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Liquid Glucosamine & Chondroitin
by NOW Foods - Joint And Immune Enhancers
16 oz. Liquid
Superior Joint Support; Easily Absorobed Liquid Form*
Our Price: $10.93
Retail Price: $18.88
You Save: $7.95 each, a 42% Savings! | 
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Liquid Glucosamine & Chondroitin with MSM combines three of the most effective nutrients available today for supporting good joint health in an easily absorbed liquid form. Glucosamine and Chondroitin are naturally occurring structural components that are used by the body to support healthy joint function. MSM, Manganese and Vitamin C complement Glucosamine and Chondroitin and work synergistically with them to provide optimal nutritional support.*
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NOTE: Oversized Product - slightly higher shipping cost Product - Special Shipping Required
This product is heavier and/or bulkier than our standard products. As a result, our customary $5.40 standard shipping charge and our 'Free Shipping Over $100' offer does NOT apply to this product. Your actual shipping cost for this item MAY be slightly higher. You can determine the exact charge for your geographic location directly in our shopping cart. |
Supplement Facts
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| One (1) Tablespoon (15 mL) Supplies: |
Amount Per Serving |
| Calories | 15 |
Vitamin C
(ascorbic acid) | 125 mg |
Manganese
(manganese amino acid chelate) | 4 mg |
| Sodium | 60 mg |
| Potassium | 5 mg |
| Glucosamine HCl | 750 mg |
Chondroitin
(Sodium Sulfate)
(from Bovine Carilage) | 600 mg |
| MSM (Methylsulfonylmethane) | 150 mg |
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| Xanthan Gum, Vegetable Glycerin, Sodium Benzoate, Potassium Sorbate, Natural Flavor, Natural Beta-Carotene, Malic Acid, Fructose, Deionized Water, Citric Acid, Contains SHELLFISH derivative. Contains no starch, yeast, wheat, gluten, soy, milk, egg or artificial colors or flavors. |
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| As a dietary supplement, one (1) tablespoon, twice (2x) daily, or as directed by a healthcare practitioner. |
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| Persons with a known allergy to shellfish should not use this product. |
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| Connective Tissue Support, Joint Support, Liquid Mineral |
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| Dislocated Joint, Joint Pain, Neck Pain |
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| Connective Tissue, Joints, Muscles |
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| Absorbed, Discomfort, Pain |
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What is glucosamine? Glucosamine is composed of glucose and glutamine (an amino acid). It is utilized by chondrocytes to form glycosaminoglycans (GSG’s) and proteoglycans. Both of these constituents attract and bind water into cartilage, increasing resiliency. How is glucosamine manufactured? Glucosamine is supplied mostly by China. The shells of shrimp and crabs have their proteins and minerals removed producing Chitin or poly N-acetylglucosamine. Manufacturers use acid with a depolymerizing and deacetylating process to produce glucosamine hydrochloride or glucosamine sulfate. What is the source of your Chondroitin, and is it BSE free? NOW® Chondroitin is derived from bovine tracheal tissue. The cattle are raised in China. As with all of our raw materials, we screen Chondroitin very carefully for the presence of any undesirable microbes, and is BSE Free. |
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| By Joseph Zhou, Ph.D., Director of Lab Methods, NOW Foods Quite a few of NOW customers have sent their feedback to us, commenting that they have tried many other brands of glucosamine, chondroitin and MSM products and did not get satisfactory results. But they are happy with NOW products because, in their words, these products work! Glucosamine, chondroitin and MSM are combination components that promote joint health. Glucosamine is a basic building block of the cartilage that cushions the joints, and chondroitin is a more complex constituent substance of that cartilage, while MSM provides plentiful amounts of the mineral sulfur to the cartilage. Studies have shown that glucosamine, chondroitin and MSM can each effectively relieve occasional pain and stiffness without the side effects of conventional analgesics. As pharmaceutical products may contribute to a higher risk of heart disease, a significant number of consumers want to try natural joint support nutrients first. The secret of how NOW’s joint support products show high efficacy is their quality. NOW’s scientists have developed many excellent analytical methods to support product development and maintain quality control. These analytical methods are backed by rigorous science. Most of them consist of the innovative use of simple procedures, thus requiring less time and lower costs to run than standard tests. NOW’s analytical methods are recognized by AOAC International, a 120-year-old not-for-profit scientific association committed to worldwide confidence in analytical results. For example, AOAC’s Expert Review Panel (ERP) on glucosamine and chondroitin respectively selected NOW’s glucosamine and chondroitin methods as the best methods for further laboratory validation. After AOAC rigorous single laboratory validation (SLV) and collaborative study, the glucosamine method is now an AOAC Official MethodSM, designated as AOAC method 2005.01, and the method is now widely used throughout the industry. NOW’s chondroitin method is currently in the process of AOAC validation and is expected to become another AOAC official method. We are now performing the single laboratory validation of NOW’s MSM method for AOAC. The AOAC Official Method Program is the result of a contract between the FDA’s Center for Food Safety and Applied Nutrition and the NIH’s Office of Dietary Supplements with AOAC International. The purpose of the contract is to provide government agencies and the dietary supplements industry with AOAC Official Methods that are applicable to commercially available dietary supplements and raw materials. Accurate and precise analytical methods guarantee and promote good quality products. For example, NOW’s analytical method for chondroitin sulfates is an enzymatic HPLC method. Because both the specific enzyme and modern HPLC separation techniques are used, this method is extremely selective and highly accurate only to chondroitin sulfates. Each component of chondroitin sulfate being tested can actually be identified and seen on a chromatogram, which is a visual representation of the test results. In contrast, the USP CPC (Cetyl Pyridinium Chloride) titration method for chondroitin sulfates has very poor selectivity. (In principle, all sulfated and non-sulfated glycosaminoglycans, proteins, dextran sulfate, and surfactants with suitable molecular weight as polyanion score positively in the CPC titration method.) This means that the current USP method can be ineffective in identifying pure versus adulterated materials, and the test results from this imprecise method could make poor quality or adulterated chondroitin sulfates seem to be identical to better quality material. |
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Everyone old enough to walk appreciates the value of flexibility and ease of movement. Unfortunately many of us take such good things for granted. A famous folksinger sang, "You don't know what you've got till it's gone." That's certainly true for millions Americans who live with stiff and uncomfortable joints. Fortunately there are a number of nutrients available that provide the vital components of healthy joint structure and function and ease of mobility. These nutrients are referred to as “chondroprotective agents,” and include glucosamine and chondroitin, which supply the raw material necessary to produce new cartilage, and may even help rebuild worn cartilage. Other chondroprotective nutrients and herbs, like Cetyl Myristoleate, MSM, and Boswellin, work synergistically with glucosamine and chondroitin and further support normal joint function. To understand how chondroprotective agents work, one must first understand how joints work. The key element in human joints is articular cartilage, the shock-absorbing tissue that connects two bones together and allows pain-free movement. Articular cartilage is comprised of two different molecules, collagen and proteoglycans, with the remainder composed primarily of water (65-85%). Collagen, a protein that binds tissue together, provides elasticity. Proteoglycans, composed of sugars and protein, absorb water, which provides lubrication and resiliency, nature's shock absorber for your joints. Both compounds are produced by chondrocytes, caretaker cells responsible for the formation and maintenance of cartilage. A deficiency in any one of the above constituents will increase the likelihood of wear and tear on articular cartilage, which can eventually lead to compromised joint function. Glucosamine and chondroitin are safe, natural and effective nutrients that support healthy joint function by supplying the materials needed to produce collagen and proteoglycans. GLUCOSAMINE Glucosamine is composed of glucose (a sugar) and glutamine (an amino acid). It is utilized by chondrocytes to form glycosaminoglycans (GSG) and proteoglycans (PG). Both of these constituents attract and bind water into cartilage, increasing resiliency. Research indicates that glucosamine may actually help your body repair damaged or eroded cartilage. A number of studies have been conducted on glucosamine sulfate and glucosamine hydrochloride, with a preponderance of positive results. Glucosamine sulfate is considered the more effective of the two. One study from the University of Liege in Liege, Belgium studied the effects of glucosamine sulfate on 212 patients with knee osteoarthritis. Participants took either 1,500 mg glucosamine or a placebo once daily for three years. The study compared joint-space width at enrollment, one year, and at the study’s conclusion. The 106 patients on placebo had a progressive joint-space narrowing, while participants taking glucosamine experienced no significant joint-space loss, indicating glucosamine may beneficially modify cartilage structure.3 A study published in the journal Osteoarthritis and Cartilage in 1998 investigated the in vitro effects of glucosamine sulfate on proteoglycan and collagen production by chondrocytes taken from osteoarthritic articular cartilage. The results showed “a statistically significant stimulation of PG production by chondrocytes from human osteoarthritic cartilage cultured for up to 12 days in 3-dimensional cultures.” 4 Another study from Italy enrolled eighty inpatients with established OA. They received either 1,500 mg of glucosamine sulfate or placebo daily for 30 days. The patients treated with glucosamine sulfate experienced a reduction in symptoms almost twice as large and twice as fast as those receiving placebo. Researchers also used electron microscopy of patient’s articular cartilage to support this hypothesis. Patients who received glucosamine sulfate showed a picture more similar to healthy cartilage. The researchers concluded that glucosamine sulfate tends to rebuild damaged articular cartilage and restore articular function.5 CHONDROITIN Chondroitin is classified as a glycosaminoglycan. It bonds with collagen to form the basis of connective tissue. Chondroitin helps attract fluid into proteoglycans, thereby bringing nutrients into cartilage and providing shock absorption. While glucosamine helps manufacture and maintain cartilage, chondroitin keeps cartilage from becoming malnourished. Chondroitin works synergistically with glucosamine, and these two nutrients form the basis of most joint health supplements on the market today. A 6-month randomized, multi-center, double-blind, double-dummy study published in 1996 compared the effectiveness of chondroitin versus a popular non-steroidal anti-inflammatory drug (NSAID) in patients with knee osteoarthritis (OA). One hundred and forty-six patients with knee OA were recruited and separated into two groups; an NSAID group and a chondroitin sulfate (CS) group. The NSAID group was given the NSAID and a placebo for the first month, then placebo alone for months 2-3. The CS group was given the NSAID and CS for the first month, and then CS alone for months 2-3. Both groups were then given 1200mg of CS for months 4-6. “Patients treated with the NSAID showed prompt and plain reduction of clinical symptoms, which, however, reappeared after the end of treatment; in the CS group, the therapeutic response appeared later in time but lasted for up to 3 months after the end of treatment. CS seems to have slow but gradually increasing clinical activity in OA; these benefits last for a long period after the end of treatment.” 6 NOW® Foods is your source for natural joint support products. Our Extra Strength Glucosamine & Chondroitin is one of our best-selling products, and we also have combination supplements that include MSM, Concentrace® minerals, and more. We also carry both glucosamine and chondroitin as separate products, as well as in powder and lotion forms. References: -
Balch, James F. et. al. ; Prescription For Nutritional Healing 3rd Edition; Avery; Penguin Putnam; 2000 -
Benedikt, H.; Glycosaminoglycans And Derivatives For Treatment Of Arthritis; Chiropractic Products, May 1997, pp. 92-95 -
Reginster, Jean Yves et. al.; Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial; The Lancet, 2001, Vol. 357, No. 9252 -
Bassleer, C. et. al.; Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro; Osteoarthritis and Cartilage, 1998, 6, 427-434 -
Drovanti, A. et. al.; Therapeutic Activity of Oral Glucosamine Sulfate in Osteoarthritis: A Placebo-Controlled, Double-Blind Investigation; Clinical Therapeutics, Vol. 3, No. 4, 1980, pp. 260-272 -
Morreale, P. et. al.; Comparison of the Antiinflammatory Efficacy of Chondroitin Sulfate and Diclofenac Sodium in Patients with Knee Osteoarthritis; Journal of Rheumatology, 1996, 23:8, pp. 1385-1391 |
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| From the NOW Quality Control Department Chondroitin sulfate (CS) is a major component of our cartilage that helps cushion our joints. It is believed to provide structure, hold water and nutrients, and promote elasticity in cartilage. It also appears to inhibit the enzymes that can destroy cartilage tissue. These properties have made Chondroitin Sulfate a popular dietary supplement for people seeking to nourish their joint tissues. Chondroitin is marketed alone or in combination with other joint supplements, usually with Glucosamine (another compound believed key to cartilage formation and repair).1,2 A significant source of Chondroitin sulfate is animal cartilage. The major commercially available source is bovine (cow). Only bovine sources are used in NOW products because the clinical studies on effectiveness of chondroitin are based on bovine material. Other animal sources are also available from porcine (pork), chicken and shark. The finite source of raw materials, coupled with the recent interest in finding natural substances to aid in the maintenance of joint health, has created a significant demand that affects the availability of CS. NOW Foods has been facing the challenge of not only finding material that meets our strict specifications, but is also reasonably priced. We have obtained supplies of Chondroitin sulfate from various sources. Our Quality Control Group analyses samples from these sources. Quality Control determines the percentage of Chondroitin sulfate present. Results obtained ranged from as little as 2.7% to greater than 90%, with everything in-between. NOW scientists use HPLC instrumentation to qualify raw materials, allowing for much tighter controls on the materials purchased. This enables us to ensure that NOW’s CS products are of the highest quality. TECHNICAL NOTES: The industry-wide methods for analysis of Chondroitin sulfate are titration methods using Cetylpyridinium Chloride or CPC titration from USP3. This is an older limited method which can be tricked by the use of less expensive adulterants, such as the drug heparin. The titration method cannot distinguish between Chondroitin sulfate and other materials, like proteins. Our in-house analysis method consists of an enzymatic digestion of Chondroitin sulfate (a biopolymer) into smaller components, which are then analyzed using High Performance Liquid Chromatography or HPLC. This allows for a more accurate quantitative determination, as the enzyme used is very specific and will digest only Chondroitin. In addition, this method can distinguish between different sources of Chondroitin. This allows for a high level of quality control not previously available. This method was developed by NOW scientists and has been accepted by AOAC International, an FDA-approved contractor and developer of analytical test methods, for further development as a worldwide standard test method for Chondroitin sulfate products. NOW scientists have also developed the already published method for testing Glucosamine, in any form, which is now a Official AOAC International Standard Method.4 References: 1 Deal, CL. Neutraceuticals as Therapeutical Agents in Osteoarthritis. Rheum Dis Clin North Am, 1999; 25:379-395 2 Chavez, ML. Glucosamine Sulfate and Chondroitin Sulfates. Hosp Pharm. 1997;32(9):1275-12858 3 USP 29 : Content of Chondroitin Sulfate Sodium, 2006; 2307 4 J. Zhou, T. Waszkuc, F. Mohammed, C. Ray, R. Buren, W. Wang, H.Nguyen, J. Jabusch, D. Sullivan, X. Kou, Q. Yang, A. Solyom, J. Wang, T. Peng, Q. Zheng, M. Blumhorst, M. Nagarajan, B. Podhola, L. Huang, C. Shevchuk, R. Das, K. Orellana, K. Reif. Determination of Glucosamine in Raw Materials and Dietary Supplements Containing Glucosamine Sulfate and/or Glucosamine Hydrochloride by High Performance Liquid Chromatography with FMOC-Su Derivatization: Collaborative Study. Published in Journal of AOAC INTERNATIONAL, July/August, 2005 |
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 Raw Materials Superior supplements begin with superior raw materials. As the foundation that supports our line of quality products, NOW tests raw materials for contaminants, heavy metals, pesticides and fillers. Our philosophy remains unfaltering; we always start with the purest, freshest raw materials to ensure that the finished product is the best it can be. By partnering with some of the most trusted names in the industry including Lonza, PL Thomas, Cyanotech, Inter-Health, Hoffman LaRoche, Sabinsa and others, NOW is proud to provide unadulterated natural products that are safe, potent and true to their claim. -
Natural Ingredients -
Mad Cow Free -
Growth Hormone Free -
Exacting Heavy Metal and Pesticide Specifications -
Pure, Fresh Raw Materials, Always Good Manufacturing Practices NOW's commitment to Good Manufacturing Practice (GMP) is evident in everything we do. As one of the first companies to receive GMP certification from the NNFA, in addition to being one of the very few to maintain a consistent 'A' rating, we've remained steadfast in our commitment to good manufacturing practices. Our clean, controlled and technologically advanced production facility is regularly inspected by the Food and Drug Administration, and has been certified organic by Quality Assurance International. - Longstanding NNFA GMP "A" Rating
- FDA Inspected
- Organic Certification by QAI
- Clean, Modern, Controlled Production Facility
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Our Price: $10.93
Retail Price: $18.88
You Save: $7.95 each, a 42% Savings! |
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