Glucosamine Sulfate & MSM by NOW Foods - Joint And Immune Enhancers 60 Capsules Provides Support For Healthy Joint Structures* Our Price: $9.10 Retail Price: $15.73 You Save: $6.63 each, a 42% Savings!
Glucosamine and MSM combine the nutritive benefits of two potent dietary supplements. Glucasmine is an amino sugar derived from the chitin of shellfish that is used by the body to support healthy joint structures.* MSM is a natural form of organic sulfur found in all living organisms and is currently a popular supplement with health enthuasists everywhere.
Additional Sizes Available
180 Capsules - 1.1 g of Glucosamine
60 Capsules - 1.1 g of Glucosamine
Supplement Facts
Two (2) Capsules Contain:
Amount Per Serving
Potassium(potassium chloride) 245 mg Glucosamine(glucosamine sulfate) (from 1,500 mg Glucosamine Potassium Sulfate Complex) 1.1 g MSM (Methylsulfonylmethane) 500 mg Chondroitin(Sodium Sulfate) (from Bovine Cartilage) 50 mg
Stearic Acid (Vegetable Source), Magnesium Stearate (vegetable source), Gelatin Capsule, Contains SHELLFISH derivative. Contains no sugar, salt, starch, yeast, wheat, gluten, corn, soy, milk, egg or preservatives. As a dietary supplement, two (2) capsules, one to two times (1-2x) daily with meals or on an empty stomach, or as directed by a healthcare practitioner. Persons with a known allergy to shellfish should not use this product. Connective Tissue Support , Joint Support Dislocated Joint , Joint Pain , Knee Issues Connective Tissue , Joints , Low Back Absorbed , Discomfort , Pain What is glucosamine?
Glucosamine is composed of glucose and glutamine (an amino acid). It is utilized by chondrocytes to form glycosaminoglycans (GSG’s) and proteoglycans. Both of these constituents attract and bind water into cartilage, increasing resiliency.
How is glucosamine manufactured?
Glucosamine is supplied mostly by China. The shells of shrimp and crabs have their proteins and minerals removed producing Chitin or poly N-acetylglucosamine. Manufacturers use acid with a depolymerizing and deacetylating process to produce glucosamine hydrochloride or glucosamine sulfate.
By Joseph Zhou, Ph.D., NOW Foods’ Director of Laboratory Methods and Scientific Support, July 27, 2005
The AOAC Methods Committee on Dietary Supplements in April voted unanimously to approve NOW Foods’ method, Determination of Glucosamine in Raw Materials and Dietary Supplements Containing Glucosamine Sulfate and/or Glucosamine Hydrochloride by HPLC with FMOC-Su Derivatization, as an AOAC First Action Official Method SM .1 This method has been designated as AOAC method 2005.01, and will be published in the July/August 2005 issue of the Journal of AOAC INTERNATIONAL.
AOAC INTERNATIONAL is a 120 year-old not-for-profit scientific association committed to worldwide confidence in analytical testing results. The organization was formerly known as the Association of Official Analytical Chemists . The AOAC Official Method Program is the result of a contract between the Center for Food Safety and Applied Nutrition, the FDA and the Office of Dietary Supplements, part of the National Institutes of Health, with AOAC INTERNATIONAL. The purpose of the contract is to provide the FDA, other government agencies, and the dietary supplements industry with AOAC Official Methods suitable for testing both raw materials and commercially available dietary supplements.
In April 2003, AOAC’s Expert Review Panel (ERP) on glucosamine selected NOW’s glucosamine method as the best method for further laboratory validation. Since then, the method has successfully completed AOAC’s rigorous validation process, which includes both single laboratory validation and collaborative study. Twelve validation laboratories worldwide, ten in the United States, one in Canada and one in Germany, participated in the collaborative study. The method is simple, robust and accurate.2,3
Five types of test materials were included in the collaborative study: (1) tablets, (2) capsules, (3) drink mix powders, (4) raw materials, and (5) liquid products. The materials selected included glucosamine from shellfish and vegetarian sources, in both the hydrochloride and sulfate salt forms, as well as glucosamine in combination with other ingredients commonly found to co-occur in dietary supplement formulas - including MSM, SAMe, chondroitin sulfates and Vitamin C - at levels commonly found in commercially available products. It is believed that the method may easily be extended to products not covered by the collaborative study through AOAC’s new mechanism for matrix extension of its Official Methods SM . None of the results from the collaborating laboratories was an “outlier” (test results out of the expected range), indicating the robustness and accuracy of the method.
We first developed this glucosamine method in the NOW lab five years ago and have been using the same method for our quality control of glucosamine products ever since then. This is now becoming the only internationally accepted standard method for testing glucosamine products. NOW’s accomplishment in developing this glucosamine method evidences our high standards in quality testing to assure product quality, as well as providing a significant contribution to an industry advancement of scientific methods. We employ one of the finest teams of product quality experts in the supplement industry and conduct specialized tests, analyses and inspections that allow our company to offer superior products to our customers.
References:
The AOAC INTERNATIONAL publication, Inside Laboratory Management, July/August 2005, Page 5
J. Zhou, T. Waszkuc, F. Mohammed. Single Laboratory Validation of a Method for Determination of Glucosamine in Raw Materials and Dietary Supplements Containing Glucosamine Sulfate and/or Glucosamine Hydrochloride by High Performance Liquid Chromatography with FMOC-Su Derivatization. Journal of AOAC INTERNATIONAL, Vol. 87, No. 5, 2004, Pages 1083-1092
J. Zhou, T. Waszkuc, F. Mohammed, C. Ray, R. Buren, W. Wang, H.Nguyen, J. Jabusch, D. Sullivan, X. Kou, Q. Yang, A. Solyom, J. Wang, T. Peng, Q. Zheng, M. Blumhorst, M. Nagarajan, B. Podhola, L. Huang, C. Shevchuk, R. Das, K. Orellana, K. Reif. Determination of Glucosamine in Raw Materials and Dietary Supplements Containing Glucosamine Sulfate and/or Glucosamine Hydrochloride by High Performance Liquid Chromatography with FMOC-Su Derivatization: Collaborative Study. Will be published in Journal of AOAC INTERNATIONAL, July/August, 2005
Everyone old enough to walk appreciates the value of flexibility and ease of movement. Unfortunately many of us take such good things for granted. A famous folksinger sang, "You don't know what you've got till it's gone." That's certainly true for millions Americans who live with stiff and uncomfortable joints.
Fortunately there are a number of nutrients available that provide the vital components of healthy joint structure and function and ease of mobility. These nutrients are referred to as “chondroprotective agents,” and include glucosamine and chondroitin, which supply the raw material necessary to produce new cartilage, and may even help rebuild worn cartilage. Other chondroprotective nutrients and herbs, like Cetyl Myristoleate, MSM, and Boswellin, work synergistically with glucosamine and chondroitin and further support normal joint function.
To understand how chondroprotective agents work, one must first understand how joints work. The key element in human joints is articular cartilage, the shock-absorbing tissue that connects two bones together and allows pain-free movement. Articular cartilage is comprised of two different molecules, collagen and proteoglycans, with the remainder composed primarily of water (65-85%). Collagen, a protein that binds tissue together, provides elasticity. Proteoglycans, composed of sugars and protein, absorb water, which provides lubrication and resiliency, nature's shock absorber for your joints. Both compounds are produced by chondrocytes, caretaker cells responsible for the formation and maintenance of cartilage. A deficiency in any one of the above constituents will increase the likelihood of wear and tear on articular cartilage, which can eventually lead to compromised joint function. Glucosamine and chondroitin are safe, natural and effective nutrients that support healthy joint function by supplying the materials needed to produce collagen and proteoglycans.
GLUCOSAMINE
Glucosamine is composed of glucose (a sugar) and glutamine (an amino acid). It is utilized by chondrocytes to form glycosaminoglycans (GSG) and proteoglycans (PG). Both of these constituents attract and bind water into cartilage, increasing resiliency. Research indicates that glucosamine may actually help your body repair damaged or eroded cartilage. A number of studies have been conducted on glucosamine sulfate and glucosamine hydrochloride, with a preponderance of positive results. Glucosamine sulfate is considered the more effective of the two. One study from the University of Liege in Liege, Belgium studied the effects of glucosamine sulfate on 212 patients with knee osteoarthritis. Participants took either 1,500 mg glucosamine or a placebo once daily for three years. The study compared joint-space width at enrollment, one year, and at the study’s conclusion. The 106 patients on placebo had a progressive joint-space narrowing, while participants taking glucosamine experienced no significant joint-space loss, indicating glucosamine may beneficially modify cartilage structure.3 A study published in the journal Osteoarthritis and Cartilage in 1998 investigated the in vitro effects of glucosamine sulfate on proteoglycan and collagen production by chondrocytes taken from osteoarthritic articular cartilage. The results showed “a statistically significant stimulation of PG production by chondrocytes from human osteoarthritic cartilage cultured for up to 12 days in 3-dimensional cultures.” 4 Another study from Italy enrolled eighty inpatients with established OA. They received either 1,500 mg of glucosamine sulfate or placebo daily for 30 days. The patients treated with glucosamine sulfate experienced a reduction in symptoms almost twice as large and twice as fast as those receiving placebo. Researchers also used electron microscopy of patient’s articular cartilage to support this hypothesis. Patients who received glucosamine sulfate showed a picture more similar to healthy cartilage. The researchers concluded that glucosamine sulfate tends to rebuild damaged articular cartilage and restore articular function.5
CHONDROITIN
Chondroitin is classified as a glycosaminoglycan. It bonds with collagen to form the basis of connective tissue. Chondroitin helps attract fluid into proteoglycans, thereby bringing nutrients into cartilage and providing shock absorption. While glucosamine helps manufacture and maintain cartilage, chondroitin keeps cartilage from becoming malnourished. Chondroitin works synergistically with glucosamine, and these two nutrients form the basis of most joint health supplements on the market today. A 6-month randomized, multi-center, double-blind, double-dummy study published in 1996 compared the effectiveness of chondroitin versus a popular non-steroidal anti-inflammatory drug (NSAID) in patients with knee osteoarthritis (OA). One hundred and forty-six patients with knee OA were recruited and separated into two groups; an NSAID group and a chondroitin sulfate (CS) group. The NSAID group was given the NSAID and a placebo for the first month, then placebo alone for months 2-3. The CS group was given the NSAID and CS for the first month, and then CS alone for months 2-3. Both groups were then given 1200mg of CS for months 4-6. “Patients treated with the NSAID showed prompt and plain reduction of clinical symptoms, which, however, reappeared after the end of treatment; in the CS group, the therapeutic response appeared later in time but lasted for up to 3 months after the end of treatment. CS seems to have slow but gradually increasing clinical activity in OA; these benefits last for a long period after the end of treatment.” 6
NOW® Foods is your source for natural joint support products. Our Extra Strength Glucosamine & Chondroitin is one of our best-selling products, and we also have combination supplements that include MSM, Concentrace® minerals, and more. We also carry both glucosamine and chondroitin as separate products, as well as in powder and lotion forms.
References:
Balch, James F. et. al. ; Prescription For Nutritional Healing 3rd Edition ; Avery; Penguin Putnam; 2000
Benedikt, H.; Glycosaminoglycans And Derivatives For Treatment Of Arthritis ; Chiropractic Products, May 1997, pp. 92-95
Reginster, Jean Yves et. al.; Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial ; The Lancet, 2001, Vol. 357, No. 9252
Bassleer, C. et. al.; Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro ; Osteoarthritis and Cartilage, 1998, 6, 427-434
Drovanti, A. et. al.; Therapeutic Activity of Oral Glucosamine Sulfate in Osteoarthritis : A Placebo-Controlled, Double-Blind Investigation; Clinical Therapeutics, Vol. 3, No. 4, 1980, pp. 260-272
Morreale, P. et. al.; Comparison of the Antiinflammatory Efficacy of Chondroitin Sulfate and Diclofenac Sodium in Patients with Knee Osteoarthritis ; Journal of Rheumatology, 1996, 23:8, pp. 1385-1391
Raw Materials
Superior supplements begin with superior raw materials. As the foundation that supports our line of quality products, NOW tests raw materials for contaminants, heavy metals, pesticides and fillers. Our philosophy remains unfaltering; we always start with the purest, freshest raw materials to ensure that the finished product is the best it can be. By partnering with some of the most trusted names in the industry including Lonza, PL Thomas, Cyanotech, Inter-Health, Hoffman LaRoche, Sabinsa and others, NOW is proud to provide unadulterated natural products that are safe, potent and true to their claim.
Natural Ingredients
Mad Cow Free
Growth Hormone Free
Exacting Heavy Metal and Pesticide Specifications
Pure, Fresh Raw Materials, Always
Good Manufacturing Practices
NOW's commitment to Good Manufacturing Practice (GMP) is evident in everything we do. As one of the first companies to receive GMP certification from the NNFA, in addition to being one of the very few to maintain a consistent 'A' rating, we've remained steadfast in our commitment to good manufacturing practices. Our clean, controlled and technologically advanced production facility is regularly inspected by the Food and Drug Administration, and has been certified organic by Quality Assurance International.
Longstanding NNFA GMP "A" Rating FDA Inspected Organic Certification by QAI Clean, Modern, Controlled Production Facility
NOW’s Glucosamine, Chondroitin, and MSM Products are “Simply the Best” More Chondroitin Sulfate Information
Our Price: $9.10 Retail Price: $15.73 You Save: $6.63 each, a 42% Savings!
