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Glucoset
by Douglas Labs
60 Vegetarian Capsules
Nutritional Support For Healthy Glucose Metabolism*
| Our Price: $26.30 | 
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Glucoset capsules, provided by Douglas Laboratories, contain a complementary blend of thiamin, biotin, chromium, alpha-lipoic acid, N-acetyl-L-cysteine, and standardized extract of Gymnema sylvestre leaf for targeted nutritional support of glucose metabolism.*
FUNCTIONS
Glycation is the non-enzymatic attachment of sugars to major molecules in the body, including proteins, lipids, and nucleic acids. Glycation reactions generate advanced glycation end-products (AGE’s) and glycotoxin intermediates. AGE’s can cause abnormal and destructive functioning of body proteins, lipids, and nucleic acids. AGE associated damage is suspected in the pathogenesis of many diseases and age-related deteriorations. AGE’s can be created endogenously, often as a consequence of excessive blood glucose levels. AGE’s are also present in browned foods and cured tobacco. As uncontrolled blood glucose levels give rise to the formation of dangerous AGE’s, it is crucial to maintain blood glucose levels within normal, healthy limits to avoid excessive AGE induced damage.*
Maintenance of normal blood glucose levels is fundamental to preventing AGE formation. Chromium is an integral component of the glucose tolerance factor (GTF), a naturally occurring compound of chromium, nicotinic acid, and amino acids that is essential for proper glucose metabolism. Adequate chromium nutrition is essential for the formation of GTF and subsequent healthy metabolism of normal blood glucose levels.*
Biotin serves as a cofactor of glucose metabolism and induces glucokinase, an enzyme that encourages cells to retain glucose for energy production rather than release it into the blood stream. Alpha-lipoic acid appears to enhance glucose use by muscles by augmenting muscle protein content. Gymnema sylvestre is an Ayurvedic botanical that may assist in the normal regeneration and repair of healthy pancreatic beta cells. Gymnema may also support healthy intestinal glucose absorption.*
Select nutrients help directly arrest glycation reactions. A derivative of thiamin (vitamin B1), called thiamin pyrophosphate, and alpha-lipoic acid have both been shown to prevent in vitro AGE production. Also crucial to controlling AGE formation and subsequent damage is antioxidant protection. Oxidative stress is closely related to AGE production and is a known contributing factor to many of the same health concerns thought to be associated with AGE damage. In vitro studies of N-acetyl-L-cysteine have documented inhibition of glycation induced damage to pancreatic cells. N-acetyl-L-cysteine is a potent antioxidant, serving as an intracellular precursor of glutathione.*
INDICATIONS
Glucoset may be a useful dietary supplement for those who wish to support nutritional control of healthy blood sugar metabolism.*
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Supplement FactsServing Size: Two (2) Vegetarian Capsules
Servings Per Container: 30 | | | | Amount
Per Serving | Daily
Value | Thiamine
(Pyrophosphate) | 50 mg | 3,333% | | Biotin | 2,500 mcg | 833% | Chromium
(ChromeMate Polynicotinate***) | 800 mcg | 667% | | | Alpha Lipoic Acid | 200 mg | ** | N-Acetyl Cysteine
(USP) | 500 mg | ** | Gymnema
sylvestre leaf, dried extract, minimum 25 percent gymnemic acids | 400 mg | ** | | | ***ChromeMate brand. U.S. Patent Number 4,923,855 InterHealth Co.****Lipoic Acid used in this product is of the highest quality available and of Italian origin. |
** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet. |
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| Cellulose, Stearates (Vegetable Source) |
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| As a dietary supplement, two (2) capsules daily, or more as directed by healthcare professional. |
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| Keep out of the reach of children. ... Store in a cool, dry place. ... Do not use if outer seal is missing. |
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| This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring. |
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| Blood Sugar Balance, Blood Sugar Fluctuations, Glucose Metabolism |
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| Blood, Glucose |
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Anderson RA. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr 1997;16:404-10.
Anderson, RA. Chromium, glucose intolerance, and diabetes. J Am Coll Nutr 1998;17:548-55.
Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. J Ethnopharmacol 1990;30:295-300.
Bierhaus A, Chevion S, Chevion M, Hofmann M, et al. Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes 1997;46:1481-90.
Booth AA, Khalifah RG, Hudson BG. Thiamine pyrophosphate and pyridoxine inhibit the formation of antigenic advanced glycation end-products: comparison with aminoguanidine. Biochem Biophys Res Commun 1996;220:113-9.
Chauhan J, Dakshinamurti K. Transcriptional regulation of the glucokinase gene by biotin in starved rats. J Biol Chem 1991;266:10035-8.
Cunningham JJ. Micronutrients as nutriceutical interventions in diabetes mellitus. J Am Coll Nutr 1998;17:7-10.
De Mattia G, Bravi MC, Laurenti O,Cassone-Faldetta M, et al. Reduction of oxidative stress by oral N-acetyl-L-cysteine treatment decreases plasma soluble vascular cell adhesion molecule-1 concentrations in non-obese, non-dyslipidaemic, normotensive, patients with non-insulin dependent diabetes. Diabetoliga 1998;41:1392-6.
Frye EB, Degenhardt TP, Thorpe SR, Baynes JW. Role of the Maillard reaction in aging of tissue proteins. Advanced glycation end product-dependent increase in imidazolium cross-links in human lens proteins. J Biol Chem 1998;273:18714-9.
Kaneto H, Fujii J, Myint T, et al. Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction. Biochem J 1996;320:855-63.
Koutisikos D, Agroyannis B, Tzanatos-Exarchou H. Biotin for diabetic peripheral neuropathy. Biomed Pharmacother 1990;44:511-4.
Levi B, Werman MJ. Long-term fructose consumption accelerates glycation and several age-related variables in male rats. J Nutr 1998;128:1442-9.
Low PA, Nickander KK, Tritschler HJ. The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy. Diabetes 1997;46 Suppl 2:S38-42.
Mertz W. Chromium in human nutrition: a review. J Nutr 1993;123:626-33.
Obrosova I, Cao X, Greene DA, Stevens MJ. Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: effect of DL-alpha-lipoic acid. Diabetologia 1998;41:1442-50.
Okabayashi Y, Tani S, Fujisawa T, et al. Effect of Gymnema sylvestre, R.Br. on glucose homeostasis in rats. Diabetes Res Clin Pract 1990;9:143-8.
Preuss HG. Effects of glucose/insulin pertubations on aging and chronic disorders of aging: the evidence. J Am Coll Nutr 1997;16:397-403.
Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94.
Shanmugasundaram KR, Panneerselvam C, Samundram P, Shanmugasundaram ER. Enzyme changes and glucose utilization in diabetic rabbits: the effect of Gymnema sylvestre, R. Br. J Ethnopharmacol 1983;7:205-34.
Thorpe SR, Baynes JW. Role of the Maillard reaction in diabetes mellitus and diseases of aging. Drugs Aging 1996;9:69-77.
Yang CW, Vlassara H, Peten EP, et al. Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease. Proc Natl Acad Sci USA 1994;91:9436-40.
Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid. A 3-week multicentre randomised controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33. |
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Our Price: $26.30 |
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