Supplement Facts

Coenzyme Q10 is a vitamin-like nutrient found in the human body. Essential to life, CoQ10 works at the cellular level to produce metabolic energy in the form of ATP.*1,2 CoQ10 serves as a vital link in the “electron transport chain,” which is the final step in the production of ATP inside cells. Lacking adequate CoQ10, cells become energy-deficient. When cells are nourished with optimal levels of CoQ10, tissues, organs and systems function optimally.

Strengthens and Protects the Heart*

The heart is the hardest-working muscle in the body. Because of its high energy requirements, the heart needs to be well supplied with CoQ10 at all times. The body’s highest concentration of CoQ10 occurs in heart muscle tissue. (Heart muscle cells contain large numbers of mitochondria.) Numerous clinical studies have demonstrated significant improvements in heart function with oral administration of CoQ10.3,4,5

Supports Immune Function*

When the immune system goes into battle for us, immune cells need large amounts of energy to carry out their defensive functions. CoQ10 is required for this energy to be available. Experimental research on animals has shown that CoQ10 enhances immune functions such as the activity of phagocytes, and antibody production.* Age-related immune suppression has been observed in mice given CoQ10.6

Antioxidant Protection

CoQ10 is a versatile antioxidant.* The reduced form of CoQ10, ubiquinol-10, has been found to protect LDL against peroxidation by free radicals more effectively than vitamin E.* CoQ10 stabilizes membranes,* thus protecting them from free-radical damage.7,8,9

Benefits the Gums*

A number of studies have shown that CoQ10 supports repair of gingival (gum) tissue. Gingival tissues in people with periodontal disease have been found deficient in CoQ10. In several double-blind clinical trials, oral administration of CoQ10 has resulted in significant improvements.10,11

Many Clinical Benefits

Research studies and clinical reports suggest CoQ10 has a broad range of applications stemming from its ability to support the heart and cardiovascular system, the immune system, cellular energy production, liver function, nerves, and muscles.*

CoQ10 — Vitamin E’s Partner

In vitro studies suggest CoQ10 in combination with vitamin E protects LDL cholesterol from oxidation more effectively than vitamin E alone. Protecting LDL from being oxidized by free radicals is now thought to be important for cardiovascular health.9,12

Bioperine® — A Bioavailability-Enhancing Phytonutrient

Bioperine® is a natural extract derived from black pepper that enhances nutrient absorption.* Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. In a recent study (publication pending), the administration of 5 mg of Bioperine® together with 120 mg of CoQ10 per day resulted in a 32% increase in CoQ10 absorption after 21 days.13 (This is especially important for individuals who have impaired absorption of fat-soluble nutrients such as CoQ10.)

1. Folkers, K., Wolaniuk, A., Progress in biomedical and clinical research on coenzyme Q10. Drugs Exptl. Clin. Res. 1984; X(7):513-517.
2. Lenaz, G., et. al., “The essentially of coenzyme Q for bioenergetics and clinical medicine.” Drugs Exptl. Clin. Res. 1985; XI(8):547-556.
3. Morisco, C., Trimarco, B., Condorelli, M., “Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study.” Clin. Investig. 1993; 71:S134-S136.
4. Mortensen, S.A., Vadhanavikit, S., Muratsu, K., Folkers, K., “Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure.” Int. J. Tiss Reac. 1990; XII(3):155-62.
5. Poggesi, L., et. al., Effect of coenzyme Q10 on left ventricular function in patients with dilative cardiomyopathy. Current Therapeutic Research 1991; 49(5):878-886.
6. Folkers, K., Wolaniuk, A., “Research on coenzyme Q10 in clinical medicine and in immunomodulation.” Drugs Exptl. Clin. Res. 1985; XI(8):539-545.
7. Littarru, G.P., et. al., “In vitro effect of different ubiquinones on the scavenging of biologically generated O2.” Drugs Exptl. Clin. Res. 1985; XI(8):529-532.
8. Littarru, G.P. Lippa, S., “Coenzyme Q and antioxidant activity: facts and perspectives.” Drugs Exptl. Clin. Res. 1984; X(7):491-96.
9. Stocker, R., Bowry, V.W., Frei, B., “Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.” Proc. Natl. Acad. Sci. 1991; 88:1646-1650.
10. Hansen, I., Iwamoto, Y., Kishi, T., Folkers, K., “Bioenergetics in clinical medicine. IX. Gingival and leucocyte deficiencies of coenzyme Q10 in patients with periodontal disease.” Research Communications in Chemical Pathology and Pharmacology 1976; 14:729-738.
11. Wilkinson, E. Arnold, R., Folkers, K., “Treatment of Periodontal and Other Soft Tissue Diseases of the Oral Cavity with Coenzyme Q” (in) Biomedical and Clinical Aspects of Coenzyme Q 1977; 1:251-266. K. Folkers and Y. Yamaura, eds., Elsevier Science Publishing Co., N.Y.
12. Thomas, S., Neuzil, J., Stocker, R., “Cosupplementation with coenzyme Q prevents the prooxidant effect of alpha-tocopherol and increases the resistance of LDL to transition metal dependant oxidation initiation.” Arteriosclerosis, Thrombosis and Vascular Biology 1996; 16(5):687-96.
13. Badmaev, V., Majeed, M., “Comparison of Coenzyme Q10 (CoQ10) bioavailability when ingested alone and in combination with Bioperine®.” Sabinsa Corporation Research Report. 1996 (unpublished).