mazzon, E, Costantino, G, Serraino, I, Dugo, L, Calabro, G, Cucinotta, G, De Sarro, A, Caputi, AP. Beneficial effects of n-acetylcysteine on ischaemic brain injury. Br J Pharmacol 2000;130:1219-26.

Dobrzynska, I, Skrzydlewska, E, Kasacka, I, Figaszewski, Z. Protective effect of N-acetylcysteine on rat liver cell membrane during methanol intoxication. J Pharm Pharmacol 2000;52:547-52.

Grandjean, EM, Berthet, P, Ruffmann, R, Leuenberger, P. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebocontrolled clinical trials. Clin Ther 2000;22:209-21.

Holdiness, MR. Clinical pharmacokinetics of N-acetylcysteine. Clin Pharmacokinet 1991;20:123-34.

Martinez Banaclocha, M. N-acetylcysteine elicited increase in complex I activity in synaptic mitochondria from aged mice: implications for treatment of Parkinson's disease. Brain Res 2000;859:173-5.

Ortolani, O, Conti, A, De Gaudio, AR, Moraldi, E, Cantini, Q, Novelli, G. The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock. Am J Respir Crit Care Med 2000;161:1907-11.

Rubio, ML, Sanchez-Cifuentes, MV, Ortega, M, Peces-Barba, G, Escolar, JD, Verbanck, S, Paiva, M, Gonzalez Mangado, N. Nacetylcysteine prevents cigarette smoke induced small airways alterations in rats. Eur Respir J 2000;15:505-11.

Woo, OF, Mueller, PD, Olson, KR, Anderson, IB, Kim, SY. Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose. Ann Emerg Med 2000;35:363-8.

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