NOW Foods - Joint And Immune Enhancers
NOW Foods' Immune System Enhancers, Joint Support And Minor Pain Relief Nutritional Supplements
http://www.nowfoods.com

Immune Renew
by NOW Foods - Joint And Immune Enhancers
90 Vegetarian Capsules

Formulated With Eight Remarkable Organic Mushrooms*

Our Price: $12.14
Retail Price: $20.98
You Save: $8.84 each, a 42% Savings!

Immune Renew™ by NOW is a potent immune system supporting formulation containing Standardized Astragalus Extract and a High Beta-Glucan Proprietary Mushroom Blend Astragalus has been shown in non-clinical studies to support a number of aspects of healthy immune function, including the enhancement of T-Cell and Natural Killer Cell activity. Natural killer cells are so named because they destroy unhealthy cells in the body virtually on contact.*

NOW's Proprietary Blend of eight organic mushrooms provides additional immune support due to its high 1,3 Beta Glucan content. 1-3 beta glucans are especially valuable to immune system response, though they're increasingly lacking in today's typical diet. Scientific studies have demonstrated that the 1,3 form of Beta Glucan found in mushrooms possesses remarkable abilities to support both innate and adaptive immunity. A strong, responsive immune system in the foundation of good health.*

Supplement Facts


One (1) Vegetarian Capsule Contains:	Amount Per Serving
Mushroom Blend Organic (Optimal Mycelial BioMass):	200 mg
Turkey Tail (Coriolus versicolor)
Sun Mushroom (Agaricus blazei)
Maitake Mushroom (Grifola frondosa)
Cordyceps Mushroom (Cordyceps sinensis)
Phellinus linteus
Lions Mane (Hericium erinaceus)
Reishi Mushroom (Ganoderma lucidum)
Shiitake Mushroom (Lentinus edodes)
Astragalus Root Extract (Astragalus membranaceus) (min. 70% Polysaccharides)	200 mg

Other Ingredients

Silica, Magnesium Stearate (vegetable source), Cellulose (veggie cap), Cellulose, Contains no sugar, salt, wheat, gluten, corn, soy, milk, egg or preservatives.

Suggested Use

As an herbal dietary supplement, one (1) capsule, one to two times (1-2x) daily, or as directed by a healthcare practitioner.

Applicable Functions

Immune Impairment, Low Energy, Recurring Illness

Related Structure Groups

Central Nervous System, Immune System, Lymphatic

Related Emotions

Burnt Out, Frazzled, Overwhelm

Immune Renew Fact Sheet

Neil E. Levin, CCN, DANLA

02/10/05

LIKELY USERS: Everyone seeking a healthy immune system; People on low carb diets or non-whole grain diets that are lacking dietary beta-glucans

KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg). Proprietary blend of 8 organically grown “medicinal mushrooms” (200 mg)

MAIN PRODUCT FEATURES: Vegetarian formula. Polysaccharides in these US-grown mushrooms grown on organic brown rice include 1,3 Beta-glucans and terpenoids. Beta-glucans may stimulate the immune system in different ways. Triterpenoids may act as mild anticoagulants. Each mushroom may have a different effect; for example, one may stimulate T-cells and another Natural Killer cells, aiding in immune defense. Mushrooms have reported beneficial effects on liver health and promoting normal cell growth.

ADDITIONAL PRODUCT INFORMATION: Some extracts from these kinds of mushrooms have been used medicinally in Japan and China. The mushrooms include Turkey Tail, Sun Mushrooms, Maitake, Cordyceps, Phellinus, Lion’s Mane, Reishi and Shiitake. The astragalus extract also contains naturally occurring astragalosides. Mushrooms may help maintain normal cholesterol and triglyceride levels

SERVING SIZE & HOW TO TAKE IT: For everyday use take one or two caps per day, either with meals or on an empty stomach.

COMPLEMENTARY PRODUCTS: Vitamin C to break down beta-glucan structures for better absorption, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and antioxidants

CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease. Use with caution if using anticoagulants or blood pressure medication, as these mushrooms may have mildly synergistic effects to those drugs. Do not use if you have mold or mushroom allergies (or any sensitivities to mushrooms, cheese, etc.), which can potentially result in hives, rashes, breathing difficulties (including dry mouth or throat), stomach distress, diarrhea, or any other unusual side effect.

This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995

2. Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol. 1999;19(1):65-96.

3. Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002 Nov;60(3):258-74. Epub 2002 Sep 10.

4. Nanba H, Hamaguchi AM, Kuroda H. The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake). Chem Pharm Bull 1987;35:1162–8.

5. Yamada Y, Nanba H, Kuroda H. Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake). Chemotherapy 1990;38:790–6.

6. Nanba H. Immunostimulant activity in vivo and anti-HIV activity in vitro of 3 branched b-1–6-glucans extracted from maitake mushrooms (Grifola frondosa). VIII International Conference on AIDS, Amsterdam, 1992 [abstract].

7. Kubo K, Nanba H. Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. Biol Pharm Bull 1997;20:781–5.

8. Adachi K, Nanba H, Otsuka M, Kuroda H. Blood pressure lowering activity present in the fruit body of Grifola frondosa (maitake). Chem Pharm Bull 1988;36:1000–6.

9. Jones K. Shiitake: A major medicinal mushroom. Alt Compl Ther 1998;4:53–9 [review].

10. Taguchi I. Clinical efficacy of lentinan on patients with stomach cancer: End point results of a four-year follow-up survey. Cancer Detect Prevent Suppl 1987;1:333–49.

11. Matsuoka H, Seo Y, Wakasugi H, et al. Lentinan potentiates immunity and prolongs survival time of some patients. Anticancer Res 1997;17:2751–6.

12. Guangwen Y, Jianbin Y, Dongqin L, et al. Immunomodulatory and therapeutic effects of lentinan in treating condyloma acuminata. CJIM 1999;5:190–2.

13. Jones K. Reishi mushroom: Ancient medicine in modern times. Alt Compl Ther 1998;4:256–66 [review].

14. Kammatsuse K, Kajiware N, Hayashi K. Studies on Ganoderma lucidum: I. Efficacy against hypertension and side effects. Yakugaku Zasshi 1985;105:531–3.

15. Jin H, Zhang G, Cao X, et al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Nimmi H, Xiu RJ, Sawada T, Zheng C. (eds). Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science, 1996, 131–8.

16. Suzuki H, et al. Immunopotentiating Substances in Lentinus edodes Mycelial Extract(LEM)-- Activation of Macrophage and Proliferation of Bone Marrow Cell. Nippon Shokakibyo Gakkai Zasshi. Jul1988;85(7): 1430.

17. Suzuki H, et al. Inhibition of the Infectivity and Cytopathic Effect of Human Immunodeficiency Virus by Water-soluble Lignin in an Extract of the Culture Medium of Lentinus edodes Mycelia (LEM). Biochem Biophys Res Commun. Apr1989;160(1):367-73.

18. Gordon M, et al. A Placebo-controlled Trial of the Immune Modulator, Lentinan, In HIV-positive Patients: A Phase I/II Trial. J Med. 1998;29(5-6):305-30.

19. Li JF, et al. Study on the Enhancing Effect of Polyporus Polysaccharide, Mycobacterium Polysaccharide and Lentinan on Lymphokine-activated Killer Cell Activity in vitro. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Apr1996;16(4):224-26.

20. Li KR, et al. Anti-atherosclerotic Properties of Higher Mushrooms (a Clinico-experimental Investigation. Vopr Pitan. Jan1989;1:16-19.

21. Shouji N, et al. Anticaries Effect of a Component From Shiitake (An Edible Mushroom). Caries Res. Feb2000;34(1):94-98.

22. Levy AM. Eosinophilia and Gastrointestinal Symptoms After Ingestion of Shiitake Mushrooms. J Allergy Clin Immunol. May1998;101(5):613-20.

23. Zjawiony JK. Biologically active compounds from Aphyllophorales (polypore) fungi. J Nat Prod. 2004 Feb;67(2):300-10.

24. Oliva D. Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini Rev Med Chem. 2004 Oct;4(8):873-9.

25. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.

26. Borchers AT, Stern JS, Hackman RM, Keen CL, Gershwin ME. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med. 1999 Sep;221(4):281-93.

27. Mau JL, Lin HC, Chen CC. Antioxidant properties of several medicinal mushrooms. J Agric Food Chem. 2002 Oct 9;50(21):6072-7.

28. Hirasawa M, Shouji N, Neta T, Fukushima K, Takada K. Three kinds of antibacterial substances from Lentinus edodes (Berk.) Sing. (Shiitake, an edible mushroom). Int J Antimicrob Agents. 1999 Feb;11(2):151-7.

29. Rajewska J, Balasinska B. Biologically active compounds of edible mushrooms and their beneficial impact on health. Postepy Hig Med Dosw (Online). 2004 Oct 5;58:352-7.

30. Chang R. Functional properties of edible mushrooms. Nutr Rev. 1996 Nov;54(11 Pt 2):S91-3.

31. Lin ZB, Zhang HN. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin. 2004 Nov;25(11):1387-95. PMID: 15525457

32. Cheung NK, Modak S, Vickers A, Knuckles B. Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies. Cancer Immunol Immunother. 2002 Nov;51(10):557-64. Epub 2002 Sep 20. PMID: 12384807

33. Shamtsyan M, Konusova V, Maksimova Y, Goloshchev A, Panchenko A, Simbirtsev A, Petrishchev N, Denisova N. Immunomodulating and anti-tumor action of extracts of several mushrooms. J Biotechnol. 2004 Sep 30;113(1-3):77-83.
PMID: 15380649

34. Zhang YD, Shen JP, Zhu SH, Huang DK, Ding Y, Zhang XL. Effects of astragalus (ASI, SK) on experimental liver injury
Yao Xue Xue Bao. 1992;27(6):401-6. Chinese. PMID: 1442065

35. Sheng BW, Chen XF, Zhao J, He DL, Nan XY. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves. Chin Med J (Engl). 2005 Jan;118(1):43-9. PMID: 15642225

36. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol. 2005 Jan 4;96(1-2):71-7. PMID: 15588652

37. Li C, Cao L, Zeng Q. Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):379-84. PMID: 15587404

38. Wang SH, Wang WJ, Wang XF, Chen W. [Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Oct;24(10):926-8. Chinese. PMID: 15553830

39. Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 2004 Oct 8;323(1):133-41. PMID: 15351712

40. Mao SP, Cheng KL, Zhou YF. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3. Chinese. PMID: 15015443

41. Guo FC, Williams BA, Kwakkel RP, Li HS, Li XP, Luo JY, Li WK, Verstegen MW. Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poult Sci. 2004 Feb;83(2):175-82.

Beta Glucans

By Lou DeMers and Neil Levin, NOW Quality Assurance Dept.

Immune response relies on the stimulation of macrophages – white blood cells that scour the body on ‘search and destroy’ missions targeting harmful bacteria. Unfortunately, these “Special Forces” are not always on duty - they must first be activated. And that’s the role of beta-glucans. They give the “go order” to the body’s macrophages. The more beta-glucans in the system, the more macrophages will be called into action. *

TECHNICAL TALK ABOUT BETA GLUCANS

Polysaccharides containing D-glucose as the only monomer are commonly referred to as D-glucans. Starches, Glycogen and Cellulose are chemically ‘glucans’; but the glucose molecules are 1,4-linked and are not the immuno-stimulant type of “glucans”.

The immunostimulatory b-glucans however, are those in which the glucose molecules are 1,3-linked, and are commonly known as b-glucans. When the b-1,3-linkage glucose molecules have branches attached in position 6 of the glucose in the backbone chain, they are defined as the b-1,3/1,6-D-glucans. These glucans exist in foods such as oats, barley, and some medicinal mushrooms but the NOW Foods’ product is derived from the cell walls of Baker’s Yeast (Saccharomyces cerevisiae).

Polysaccharide tests have been designed to distinguish between the different types of glucose linkages, and therefore make it possible to identify the type of glucan in question. NOW Foods utilizes such testing to ensure its customers are receiving the immuno-stimulatory b-glucan with the appropriate activity.

NOW PRODUCTS CONTAINING BETA GLUCANS

Beta 1,3/1,6- D -Glucan 100 mg

Product # 3054NOW

NOW Beta 1-3 Glucan formula is comprised of the most concentrated sources available – Saccharomyces Cerevisae (the inner cell walls of baker’s yeast) and Maitake mushroom. As research evolves, consumers are increasingly turning to beta-glucans to give their immune function added firepower.*

Immune Renew

Product # 3055NOW

NOW® Immune Renew™ is a potent immune system supporting formulation containing Standardized Astragalus Extract and a High Beta-Glucan Proprietary Mushroom Blend Astragalus has been shown in non-clinical studies to support a number of aspects of healthy immune function, including the enhancement of T-Cell and Natural Killer Cell activity. Natural killer cells are so named because they destroy unhealthy cells in the body virtually on contact.

Fermented Soy Powder

Product # 2060NOW

NOW® Fermented Soy Powder combines the nutritive value of soy with the benefits of fermentation in one convenient daily serving. Fermented Soy offers a broader nutrient profile than traditional soy products with its higher content of bioavailable isoflavones, including Genistein and Daidzein. Fermentation also produces pre-digested soy protein, which naturally improves flavor and texture.

Disclaimers: These statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Reference:

Textbook of Organic Chemistry, 1942, pp198-201

Organic Chemistry - An Advanced Treatise, 1949, pp 1664-1667

London South Bank University, March 13, 2005 internet update

Beta-Glutans, www.nnfa.org/services/science/bg_betaglucans.htm

Yeast Beta-D-Glucan,www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/yea_0298.shtml

Beta-Glutan, www.vitacost.com/science/hn/Supp/Beta_Glucan.htm

Assaying beta-glucans, Complex Carbohydrate Research Center, University of Georgia-Athens

NOW Foods - Immune System Enhancers

The human body is constantly being exposed to toxins and bacteria that can pose any number of health threats ranging from very mild to very serious. Our immune system works tirelessly to identify and fight these harmful compounds, while protecting us from illness, infection and disease. A healthy immune system also remembers what viruses it has been exposed to, making it even easier to prevent the possibility of recurrence. Our line of immune system support products can be essential in fueling the immune system with the nutriton it needs to flourish.

NOW Quality

Raw Materials

Superior supplements begin with superior raw materials. As the foundation that supports our line of quality products, NOW tests raw materials for contaminants, heavy metals, pesticides and fillers. Our philosophy remains unfaltering; we always start with the purest, freshest raw materials to ensure that the finished product is the best it can be. By partnering with some of the most trusted names in the industry including Lonza, PL Thomas, Cyanotech, Inter-Health, Hoffman LaRoche, Sabinsa and others, NOW is proud to provide unadulterated natural products that are safe, potent and true to their claim.

Natural Ingredients
Mad Cow Free
Growth Hormone Free
Exacting Heavy Metal and Pesticide Specifications
Pure, Fresh Raw Materials, Always

Good Manufacturing Practices

NOW's commitment to Good Manufacturing Practice (GMP) is evident in everything we do. As one of the first companies to receive GMP certification from the NNFA, in addition to being one of the very few to maintain a consistent 'A' rating, we've remained steadfast in our commitment to good manufacturing practices. Our clean, controlled and technologically advanced production facility is regularly inspected by the Food and Drug Administration, and has been certified organic by Quality Assurance International.