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Hyaluronic Acid
by Doctors Best
60 Capsules
Helps Support Healthy Skin And Joint Function*
Our Price: $11.43
Retail Price: $19.99
You Save: $8.56 each, a 43% Savings! | 
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Best Hyaluronic Acid with Chondroitin Sulfate contains patented BioCell Collagen II. Sourced from chicken sternal cartilage, BioCell Collagen II contains key components that can help support healthy skin and joint function. It is hydrolyzed and denatured to provide highly bioavailable, low molecular weight glycosaminoglycans (GAGs). BioCell Collagen II is standardized to contain 20% Chondroitin Sulfate, 10% Hyaluronic Acid and 60% Collagen Type II. Hyaluronic Acid and Collagen are vital structural components of skin that decline as we age, and are responsible for the skin’s moisture, suppleness and elasticity.* Supports Healthy Joint Structure and Function
Components of BioCell Collagen II, including collagen type II, chondroitin sulfate and hyaluronic acid (HA), can enhance proteoglycans in the joint matrix, thereby providing support for healthy joint function and maintaining joint shock absorption and cushioning.* Chondroitin Sulfate
Chondroitin has been well studied for its effects on joint health. In a 1996 controlled, double-blind trial published in the Journal of Rheumatology, 146 volunteers consumed chondroitin sulfate daily for 6 months. Changes in joint function were measured according to several clinical parameters and carefully analyzed. After the first month, significant improvements were noted and maintained for three months after the subjects stopped taking the chondroitin sulfate. In an earlier double-blind study subjects taking chondroitin sulfate had improvements in joint function after three months of use, as determined by both objective and subjective measurements. In both studies, the benefits lasted for weeks after subjects stopped taking chondroitin sulfate.* In another controlled study, 192 subjects took chondroitin sulfate or a placebo daily for one year. At the end of the trial, chondroitin sulfate maintained healthy joint cartilage thickness, while those on placebo had decreased cartilage. Improvements in joint function also occurred. The researchers reported that chondroitin exerted a clear chondroprotective effect.* Collagen Type II
A number of studies have also been conducted on the administration of collagen type II to individuals that have various joint issues. Much of this research has been conducted on animal models of joint conditions, while there are also studies showing the effectiveness of oral collagen type II preparations in humans for maintenance of healthy joints.* A randomized, controlled trial conducted on 60 patients with joint health issues in 1993 found that oral administration of chicken collagen type II for 3 months led to a significant decrease in swollen and tender joints in this group, as compared to no measurable improvement in the placebo group. There were also no side effects seen with the treatment. A second multicenter, double-blind, placebo-controlled trial in 274 individuals with joint issues was published in 1998. The participants were given collagen type II orally for 24 weeks. Positive effects of the treatment were noted while no adverse effects were seen.* A paper published in 2000 reviewed the literature to assess the role of hydrolyzed collagen in joint and bone health. It was found that hydrolyzed collagen, when administered orally, was able to support joint health in most of the trials reviewed, while the author concluded that, “Its high level of safety makes it attractive as an agent for long-term use.”* Hyaluronic Acid (HA)
Most of the literature on hyaluronic acid and joint health deals with its intra-articular use, or injections of HA directly into the joints. In this realm, there is good evidence for the effects of HA on joint function.* A study was conducted with injectable HA in individuals with TMJ (temporomandibular joint) conditions. Participants received two injections, each one week apart, or placebo injections with saline. In the HA group, the researchers found decreased clicking sounds and increased function of the joint at 1 month (90% of patients showed improvement) and 6 months (63%) of follow-up, compared to about 26% of the placebo group showing improvement at 6 months.* A pair of researchers also conducted a literature review of the trials using HA for improving joint health that was published in 2005. Their findings indicate a positive role for HA in modifying the structure of the joint and slowing progressive deterioration of joint function and mobility. Hyaluronic acid seems to have a natural affinity for joint tissue, and is therefore able to help support healthy joint structure and function.* Maintains Youthful Skin
Hyaluronic Acid and Collagen are both vital components of skin tissue. Both compounds are known to decline with aging. Collagen is a vital structural component of the skin. It is also one of the most important substances required for proper skin barrier function and health. Collagen, as a major component of the connective tissue, provides structural support, increasing elasticity and tone of the skin.* In 1994, researchers performed comparative measurements of hyaluronic acid levels in the skin of young and elderly individuals. The researchers had hypothesized that a major reason for the aged appearance of skin in the elderly is a reduction of hyaluronic acid levels. What they found using their methods is that there is a progressive reduction in the number of hyaluronic acid granules in human skin with age, until a complete absence of these granules was seen in individuals 60 years or older. These variations in HA levels with age could, according to the researchers, account for the decreased turgidity, wrinkled appearance and altered elasticity of skin tissue. Further research was needed to determine the effect of exogenously administered HA on the suppleness of human skin.* In a laboratory study conducted in 1998, researchers analyzed the effects of HA given to live human skin cells. Whereas the cells on their own had a low rate of renewal, hyaluronic acid added to the cells resulted in increased proliferation of skin cells in the collagen matrix. This showed that supplementing skin cells with HA caused a significant increase in the ability of cells to go through the cell cycle. One of the major benefits of this may be hyaluronic acid’s ability to continually renew skin tissue to help maintain a youthful appearance of the skin.*
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Supplement FactsServing Size: Two (2) Capsules
Servings Per Container: 30 | | | | Amount
Per Serving | Daily
Value | BioCell Collagen II
providing: | 1,000 mg | ** | | Hyaluronic Acid | 100 mg | ** | Chondroitin
(Sulfate) | 200 mg | ** | Hydrolyzed Collagen
(Type II) | 600 mg | ** | | | US patents 6,025,327; 6,323,319; & 6,780,841 |
** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet. |
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| Gelatin Capsule, Magnesium Stearate (Vegetable Source), Rice Powder |
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| As a dietary supplement, two (2) capsules daily with eight to ten (8-10) ounces of water, with or without food, or more as directed by a health care practitioner. |
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| If pregnant or nursing, consult your healthcare provider before taking this or any other supplement. ... Keep out of reach of children. ... Store in a cool, dry place. |
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| Doctors Best products do not contain milk, egg, wheat, yeast, corn, sugar, sweeteners, starch, salt, preservatives, waxes, coating or colors. Doctor's Best products are also GLUTEN FREE. |
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| Aging, Joint Comfort, Joint Health, Joint Mobility, Joint Pain, Skin Conditions, Swollen Ankles, Swollen Joints |
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| Ankle, Dermis, Elbow, Epidermis, Finger, Hip, Joints, Knee, Skin, Toes, Wrist |
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We firmly believe that the integration of scientific research and traditional wisdom is how nutritional and herbal supplements will reach their exciting potential. Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Careful research and precise formula development keeps us at the leading edge of quality, effectiveness, and innovation. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Countless hours have been spent analyzing scientific literature to provide sound alternatives to the proliferation of questionable supplements in the marketplace. Each Doctor's Best product is accompanied by an annotated "Fact Sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with the FDA in accordance with DSHEA regulations. Traditional wisdom, up-to-date research, product quality you can trust: everything you need to develop smart strategies for achieving optimal health and well-being. We think you’ll agree that this combination of products and services is second to none. |
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Q. What are your capsules made of?
A. Doctor's Best capsules are typical gelatin capsules, with the exception of select products now available in veggie cap form. They are made of gelatin from cattle, like the familiar "Knox gelatin" sold in grocery stores.
The gelatin used to make Doctor's Best's capsules is manufactured in accordance with strict guidelines that ensure it is BSE-free. The FDA and the supplement industry approved these guidelines. The gelatin is made only from cattle living in non-BSE countries. All Doctor's Best capsules are in full compliance with the FDA's September 1997 industry guide, The Sourcing and Processing of Gelatin to Reduce the Potential Risk Posed by Bovine Spongiform Encephalopathy in FDA-Regulated Products for Human Use.
Q. How long does it take for a capsule to dissolve?
A. Approximately 30-45 minutes. For 2-piece gelatin capsule, the USP standard for maximum dissolution time is 45 minutes.
Q. How long does it take for a tablet to dissolve?
A. FDA Rules & Regulations require tablets to dissolve in 45 minutes or less. However, Doctor's Best sets its standards higher. They require that their tablets dissolve in 30 minutes or less. Every lot of products in tablet form is tested to verify that it dissolves in under 30 minutes.
Q. Can I find out how fast a capsule or tablet dissolves by dropping it in a glass of water or vinegar at home?
A. Testing dissolution times at home using vinegar is not an accurate way to learn what happens to capsules and tablets in your stomach. Because stomach acid is much stronger than vinegar, capsules and tablets dissolve much faster in the stomach than in a glass of water or vinegar. Also, the stomach continually "agitates" its contents, much like a washing machine does. |
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Q. Who determines what the daily dosage should be? And how is this done?
A. A panel of scientists at The Natural Academy of Sciences performs extensive research, ongoing clinical studies and scientific testing in order to determine the RDI (Recommended Daily Intake).
Q. I see that Silicon Dioxide has been used as an excipient in some of your products. Should I be concerned?
A. Silicon Dioxide is a GRAS (Generally Recognized As Safe) food additive. Numerous studies have found the following:
The oral toxicity for humans would be greater than 350 grams in one dose based on allometric comparisons between the mice studied and humans.
A single dose of 2,500mg of amorphous polymeric silicon dioxide to human volunteers did not significantly raise the SiO2 excretion in the urine. This suggests poor absorption of silicon dioxide (Langendorf 1966).
Less than one one-hundredth (1/100th) of the dose was found in urine, suggesting extremely poor absorption (Langendorf 1966).
This would suggest that there is no scientific reason to eliminate silicon dioxide as an excipient at the very low levels found in dietary supplements.
Q. Why is silicon dioxide used as an excipient in Doctor’s Best products? Why are excipients used at all?
A. Silicon Dioxide is used as a flow agent to enable "sticky" substances to flow through the encapsulation equipment. If silicon dioxide were not used, other flow agents would have to be used which would actually increase the number of excipients found in a given product. Ideally, the fewer excipients used, the better.
Q. Is there a limit to how many vitamins can be taken safely in one day?
A. Our bodies need vitamins and minerals, and if taken in large amounts, vitamins and minerals can adversely affect health. Large amounts of anything can be toxic. Our best advice is to work with a nutritionally aware doctor and follow label directions. |
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1. Morreale P, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol (1996) 23:1385-91.
2. Mazières B, et al. Chondroitin sulfate for the treatment of coxarthrosis and gonarthrosis. A prospective, multicenter, placebo-controlled, double blind trial with five months follow up. Rev. Rhum. Mal. Ostèoartic. 1992;59(7-8):466-472.
3. Pipitone V, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate versus placebo in patients with femorotibial gonarthritis. Current Therapeutic Research 1992 52(4):608-38.
4. Trentham DE, et al. Effects of oral administration of type II collagen on rheumatoid arthritis. Science. 1993 Sep 24; 261(5129) 1727-30.
5. Barnett ML, et al. Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 1998 Feb; 41(2): 290-7.
6. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000 Oct;30(2):87-99.
7. Hepguler S, et al. The efficacy of intra-articular sodium hyaluronate in patients with reducing displaced disc of the temporomandibular joint. J Oral Rehab. 2002; 29: 80-86.
8. Goldberg VM, Buckwalter JA. Hyaluronans in the treatment of osteoarthritis of the knee: evidence for disease-modifying activity. Osteoarthritis Cartilage. 2005 Mar;13(3):216-24
9. Ghersetich I, et al. Hyaluronic acid in cutaneous intrinsic aging. Int J Dermatol. 1994 Feb; 33(2): 119-22.
10. Greco RM, et al. Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix. J Cell Physiol. 1998 Dec; 177(3): 465-73. |
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Our Price: $11.43
Retail Price: $19.99
You Save: $8.56 each, a 43% Savings! |
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