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Pure Encapsulations

Integral Dermo Correction Serum With System 9
by Pure Encapsulations
30 ml Serum

Provides Superior Skin Care Support*

Our Price: $68.30

Integral Dermo–Correction is a patented topical serum designed to revitalize and invigorate skin with moisturizing, conditioning and softening effects. This novel formula provides a complex combination of synergistic ingredients for versatile support suitable for all skin types, even the most sensitive. A lightweight product that complements any skin care regimen, this serum promotes the appearance of healthy, smooth, and young-looking skin.*

In a 4–week study completed in September 2005 at the Iris Clinical Research Organization located near Paris, France, SYSTEM9 (the patented formula in Integral Dermo-Correction Serum) resulted in excellent consumer satisfaction, where findings included the following:

• 94.5% reported a moisturizing effect*
• 90% reported a skin comforting effect*
• 84% reported smoother skin*
• 84% reported a skin calming effect*
• 82% reported improvement in the appearance of firm skin*
• 77.5% reported that the product promoted the appearance of uniform skin tone*

Furthermore, SYSTEM9 fared better in 9 out of 10 categories when compared to a database of over 10,000 responses to other serums and creams. In a pilot study completed in March 2005 at the Matsukura Clinic and Medical Spa in Tokyo, Japan, results included the following:

• 84% reported improvement in skin hydration*
• 72% reported overall product efficacy*
• 64% reported improvement in the appearance of skin tone*
• 62% reported softening of the skin*
• Over 50% reported benefits for overall skin comfort as well as reduction in the appearance of fine lines and wrinkles*

In this study, positive findings were noted after as early as two weeks of use.

Featuring the following key ingredients:
• Palmitoyl-pentapeptide 3 to reduce the appearance of fine lines and wrinkles*
• Hyaluronic acid and Imperata cylindrical extract for moisturization and hydration*
• A complex of fatty acids and functional oils for skin softness and epidermal comfort*
• Soothing extracts of licorice, hops, myrrh and horsetail*
• Marine glycosaminoglycans to reduce the appearance of dark circles and redness*
• Dipalmitoyl hydroxyproline and hesperitin to support the appearance of skin firmness and tone*
* Vitamins A, C and E and manganese for the appearance of a healthy complexion*

Supplement Facts

	Amount Per Serving	Daily Value
A Proprietary Blend Water, Dimethicone, Polysilicone-11, Cyclomethicone, Squalane, Phenyl Trimethicone, Glycerin, Lignoceryl Erucate, Glycosaminoglycans, Peg-8/SMDI Copolymer, Palmitoyl Pentapeptide-3, Imperata Cylindrica Root Extract, Peg-6 Isostearate, Hesperetin Laurate, Horsetail (Equisetum Arvense) Extract, Hyaluronic Acid, Sesamum Indicum (Sesame) Seed Oil, Ethylbisiminomethylguaiacol Manganese Chloride, Triticum Vulgare (Wheat) Germ Oil, Tocopheryl Acetate, Alteromonas Ferment Extract, Caprylic/Capric/Succinic Triglyceride, Dipalmitoyl Hydroxyproline, Myrrha (Commiphora Myrrh) Extract, Retinol, Triticum Vulgare (Wheat) Germ Extract, Humulus Lupulus (Hops) Extract, Bisabolol, Creatine, Aluminum Benzoate, Dipotassium Glycyrrhizate, Disodium Distyrylbiphenyl Disulfonate, Aluminum Chloride, Sodium Carbomer, HDI/Trimethylol Hexyllactone Crosspolymer, Ammonium Acryloyldimethyltaurate/VP Copolymer, Fragrance, Carbomer, Propylene Glycol, Polysorbate 20, Butylene Glycol, Peg-8, Polysorbate 40, Methylparaben, Propylparaben, Phenoxyethanol, Disodium EDTA, Mica		**

** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet.

Suggested Use

One to four (1-4) pumps topically on the entire face and neck one to two (1-2) times daily, or more as directed by your healthcare practitioner. ... To activate the pump for initial use, simply press down a few times until the serum comes out. To protect the integrity and quality of the serum's specialized ingredients, the pump system contains no serum prior to first use. Apply morning and night, alone or prior to moisturizing.

Warnings

If pregnant or nursing, consult your physician before taking this product. ... Keep out of reach of children. ... Do not use if tamper resistant safety seal is not intact. ... Store in a cool, dry place. ... Avoid direct contact with eyes.

Allergen Info

Contains no hidden coatings, excipients, binders, fillers, shellacs, artificial colors or fragrances. In addition, contains NO dairy, wheat, yeast, gluten, corn, sugar, starch, soy, preservatives or hydrogenated oils.

Applicable Functions

Aging, Dermal Calming, Dermal Soothing, Dry Skin Moisturization, Skin Conditions, Wrinkles

Related Structure Groups

Dermis, Epidermis, Skin

Pure Encapsulations For Sensitive People

Pure Encapsulations was founded to create the highest quality hypoallergenic supplements. There are absolutely no hidden fillers or coatings, binders, shellacs, artificial colors, fragrances or excipients in our products that would disrupt or diminish the bioavailability of any of our ingredients. Furthermore, our products are free of wheat, yeast, gluten, corn, sugar, starch, preservatives or hydrogenated oils.

Since 1991, we have set the standards for providing the highest quality nutritional products and health information available, and have established an unprecedented Quality Control program. Today, our supplements are the choice of over 36,000 health professionals in the U.S. and Europe.

We strongly believe that nutritional supplements should be taken under the guidance of a physician or health professional. The strongest link between our high-potency supplements and consumers is the presence and guidance of a qualified health professional.

In 2004, Pure Encapsulations was acquired by Atrium Biotechnologies Inc. Atrium is a leader and innovator of scientifically developed nutritional supplements and is the center of an advanced global network of specialty ingredients.

Our Quality Control Process

Introduction
We have built our business by producing the finest supplements possible. Ingredient quality, manufacturing excellence and quality control are our most important priorities. We differentiate ourselves by holding our suppliers to the highest standards and by following strict, near-pharmaceutical manufacturing procedures. An industry first, we voluntarily submit all of our encapsulated products to third party laboratories for HPLC validation and provide our customers with the actual documentation in the form of a CD. Pure Encapsulations remains unmatched in pioneering a rigorous, validated quality control program.

Ingredient Quality
Our ingredients are selected solely on the basis of quality and purity, and are provided in their most potent and bioavailable forms. We purchase premium raw materials from Japan, Switzerland, Germany, Italy, France, and of course the U.S. Manufacturers of ingredients must pass rigorous pharmaceutical grade analytical tests to qualify as Pure Encapsulations suppliers.

Pure Encapsulations supplements are hypoallergenic. There are absolutely no hidden fillers or coatings, binders, shellacs, artificial colors, fragrances or excipients in our products that would disrupt or diminish the bioavailability of any of our ingredients. Furthermore, our products are free of wheat, yeast, gluten, corn, sugar, starch, preservatives or hydrogenated oils.

Manufacturing and Quality Control Excellence
We manufacture our supplements in our own state-of-the-art facility in Sudbury, Massachusetts.

The manufacturing protocol at Pure Encapsulations is set forth in standard operating procedures (SOP's) developed in conjunction with ISSI Scientific, Highland Park, NJ, a GMP and GLP consultant serving pharmaceutical companies. Every step of Pure Encapsulations SOP's exceed the standards set forth in the U.S. Pharmacopoeia and the NNFA GMP's. We currently sell over 20% of our production as prescription items in Europe.

Our dedication to cleanliness is obvious from the moment our plant is entered. A large full time staff is dedicated to the task of ensuring that our plant meets the highest standards.

The Quality Control/Assurance department is separate and distinct from the Production Department and has full authority to reject ingredients, reject finished products, and stop production, without the approval of other company management. Pure Encapsulations QC/QA department is headed by a Master of Science in Biology and Chemistry. The QC/QA team consists of 5 full-time employees, including 4 full-time inspectors in production. Each step of the manufacturing process is governed by exacting standards and exceeds the requirements for nutritional supplement manufacturing.

All ingredients are quarantined upon receipt, pending independent certification of analysis, usually by High Performance Liquid Chromatography (HPLC) (unless another method is superior).

All ingredients are bar coded and assigned a unique tracking number. Production batch records are QC'd by three senior managers prior to blending, and specialized software programs provide a failsafe mechanism to prevent mis-identification of ingredients.

All production is performed in sealed humidity- and dust-controlled individual rooms, supplied with Millipore filtered compressed air. All production rooms are serviced by particulate remediation systems. Production rooms are sanitized prior to the commencement of every capsule filling run.

Encapsulation equipment is dismantled and sanitized prior to the commencement of every capsule filling run. This includes scales, mills, blenders, powder fillers, encapsulating machines, capsule counters and balances.

Our high tech equipment performs many functions, including capsule weight checking, deformed capsule rejection and de-dusting.

Finished Product 3rd Party Validation
Our finished products are tested by Integrated Biomolecule Corporation, Vanguard Scientific, Eurofins Scientific and Advanced Food Micro. Each Pure Encapsulations lot is submitted to an independent laboratory for final confirmation of potency and conformance with ingredient levels. We are the only supplement manufacturer that has FDA certified laboratories test every batch of finished encapsulated products. This is an important distinction from companies that use in-house laboratories, use skip-lot testing or test ingredients prior to encapsulations or tableting.

Using the most advanced equipment and test methods including HPLC and MS, these labs certify the potency of every ingredient against our label claims. Each product has been verified to contain what it claims on the label. These tests reflect the potency and purity of the actual Pure Encapsulations supplements recommended by the health professional.

Furthermore, all results are provided in over 200 assays available to all of our customers on CD, verifying our uncompromising standards. All finished products must also pass the USP Microbial Limits Test.

Full Label Disclosure

In 1991, we pioneered the practice of providing complete ingredient disclosure. Accepted industry practice was to hide or omit allergenic fillers or excipients. Our supplement labels have always listed all ingredients. Additionally, if an herbal ingredient is listed, our label details the strength of the standardized extract. Furthermore, our fully reacted minerals are listed by their true elemental weights.

Frequently Asked Questions

Why should I purchase supplements from Pure Encapsulations?
Pure Encapsulations provides its customers with the most effective, hypo-allergenic nutritional ingredients available. We do not compromise quality for any reason. When you order Pure Encapsulations' supplements, rest assured that you and your patients will receive the highest quality supplements available.

Does Pure Encapsulations manufacture their own supplements?
Yes. We manufacture supplements in our own state-of-the-art facility in Sudbury, Massachusetts and maintain an open plant policy to welcome our customers; it's our best marketing tool. Every step of the manufacturing process exceeds the requirements for nutritional supplement manufacturing. Our dedication to cleanliness is obvious from the moment you enter our plant. A large staff is dedicated full-time to the task of ensuring that every inch of our plant meets the highest standards. Every piece of equipment used in the manufacture of our supplements is dismantled and sterilized before each production run. This includes scales, blenders, powder fillers, encapsulating machines and capsule counters.

What are your Quality Control procedures?
We have built our business by producing the finest supplements possible. Ingredient quality, manufacturing excellence and quality control are our most important priorities. We differentiate ourselves by holding our suppliers to the highest standards and by following strict near-pharmaceutical manufacturing procedures. An industry first, we voluntarily submit all of our encapsulated products to third party laboratories for HPLC validation and provide our customers with the actual documentation in the form of a CD. Pure Encapsulations remains unmatched in pioneering a rigorous, validated quality control program.

Where do you source your ingredients?
Our ingredients are selected solely on the basis of quality and purity and are provided in their most potent and bioavailable forms. We purchase premium raw materials from Japan, Switzerland, Germany, Italy, France, and of course the U.S. Manufacturers of ingredients must pass rigorous pharmaceutical grade analytical tests to qualify as Pure Encapsulations suppliers.

Is everything in the capsule listed on the label?
Absolutely. In 1991, we pioneered the practice of providing complete ingredient disclosure (accepted industry practice was to hide or omit allergenic fillers or excipients). Pure Encapsulations supplement labels list all ingredients. Additionally, if an herbal ingredient is listed, our label details the strength of the standardized extract.

Do your products contain wheat, rice, gluten, dairy, fillers, etc?
No. The majority of our products are hypo-allergenic. With only a few exceptions, they contain no dairy, yeast or corn. Additionally, they contain no wheat, gluten, sugar, starch, preservatives or hydrogenated oils. The beta glucan in IsoProtein Plus and PureWeigh PREMEAL Beverage is gluten-free. Furthermore, our products contain no hidden coatings, excipients, binders, fillers, shellacs, artificial colors or fragrance. Other companies may use magnesium stearate, preservatives, BHA or BHT in their products.

What does hypo-allergenic mean?
The term hypo-allergenic is used to describe products that are free of binders, fillers, excipients, dyes, and common allergens.

What is the hypo-allergenic plant fiber used to fill capsules for some products?
The hypo-allergenic plant fiber we use is a pharmaceutical grade alpha cellulose derived from purified specialty grades of wood pulp from Southern pine. Due to the nature of the raw material (wood pulp) and the manufacturing process,it does not contain alcohol, grain, corn, corn starch, sulfa, sulfites, animal products or gluten. In addition, it is free of pesticides and heavy metals. There are no known allergens in this plant fiber.

Your herbal extracts are standardized. What does this mean?
A standardized extract is one that guarantees the precise concentration of what is considered the active, or pharmacological, ingredient of the herb. When an herbal extract is not standardized, the amount of the key constituent cannot be determined nor can it be consistent from one capsule to the next. Herbs that are standardized provide consistent, maximum nutritional benefits.

Do I take my supplements with meals or between meals?
General recommendations can be found in our catalog, on our website, as well as on the label of a product. Typically, amino acids and many botanicals are taken between meals, vitamins and minerals with meals.

Can your products be taken during pregnancy or lactation?
Pure Encapsulations does not make recommendations concerning the use of products during pregnancy or lactation. Some products may have known contraindications, while the effects of others have not been studied.

Are there any known drug-nutrient interactions with any of the products?
We encourage you to visit the Drug Depletions & Interactions portion of Clinical Essentials featured in the Health Library section of our site to obtain information on potential positive or negative interactions between prescription drugs and the particular supplements, vitamins or herbs that interest you.

Do you have any supplements specifically formulated for children?
Our children's line includes PureBears chewable tablet, PediaNutrients, Nutrient 280, EPA/DHA liquid (lemon flavor), DHA Enhance, Optimal Immune, Cognitive & Calming, Ester-C extra, Echinacea Syrup, Probiotic 123 (dairy-free), G.I. Comfort and Complexion Factors. A complete brochure is available at www.PureCaps.com, under the Health Library, under Brochures and Supporting Materials.

Are your products kosher?
Our products are not certified as kosher.

Are your soy products genetically modified?
The GMO Status of our soy-containing products is as follows:

•Soy Isoflavones 40 (40% isoflavones)

•Soy Isoflavones capsules (3% isoflavones)

•Vitamin E (mixed tocopherols)

•Vitamin E (d-alpha tocopherol succinate)

•IsoProtein Plus

•PS100

•Alpha-GPC

What is the difference between Glucosamine Sulfate and Glucosamine Complex?
Glucosamine Complex contains three different forms of glucosamine: glucosamine sulfate, n-acetyl-d-glucosamine, and glucosamine HCl in addition to vitamin C and manganese. Some healthcare professionals feel that this provides broad-spectrum joint support not achieved with Glucosamine Sulfate alone. Glucosamine Sulfate remains the most well-researched form of glucosamine.

What is the difference between glucosamine HCl and glucosamine sulfate?
Glucosamine sulfate is a form of glucosamine that is easily absorbed and has been extensively studied. Potassium chloride is added to provide product stability. Some professionals believe that their clients may experience enhanced joint support from the sulfate and potassium that this particular form provides. Glucosamine HCl is believed to be a slightly more stable form of glucosamine and has been only recently studied for joint support. Both have been shown to support joint health.

How do I know which joint support product is best for me?
For the most part, this may involve some experimentation. There is no easy way to determine which product might be the most beneficial for each individual. Products that provide important building blocks include Chondroitin sulfate, Glucosamine Sulfate, Glucosamne HCl, EPA/DHA-Glucosamine, Cartilage Factors, Bovine Cartilage, Arthred, Collagen JS, MSM, Glucosamine/MSM with joint comfort herbs, Glucosamine Chondroitin with manganese, Glucosamine Chondroitin with MSM and Glucosamine Complex. Support for joint comfort and the tissues that surround the joint include EPA/DHA essentials, Boswellia, Glucosamine/MSM with joint comfort herbs, Ligament Restore, Systemic Enzyme Complex, CMO, Ginger, Devil's Claw and Curcumin.

If I am allergic to sulfa drugs, can I take your sulfate products (e.g. glucosamine or chondroitin sulfate)?
Absolutely. A sulfa drug is any of a class of synthetic chemical substances derived from sulfanilamide and used to treat bacterial infections. These drugs inhibit the action of para-aminobenzoic acid, a substance bacteria need in order to reproduce. Glucosamine sulfate is not a sulfa drug. It is an amino sugar naturally found in cartilage matrix. As a dietary supplement, it promotes optimal joint health.

If I am allergic to shellfish, can I take Glucosamine Sulfate or Chitosan?
Most of our glucosamine products and chitosan are sourced from the chitin (hard shell) of crab and other shellfish. It may be best to avoid these products if you have an allergy. We do, however, have a shellfish-free Glucosamine HCl, derived from corn fermentation.

What is the difference between citrates, aspartates, glycinates, malates and picolinates?
Aspartates, citrates, malates, glycinates, and picolinates are superior forms of chelates because they are organic compounds (carbon-containing), which are better absorbed by the body. Most of these chelates are also krebs cycle intermediates, supporting the body's metabolic processes. Minerals chelated with inorganic compounds such as carbonate are not as well absorbed.

Technically, aspartate and glycinate are considered "amino acid chelates". Citrate, malate, and picolinate are not amino acid derivatives and are not categorized as amino acid chelates. Nonetheless, each of these is an organic chelate and most are krebs cycle intermediates supporting optimal absorption.

At this time, studies have not compared the effects of aspartates vs. citrates vs. malates vs. glycinates vs. picolinates enough to know whether a significant difference exists between theseforms. It is believed, however, that any of these organic compounds and krebs cycle intermediates have the potential to be better absorbed than other forms.

Is the fish oil microfiltered (molecularly distilled)? Has it been tested for heavy metals?
Yes, the fish oil used in EPA/DHA Essentials is molecularly distilled. Additionally, we test each batch for 17 dioxins and furans, 14 PCBs, peroxides, anisidines and microbial contaminants. Additionally, we test for heavy metals, including lead, cadmium, arsenic and mercury at levels exceeding industry standards. Our fish oil is sourced from sardines and anchovies from the Pacific Ocean off the coast of Chile.

Why is your garlic standardized to contain scordinin? Does it contain allicin?
Many extracts are standardized to contain allicin, a sulfur-containing compound. Scordinin is also a sulfur-containing compound but is believed to be more stable. The health benefits of scordinin are documented by Japanese research. Pure Encapsulations Garlic 100:1 contains 5.3 mg of scordinin per capsule.

One capsule of our Garlic 100:1 provides the equivalent of approximately 25 grams, or one head (12 cloves), of garlic. The allicin content is 15-30ppm. This equates to 0.375-0.750 mg allicin per capsule.

What is the difference between Panax ginseng and Eleutherococcus senticosus?
It is believed that Panax ginseng (also known as Asian ginseng) may produce a more immediate, stimulating effect than Eleutherococcus senticosus, which may have a calming, tonifying effect. The difference lies primarily in their active compounds. Panax ginseng is standardized to contain 27-30% total ginsenosides whereas Eleutherococcus senticosus is standardized to contain 0.8% eleutheroside E and B. Also, some professionals do not recommend Panax ginseng for female patients because of possible masculinizing effects.

Have your bovine-sourced products been tested for mad cow disease?
As a manufacturer of the highest quality nutritional supplements, Pure Encapsulations management and quality control personnel have (since the company's inception in 1991) purchased bovine ingredients from the US, New Zealand and Argentina.

All Pure Encapsulations bovine products are inspected by the USDA and certified to be safe prior to our accepting them into our inventory.

There is no practical or theoretical possibility of contracting BSE from any Pure Encapsulations supplement.

What is the difference between Ginkgo 250 and Ginkgo 50? Ginkgo 50 and Ginkgo 32/9?
Ginkgo 250 was the first ginkgo extract introduced to the U.S. It is an 8:1 extract. This means that 8 units of ginkgo leaves were needed to produce 1 unit of extract. Since then, standardized, higher potency ginkgo extracts have been introduced. Ginkgo 50 is an extract standardized to contain 6% terpene lactones and 24% ginkgoheterosides. It is a 50:1 extract, indicating that 50 units of ginkgo leaves were needed to make 1 unit of ginkgo extract. Ginkgo 32/9 is the highest potency extract available. It is standardized to contain 32% terpene lactones and 9% ginkgoheterosides and is a 67:1 extract.

What is the difference between Vitamin E and Tocotrienols?
Eight different compounds, 4 tocopherols (alpha, beta, delta, and gamma tocopherols) and 4 tocotrienols (alpha, beta, delta, and gamma tocotrienols) make up the vitamin E family. These eight members have some functions that are similar (both provide powerful antioxidant activity) and some functions that are different (vitamin E plays a crucial role in the cellular respiration of cardiac muscles, while tocotrienols maintain healthy lipid metabolism). Until recently, d-alpha tocopherol was the member of this family most associated with vitamin E. This is mostly due to the fact that it is the most abundant form. Now, the other forms of tocopherol are receiving attention in addition to the tocotrienol members of the family, especially gamma tocotrienol.

Why do you offer Nutrient 950 w/out iron, copper or iodine? With NAC?
Postmenopausal women and most men do not need iron supplementation, and many individuals do not need additional copper or iodine. We added Nutrient 950 with n-acetyl-cysteine (NAC) because we make it by request for a large physician group and wanted to offer it to all other healthcare professionals.

What is the difference between Nutrient 950 and UltraNutrient?
UltraNutrient combines the core ingredients of Nutrient 950 with advanced antioxidants and standardized phytonutrient extracts to provide a supplement of unequalled potency and effectiveness. These ingredients include mixed carotenoids, vitamin C as ascorbyl palmitate, milk thistle, reduced glutathione, hawthorn, coenzyme Q10, alpha lipoic acid, taurine, and ginger.

On the labels for Buffered Ascorbic Acid products, it indicates that 1,000 mg buffered ascorbic capsules provides 500 mg vitamin C or that 4,400 mg buffered ascorbic acid powder provides 2,200 mg vitamin C. What are the remaining mg made up of?
This formula is buffered with mineral ascorbates (calcium, magnesium and potassium ascorbates) to create a neutral pH vitamin C for sensitive individuals. The remaining mg are an excellent source of these minerals.

Is Growth Hormone Support Formula safe for children?
This product is not recommended for use by children.

Can 5-HTP and St. John's wort or Ginkgo be taken together?
In The Natural Way to Overcome Depression, Obesity, and Insomnia, Dr. Michael Murray indicates that individuals may take 300 mg St. John's wort extract (0.3% hypericin) three times daily or Gingko extract (standardized to contain 24% ginkgoheterosides) in the amount of 80 mg three times daily to enhance the effects of 5-HTP for emotional well-being.

Why is the ratio of magnesium to calcium in +CAL+ with Ipriflavone low?
+Cal+ with Ipriflavone provides a very complete formulation of calcium and the various nutritional elements best known for osteoporosis support. The inclusion of additional magnesium would require the elimination of other important co-factors for bone metabolism that make this formula so effective. Magnesium is relatively inexpensive and can easily be obtained from one of our magnesium supplements, including Magnesium citrate, aspartate or glycinate. In addition, it is available as Potassium/Magnesium and Calcium/Magnesium.

I ordered some of your probiotics and they have been left unrefrigerated for a few days. Are they still viable?
Our refrigerated probiotics are packaged in specialty insulated boxes with cold packs to maintain proper temperature and viability. Furthermore, capsules are manufactured to contain 20-30% more of the probiotic culture than indicated on the label to ensure full activity by the time it reaches you.

Is Calcium-d-Glucarate helpful for supporting healthy bones?
Calcium-d-Glucarate supports healthy cell structure and function by helping to target beta-glucuronidase activity, supporting the process by which healthy cells eliminate waste and foreign elements. Calcium-d-Glucarate only contains 12% calcium and is not used for bone health. Osteoporosis support formulas include Calcium Citrate, Calcium Citrate/Malate, Calcium Aspartate, Calcium (microcrystalline hydroxyapatite), Calcium Magnesium Aspartate, Calcium Magnesium Citrate, Calcium Magnesium Citrate/Malate, +CAL+ with Ipriflavone, Ipriflavone with Vitamin D3, OsteoBalance and Cal/Mag w/Cofactors (powder).

Is your CoQ10 the cis or trans configuration?
Pure Encapsulations' CoQ10 is obtained naturally by fermentation. A series of crystallization and evaporation steps follows in order to achieve optimal purification. This results in the production of CoQ10 with a side chain of 10 isoprenoid units in the trans configuration, the form of CoQ10 that occurs naturally in the body's cells.

What are your vitamin C products derived from?
Vitamin C contained in Pure Encapsulations Pure Ascorbic Acid, Ascorbyl Palmitate, and Buffered C is derived from corn dextrose fermentation. Sensitivity to this product, even for people with a sensitivity to corn, is rare since the protein has been removed.

What products help to support healthy lipid and/or triglyceride metabolism?
There are a variety of products we carry that fall into this category, including CholestePure, EPA/DHA essentials, Pantethine, Policosanol, Pantethine/Policosanol, Niacitol, Guggul, Sytrinol, UltraHeart, Garlic, Fenugreek 85, Tocotrienols, LinumLife and IsoProtein Plus.

What is the source of your Veggie Capsules?
The capsules are made from Southern Pine, grown in the US. The pine is pesticide free.

How much CoQ10 should I take if I am on statin drugs?
Statin drugs have been shown to interfere with your body's production of CoQ10 and the amount suggested by Julian Whitaker, M.D., is 100-200 mg per day.

Does your borage oil contain Pyrrolizidine alkaloids (PA)?
Pyrrolizidine alkaloids (PAs) are found in very small amounts in the oils derived from borage seeds. PAs are soluble in both water and alcohol, but not very soluble in the oil.

There are only 0.002 mcg PAs/maximum dose of our borage oil. This is less than what the German Health agency recommends, which is 1 mcg/day of PAs.

Is d-mannose safe for diabetics?
D-mannose is very safe, even for long term use (even though most people will only need to use it for several days or weeks). Although it is a simple sugar, very little of it is metabolized. It does not interfere with blood sugar regulation even for diabetics, though close monitoring is always advised. It creates no disruption or imbalance in normal microflora.

Does Pure Encapsulations carry calcium derived from coral?
No, we do not carry coral calcium. Coral calcium is composed of calcium carbonate and its absorption is based on the known properties of any calcium carbonate supplement. Calcium carbonate contains 40% calcium by weight as opposed to calcium citrate, which contains 21% calcium. However, the key difference between these two forms of calcium is their bioavailability. Calcium carbonate requires a substantial amount of acid to pry off the carbonate chelate and allow the calcium to be absorbed. Calcium citrate, on the other hand, is already acidic and therefore does not require a low pH in order to render the calcium available for absorption. Thus, while calcium carbonate supplements contain more calcium by weight, the majority of it is unavailable for tissue uptake. This can be a particularly important point when searching for the right calcium supplement, especially for those with low gastric acid levels common with aging. Even those with healthy stomach acid levels typically only absorb 22% of the calcium in calcium carbonate, whereas people with insufficient gastric acid output may only absorb 4%. In contrast, 45% of the calcium is absorbed from calcium citrate in people with low stomach acid.

Multiple studies have demonstrated an enhanced bioavailability of calcium citrate compared to calcium carbonate. Chelating with Krebs cycle intermediates, such as citrate, aspartate, and malate allows calcium to be easily absorbed and enhances the absorption of other minerals. Pure Encapsulations offers Calcium (citrate) and Calcium Magnesium (citrate), Calcium (citrate/malate) and Calcium/Magnesium (citrate/malate), and Calcium (aspartate) and Calcium/Magnesium (aspartate). All Pure Encapsulations calcium supplementsare tested for heavy metals.

How does Pure Encapsulations Cranberry NS compare to cranberry juice?
Cranberry NS is a sugar-free, low-calorie alternative to commercial cranberry juice cocktails, which usually contain at least 30% sugar. Each Cranberry NS capsule has approximately three calories. 1 capsule of cranberry extract=10 oz Cranberry juice cocktail.

What is the source of Neuromins DHA?
Neuromins DHA from Pure Encapsulations is extracted from microalgae under tightly controlled manufacturing conditions. The microalgae is Crypthecodinium cohnii, a non-GMO phytoplankton dinoflagellate.

Why is sunflower oil added to Neuromins DHA?
Sunflower oil is included to stabilize the DHA oil and to ensure consistent potency from batch to batch. DHA is extracted from algae, providing a 40-50% DHA concentrate. DHA above 40% is blended with sunflower oil in order to provide product stability and consistency. Vitamin E and ascorbyl palmitate are also added to further enhance stability.

How many milligrams of caffeine are in one serving of PureWeigh PREMEAL? How many milligrams of caffeine are in each capsule of PureWeigh FM?
PureWeigh PREMEAL contains 5 milligrams of caffeine per serving. PureWeigh FM contains 12 milligrams of caffeine per capsule.

What is the TOA and POA content of Cat's claw?
The content of TOAs (or tetracyclic oxindole alkaloids) is 0.27% and the content of POAs (pentacyclic oxindole alkaloids) is 2.73%.

What is the source of hesperidin? What is the difference between hesperidin methyl chalcone and hesperidin?
Hesperidin methyl chalcone is derived from sweet orange.

There are essentially three forms of hesperidin: hesperidin complex, purified hesperidin and hesperidin methyl chalcone, like we have. The three forms of hesperidin differ in terms of water solubility. For hesperidin methylchalcone, hesperidin from sweet orange is made alkaline to achieve hesperidin chalcone. Then in a synthetic step, the compound is methylated, providing a product that is no less than 98% hesperidin methyl chalcone. This is the most water soluble and therefore readily absorbable form for the bloodstream.

Why are the calcium supplements only 150 mg per capsule? I have to take 6-7 capsules to achieve 900 mg, and most recommendations are for 1,000-1,500 mg.
Pure Encapsulations uses the most bioavailable calcium chelates available, including citrate, citrate/malate, and aspartate. These forms of calcium have been shown to be more bioavailable than calcium carbonate, especially for individuals with low stomach acidity.

Calcium citrate and the other calcium chelates that we use in our line take up considerable volume, resulting in a maximum capsule capacity of 150 mg elemental calcium (however, remember they are more absorbable). Because we do not use tablets, which contain excipients, fillers, shellacs, artificial preservatives, etc, we cannot compress this powder to provide a higher dosage per serving. Also, calcium is best absorbed and utilized when it is taken in several divided doses throughout the day. Six or seven capsules can be easily divided into two servings consisting of 3 capsules in the morning and 3 capsules in the evening, or 3 capsules in the morning and 4 capsules in the evening, respectively. Or, it can be taken in 3 or 4 divided doses daily, depending on compliance.

Dietary sources of calcium can enhance calcium intake to help meet the requirements of each individual as needed. For example, one 8 oz serving of plain lowfat yogurt contains 350 mg calcium, one cup of skim milk contains about 300 mg calcium, and 8 oz orange juice with calcium provides 350 mg calcium.

Is the pancreatin in Pancreatic Enzyme formula processed such that it contains lactose?
Our full-strength pancreatin does not contain lactose. At full-strength, the product is designated as "10x". When pancreatin products are not full-strength, such as "4x", they are "diluted" with either lactose or sucrose, as specified by the USP.

What is the difference between pantethine and pantothenic acid (calcium pantothenate) and can pantethine be used for adrenal support?
Pantothenic acid is a single molecule whereas pantethine is a double molecule. Panthethine consists of two molecules of pantothenic acid, which are also attached to molecules of cysteamine. Cysteamine is believed to play the primary role in the cardiovascular support properties of pantethine, and pantothenic acid primarily serves as a stable carrier for cysteamine. When digested, pantethine is hydrolyzed into cyteamine and two molecules of pantothenic acid. In addition to cardiovascular health, panthethine may be helpful for supporting similar applications as calcium pantothenate, including adrenal support.

What are the sources of your B vitamins?
The sources of our B vitamins are as follows:

Is chromium picolinate safe?
An independent toxicological laboratory in Cambridge, Massachusetts assessed the toxicity of chromium picolinate and found no production of chromosomal damage.

Furthermore, the concentration of chromium picolinate used in this study was thousands of times greater than the amount used for human supplementation. Some rat studies have used doses of chromium picolinate 5,000 times and 80,000 times greater than a typical human dose of 200 mcg, without adverse effects.

In addition, the safety of chromium picolinate has been clearly established in over 25 formal peer reviewed and published studies.

Do you carry SAMe?
Pure Encapsulations has explored the opportunity to provide SAMe. Unfortunately, SAMe is a very unstable product and even more so in encapsulated form (as opposed to enteric tablets) without the use of excipients, preservatives and fillers. At this time, we have decided that it is not in our best interest to carry this highly unstable product, even though there are a number of clinical trials demonstrating positive results with SAMe. Several options for supporting emotional well-being include Hypericum, PS100, Acetyl-l-carnitine, Cognitive Aminos and l-Theanine. For joint support, we provide a variety of formulations including Glucosamine sulfate, Chondroitin Sulfate, MSM, Glucosamine/Chondroitin/MSM, Glucosamine/Chondroitin with manganese, Glucosamine/MSM with joint comfort herbs, Boswellia, Arthred, and others.