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Enzymatic Therapy

Fiber Fusion
by Enzymatic Therapy
120 UltraCaps

Daily Cleansing Fiber In Capsule Form*

Our Price: $7.48
Retail Price: $11.50
You Save: $4.02 each, a 35% Savings!

Fiber Fusion eliminates toxins and supports regularity and cleansing. It's essential that your body receives an ample amount of fiber, every day. Fiber Fusion provides an additional, reliable source.*

As our bodies absorb environmental toxins from the air, water and our food, they can accumulate and wreak havoc on our insides. Fiber helps move the toxins out. Not just for cleansing, Fiber Fusion supports the body's ability to safely absorb and eliminate toxins, promotes regularity, and improves colon health on a daily basis.*

Benefits
• Features True Dispersion technology*
• Clay-free formula

Detoxification products containing clay can deplete the body of healthy minerals, and often contain high levels of lead and other toxins. Since Fiber Fusion is clay-free, you can rely on it every day!*

How Does It Work?

Detoxification and fiber
The removal and excretion of intestinal toxins in detoxification is dependent on supplemental dietary fiber. Only fibers that can effectively bind toxins will be successful in eliminating these harmful substances. Due to the unique benefits of individual fibers, the best binding, removal, and elimination effects are noted when combining different fiber types. Fiber Fusion contains a proprietary blend of fibers with clinically validated effectiveness.

Dietary fibers are complex mixtures of cellulose, hemicellulose, pectin, mucilage, and gums, which are resistant to digestive fluids or enzymes. Fiber promotes laxation and modulates gastric and intestinal physiology. Intestinal flora that normally reside within the colon utilize fiber as a medium for microbial fermentation, resulting in the synthesis of the vitamins, vitamin K and biotin, and the formation of SCFA. The SCFA are absorbed by the colon mucosa to increase fecal matter bulk and to be used as energy.Fiber has been demonstrated in numerous clinical studies to provide support of gastrointestinal, cardiovascular, immune, and endocrine function health.

Unlike many detoxification fiber products, Fiber Fusion does not contain clay. Research has shown that clay can deplete the body of healthy minerals and may contain high levels of lead and other toxins. The all-natural fibers in Fiber Fusion support the body's natural detoxification process without depleting beneficial nutrients.

Psyllium husk
Psyllium husk is a rich source of concentrated soluble fiber that supports healthy intestinal function. Often used in laxation, psyllium husk provides intestinal lubrication for ease in elimination.15 In studies, psyllium husk has been shown to absorb up to fourteen times its weight in water and has more reabsorption ability than any other bowel-supporting fiber. Psyllium husk also supports healthy serum lipid levels that are within normal limits, healthy blood sugar metabolism, healthy blood pressure, healthy immune function, and intestinal microflora health.

Oat bran
The most soluble fiber of any grain, oat bran forms a bulky gel in the intestine, which regulates the flow of excretory matter through the digestive tract. Research has demonstrated that oat bran supports healthy bile acid synthesis, prevents free radical damage as an antioxidant, and supports healthy low-density lipoprotein levels that are already within normal levels.

Guar gum, pectin, marshmallow root
Guar gum is a dietary fiber and stabilizer is from the seed of the guar plant. Research has demonstrated that guar gum supports intestinal health and elimination of excretory matter through the colon. Pectin from citrus fruit is a soluble fiber that has been studied for its support of immune health. Marshmallow root has been studied for its support of colon mucosa. These natural fibers have the additional benefit of mucilaginous properties, supporting intestinal wall health and facilitating the ease of elimination.

Conclusion
As part of a gentle and effective detoxification program, Fiber Fusion aids in the binding and excretion of harmful toxins. The blend of all-natural fiber sources in Fiber Fusion supports healthy intestinal function, promotes healthy bowel elimination, supports healthy bile synthesis, healthy serum cholesterol levels that are already within normal limits, and healthy immune function. Fiber Fusion'sTrue Dispersion technology ensures the fiber is completely released and dispersed throughout the colon for thorough cleansing.

Supplement Facts Serving Size: Four (4) UltraCaps Servings Per Container: 30

	Amount Per Serving	Daily Value
Calories	10
Total Carbohydrate	2g	<1%
Dietary Fiber	2g	8%

Fiber (Proprietary Fiber Blend) psyllium (Plantago ovata) husk, oat (Avena sativa) bran, guar gum (Cyamopsis tetragonoloba) seed extract, pectin (from citrus fruit), and marshmallow (Althaea officinalis) root extract 3.5:1	1,727 mg	**

** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet.

Other Ingredients

Cellulose, Magnesium Stearate, Silicon Dioxide, Vegetable Glycerin, Vegetable Polysaccharide (Capsule)

Suggested Use

As a dietary supplement, four (4) UltraCaps daily with eight (8) ounces of water, or more as recommended by your healthcare practitioner. If desired, may be taken as two (2) UltraCaps in the morning and two (2) UltraCaps at night with eight (8) ounces of water. ...

Warnings

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use. ... Keep bottle tightly closed.

Allergen Info

This product contains NO sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial flavoring, preservatives or ingredients of animal origin. All colors used are from natural sources. Color variations are normal.

Applicable Functions

Cardiovascular Health, Digestive Balance, Digestive Comfort, Digestive Inconsistancy, Gastrointestinal Motility, Gastrointestinal Vitality, Immune System Support

Related Structure Groups

Colon, Detoxification, Digestive System, GI Tract, Large Intestine, Small Intestine

About Enzymatic Therapy

Nature Makes it Pure. Science Makes it Work.

Our People
Enzymatic Therapy sparks with an enthusiasm that comes from knowing we're helping create the best supplement products in the nation.

Our team is made of people who are natural explorers; passionate about the healthful ingredients found in nature but committed to finding the most pure and effective combinations backed by rigorous research.

This buzz doesn't just end at the lab door. Everyone here, from our staff of scientists to our crews running the pharmaceutical-grade machinery to our customer service professionals, shares the exuberance of helping improve the health of America one customer at a time.

Our Reputation
Enzymatic Therapy, Inc. is known as the highest quality provider of therapeutic-dosage natural healthcare products and nutritional supplements in the nation. We strive to be the best for your health.

Our Difference
One thing that sets us apart from the others is the way we make our products. Everything, including raw material evaluation, supplier selection, laboratory analysis and manufacturing standards, is set to conform to the FDA's verified Good Manufacturing Practices, known in the industry as "GMPs."

Our Brands

Quick Tips

Good health doesn't have to be complicated. There are plenty of common-sense steps we can all follow to live better, more active, and fuller lives.

Eat right
We hear this so often it almost loses meaning. Eating right should mean adding things to your diet--more veggies, more fruits, more rich-tasting high-fiber breads and grains. However, it doesn't necessarily mean you have to give up chocolate. After all, there's plenty of beneficial flavonoids in those dark chocolate bars, right? You may just not want to eat chocolate at every meal. Instead of swearing off your favorite (but not healthy) meal forever, try just cutting it down to once or twice a month--make it a treat. As you incorporate more healthy, whole foods into your diet, you'll probably find yourself craving them instead of the bad stuff.

Exercise daily
You don't have to run a marathon or lift your neighbor's house. But, you can start parking a little further away at work each day. Begin taking break time walks, especially if the weather is nice. Dust off that bicycle and see if your friends would like to go for a spin. Almost every town has a dedicated group of folks who do some form of fun exercise. Whatever you do, don't overdo it right off the bat, and choose something you really enjoy. After a couple of weeks, your new exercise regimen will become part of your daily routine, as though it had always been that way.

Strength train your brain
Challenge yourself mentally, and not just by trying to keep up at work.Find a class in your off-hours that teaches something you've always been curious about, but has nothing to do with work. Read a book for fun. Start a board game night with your family. Check out those crossword puzzles. Research in recent years shows that learning new skills and interacting with the world keeps our minds younger much longer. You owe it to yourself to turn off the television and fire up some neurons!

Do something for others
Whether you volunteer for a local environmental group, a food pantry, or your church's annual picnic, people generally feel healthier when their focus is outside of themselves.

Drug Nutrient Interactions

Prescription drug listings are not all-inclusive; the drugs listed below are common examples.

Top Drug Categories Interactions
Anti-anxiety
[Buspar^® (buspirone), Ativan^®(lorezepam) - see Benzodiazepines]
Kava - For reasons similar to benzodiazepines, it is recommended to avoid taking kava with buspirone unless otherwise directed by a licensed health care professional.
St. John's Wort, Ginkgo Biloba - Concurrent use of St. John's Wort and buspirone and St. John's Wort and Ginkgo Biloba with buspirone has resulted in mild serotonin syndrome and should be avoided unless directed by a licensed health care professional.
Grapefruit Juice - Concomitant administration of buspirone and grapefruit juice should be avoided as it increased the concentration of buspirone in the blood.
Antibiotics
(General) Vitamin K - The use of cefmetazole sodium has been associated with hypoprothrombinrmia and treated with Vitamin K supplementation.
Antibiotics

(Aminoglycosides, Cephalosporins, Macrolides, Penicillins, Quinolones, Sulfonamides, Tetracyclines) Calcium, Iron, Magnesium, and Zinc - May prevent the absorption of tetracycline, ciproflaxin, and other antibiotics.
Antibiotics

Gentamycin and Penicillians Potassium Chloride - Concomitant administration of gentamycin with potassium chloride may lower the absorption of potassium chloride.
Antibiotics

Extended spectrum Macrolides [Biaxin^®(clarithromycin), Zithromax^®(azithromycin), Erythromycin, and Tetracyclines] Antacids - Antacids containing magnesium and aluminum have been shown to interfere with azithromycin absorption. People can avoid this by taking azithromycin two hours before or after any aluminum or magnesium containing products. Studies show the magnesium typically found in supplements affects absorption of azythromycin.
Anti-Diabetic
[Glucophage^®(metaformin), Actos^®, Avandia^®(pioglitazone)] DHEA(Dehydroepiandrosterone) - Metaformin has been shown to increase levels of DHEA in blood.
Antihistamines

[Claratin^®(loratadine), Allegra^®(fexofenadine)]
St. John's Wort - Concomitant use of St. John's Wort can have an effect on plasma levels of fexofenadine.
Fruit Juices - Co-administration of grapefruit, orange, and apple juices decreases the absorption of fexofenadine.
Anti-Psychotics
[Zyprexa^®(olanzapine), Risperdal^®(risperidone)]
Vitamin B₆ and E - Reported to effectively treat risperidone -related neuroleptic malignant syndrome.
Glycine - Glycine in combination with antiphychotic treatment has shown significant effects on the effectiveness of these drugs. While adjunctive glycine treatment has been shown to improve negative symptoms in combination with clozapine, olanzapine, and risperidone. Additional studies have shown it to be ineffective in combination with clozapine.
Supplementation with glycine in combination with an antipsychotic should only be done under the supervision of a health care professional.
Anti-Seizure

[Tegretol^®(carbamazepine), Dilantin^®(phenytoin), phenobarbital and Mysoline^®(primidone). Depakene^®(valproic acid) and Depakote^®(divalproex) are also anticonvulsant drugs.] Magnesium, Black Pepper, and Caffeine - Concomitant administration of phenytoin (Dilantin^®) or phenobarbital with magnesium oxide may lower magnesium oxide's absorption. Concomitant administration of Dilantin^® and black pepper and/or long pepper may cause the phenytoin to be absorbed more rapidly and eliminated more slowly. Phenytoin also increases the metabolism and loss of caffeine from the body.
Benzodiazepines
Kava - Due to the similarity of effects, it is usually recommended to avoid taking Kava with Benzodiazepines unless otherwise directed by a licensed health care professional.
St. John's Wort - Concomitant administration of St. John's Wort with alprazolam and should be avoided unless otherwise directed by a licensed health care professional.
Beta-Blockers Potassium - Concomitant use of certain Beta-Blockers may increase potassium levels.
Pepper (Piper Nigrum, Piper Longum) - In single dose human study, piperine, a chemical found in black pepper and long pepper, was reported to increase blood levels of propranolol, which could increase the activity and risks of the drug's side effects.
Antacids - One study showed a reduction in absorption of Sotalol(Betapace^®) when taken concomitantly with an aluminum oxide or magnesium hydroxide antacid. This interaction can be avoided by taking the medication two hours apart.
Magnesium - Magnesium has been effectively used to treat heart arrythmias that have resulted from administration of Sotalol(Betapace^®).
Calcium Channel Blockers Calcium - High level calcium supplementation may reverse the blood pressure-lowering actions of some calcium channel blocker drugs.
Vitamin D - Vitamin D may interfere with the effectiveness of verapamil.
St. John's Wort - A recent study showed that St. John's Wort decreased the bioavailability of R- and S-verapamil.
Fruit Juices - Ingestion of grapefruit, grapefruit juice, and grapefruit products has been shown to increase the adverse effects of calcium channel blockers or similar drugs.
Diuretics, Potassium-Sparing

[Amiloride, Aldactone^®(spironolactone), Dytac^®(triamterene)] Magnesium - Magnesium tends to be preserved.
HIV Antivirals St. John's Wort - St. John's Wort has been shown to speed up the elimination of indinavir which may result in resistance to the drug. St. John's Wort should not be taken concomitantly with HIV Antivirals.
Sho-Saiko-To - This herbal medicine has been shown to enhance the antiviral activity of lamivudine.
Carnitine- Depletion of Carnitine levels may be responsible for muscle and nerve damage in patients on Antiviral therapies. Canitine supplementation is recommended.
Antioxidants- A small study showed a positive effect of antioxidant supplementation on hyperlactatemia (elevated levels of lactate in the systemic circulation) in patients on long-term Antiviral therapy.
N-Aceylt Cysteine- Studies have shown supplementation a NAC during Antiviral therapy may reduce AZT toxicity.
Vitamins E and C- Supplementation with Vitamin E has shown to improve the efficacy of AZT and supplementation with Vitamins E and C may reduce AZT-related cellular damage.
NSAIDs (non-steroidal anti-inflammatory drugs) Copper - Copper may enhance the anti-inflammatory effects of NSAIDs. Indomethacin may cause sodium and water retention.
Non-Narcotic Pain Relievers
[Imitrex^®(sumitriptan), Ultram^®(tramadol)] St. John's Wort - Potential interactions may occur. Concomitant administration is not advised unless prescribed by a health care professional.
Oral Contraceptives St. John's Wort - Concomitant use of St. John's Wort and oral contraceptives may reduce the effectiveness of the contraceptives and cause breakthrough bleeding.
Serum Iron and Copper - Oral contraceptive use has been associated with an increase in iron and copper levels.
Respiratory Corticosteroids Calcium - Calcium absorption was reduced following administration of oral beclomethasone (inhaler), a respiratory steroid similar to Flonase.
Synthetic Thyroid Iron and Soy - Iron supplements and soy products taken at the same time as thyroid hormone replacement may interfere with absorption. Thyroid hormone absorption is increased when taken on an empty stomach. Thyroid hormones should be taken an hour before eating, at the same time every day.

For support of overall health in any individual, the appropriate comprehensive age- and gender-specific multiple formula, flax oil, and multiple antioxidant formula are recommended. However, for a specific potential deficiency, individuals may add single ingredient supplements to assure repletion. It is important to consider the quality and bioavailability of vitamin and mineral supplements used for these purposes.

Make It A Fiber Fusion DAy

If you benefit from the daily cleanse of Fiber Fusion but desire a more thorough cleanse, try taking the gentle journey to rejuvenation with Whole Body cleanse. Using only natural herbs and plants and containing no harsh stimulant laxatives, Whole Body Cleanse safely restores your body's own natural balance in just 14 days. To maintain your healthy digestive system, try Acidophilus Pearls. These pearls replenish intestinal flora with one billion live beneficial bacteria, delivered by patented True Delivery Technology. Delivers up to 900% more intact microflora than the competing brands.

Fiber Fusion FAQ

How much soluble fiber is provided in one serving of Fiber Fusion?
Fiber Fusion provides 4 grams of dietary fiber per serving. Of this, greater than 50 percent, or more than 2 grams, is soluble fiber.

Will Fiber Fusion affect the absorption of prescription medications?
Fiber may slow the absorption of prescription medications, therefore we recommend that prescription medications not be taken at the same time as any fiber supplement. Generally, waiting at least 2 hours between taking fiber and prescription medications is sufficient, but please discuss the use of dietary supplements with your healthcare practitioner.

I started taking Fiber Fusion and I’ve noticed I feel very gassy. What should I do?
Because many people do not get very much fiber in their daily diets, when they do increase their fiber intake they experience gas or sometimes occasional constipation or diarrhea. The key to successfully increasing fiber intake without experiencing adverse effects is to gradually increase your fiber and make sure you get plenty of water. Start with 1/2 or 1/3 of the daily dosage and increase gradually over a few weeks. Some people find that adding a good probiotic, such as Acidophilous Pearls active cultures, also helps relieve any fiber-associated gas. The benefits of fiber are many, so don’t give up on this important nutrient.

What is True Dispersion Technology?
Patent-pending True Dispersion Technology fiber ensures that the psyllium, other ingredients such as oat bran, guar gum, pectin, and marshmallow root, are completely released and dispersed for thorough colon cleansing. Encapsulated fiber supplements which do not disperse well are not only uncomfortable to pass through the digestive track, but also have limited surface area in which to trap and bind products of detoxification. Because True Dispersion Technology fiber completely disperses, it is both comfortable and provides superior surface area to bind toxins for elimination.*

Why was psyllium chosen as the source of fiber in Fiber Fusion?
Psyllium is one of the most preferred cleansing fibers because of its well documented and wide-ranging benefits. Not only is psyllium an excellent source of soluble fiber, it is also a superior binder of toxins, absorbing up to up to fourteen times its weight. Psyllium has been shown increase stool bulk by up to 100 percent and water content by up to 50 percent making elimination more regular, efficient, and comfortable. In addition, psyllium supports healthy cardiovascular, endocrine, and immune function and plays a role in healthy microflora balance.

Drug Nutrient Interaction Chart References

Anti-anxiety

Miller LG. Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158:2200-2211. Abstract.
Spinella M, Eaton LA. Hypomania induced by herbal and pha,aceutical psychotropic medicines following mild traumatic brain injury. Brain Inj. 2002 Apr; 16(4):359-67. (see reference SSRIs)
Dannawi M. Possible serotonin syndrom after combination of buspirone and St. John's Wort J Psychopharmacol. 2002 Dec; 16(4):401. No abstract available.
Lilja JJ, Kivisto KT, Backman JT, et al. Grapefruit juice substantially increases plasma concentrations of buspirone. Clin Pharmacol Ther. 1998 Dec; 64(6):655-60.

Antibiotics

Breen GA. Hypoprothrombinemia associated with cefmetazole Ann Pharmacother. 1997 Feb 31 (2) :180-4.
Pelton R. LaValle JB. Drugs and Their Effects on Nutrition. In: The Nutritional Cost of Perscription Drugs. 2nd Edition Englewood, CO: Morton Publishing Company; 2004, 34-35.
Horowitz S. Combining supplements and perscription drugs. Altern Complete Ther. 2000.pp.306.
Brinker F. Vitamin/mineral/drug interactions. In:Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp.306
Foulds G, Hilligoss DM, Henery EB, Gerber N. The effects of an antacid or cimetidine on the serum concentrations of azithromycin. J Clin Pharmacol. 1991; 31:164-167. Abstract.
Flockhart DA, Desta Z, Mahal SK. Selection of drugs to treat gastro-oesophageal reflux diease: the role of drug interactions. Clin Pharmakinet. 2000 Oct;39 (4):295-309.

Anti-Diabetic

Nestler JE, Beer NA, Jakubowicz DJ, et al. Effects of a reduction in circulating insulin by metformin on serum dehdtorpiandrosterone sulfate in nondiabetic men J Clin Endocrinol Metab. 1994 Mar;78(3):549-54.
Crave JC, Fimbel S, Lejeune H, et al. Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women. J Clin Endocrinol Metab. 1995 Jul; 80(7):2057-62.

AntiHistamines

Izzo AA. Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence. Int J Clin Pharmacol Ther. 2004 Mar; 42(3):139-48.
Wang Z, Hamman MA, Huang SM, et al. Effect of St. John's Wort on the pharmacokinetics of fexofenadine. Clin Pharmacol Ther. 20002 Jun; 71(6):414-20.
Dresser GK, Bailey DG. The effects of fruit juices on drug disposition: a new model for drug interactions. Eur J Clin Invest. 2003 Nov; 33 Suppl 2:10-6.

Anti-Psychotics

Dursun SM, Oluboka OJ, Devarajan S, Kutcher SP. High-dose vitamin E plus Vitamin B6 treatment of risperidone-related neuroleptic malignant malignant syndrome. J Psychopharmacol. 1998; 12(2):220-1.
Javitt DC, Silipo G, Cienfuegos A, Shelley AM, et al. Adjunctive high-dose glycine in the treatment of schizophrenia. Int J Neuropsychopharmacol. 2001 Dec; 4(4):385-91.
Heresco-Levy U, Ermilov M, Lichtenberg P, Bar G, Javitt DC. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry. 2004 Jan 15;55(2):165-71.
Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry. 1999 Jan; 156(1):145-7.

Anti-Seizure

Brinker F, Vitamin/mineral/drug interactions In: Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp. 305.
Herbs Ibid. pp 27-42.

Benzodiazepines

Miller LG. Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158:2200-2211. Abstract.
Stevinson C, Huntley A, Ernst E. Systemic review of the safety of kava extract in the treatment of anxiety. Drug Saf 2002;25 (4) :251-61.
Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A enzyme. JAMA. 2003 Sep 17; 290(11):1500-4.

Beta-blockers

Gehr TW, Sica DA. Pharmacotherapy in congestive heart failure: Hyperkalemia in congestive heart failure. Congest Heart Fail. 2001 Mar-Apr; 7(2):97-100.
Rosa RM, Silva P, Young JB, et al. Adrenergic modulation of extrarenal potassium disposal. N Engl J Med. 1980 Feb 21; 302(8):431-4.
Bano G, Raina RK, Zutshi U, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol. 1991; 41(6):615-7.
Laer S, Neumann J, Scholz H. Interaction between sotalol and an antacid preparation. Br J Clin Pharmacol. 1997 Mar; 43(3):269-72.
Sasse M, Paul T, Bergmann P, et al. Sotalol associated torsades de pointes tachycardia in a 15-month-old child: successful therapy with magnesium aspartate. Pacing Clin Electrophysiol. 1998 May; 21(5):1164-6.
Forlani S, Moscarelli M, Scafuri A, et al. Combination therapy for prevention of atrial fibrillation after coronary artery bypass surgery: a randomized trial of sotalol and magnesium. Card Electrophysiol Rev. 2003 Jun; 7(2):168-71.

Calcium Channel Blockers

Haft JI, Habbab MA. Treatment of atrial arrhythmias. Effectiveness of verapamil when preceded by calcium infusion. Arch Intern Med. 1986;146:1085-89. Abstract.
Weiss AT, Lewis BS, Halon DA, et al. The use of calcium with verapamil in the management of supraventricular tachyarrhythmias. Int J Cardiol. 1983;4:275-80. Abstract.
Threlkeld DS, ed. Diuretics and Cardiovasculars, Calcium Channel Blocking Agents.In Facts and Comparisons Drug Information St. Louis, MO; Facts and Comparisons, Nov 1992, 150-150b.
Tannergren C, Engman H, Knutson L, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr; 75(4):298-309.
Bailey DG, Dresser GK, Kreeft JH, et al. Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. Clin Pharmacol Ther. 2000 Nov;68(5):468-77.
Baily DG, Arnold MD, Strong HA, Munoz C, Spence JD, et al. Effect of grapefruit juice and maringin on nisoldipine pharmacokinetics. Cli Pharmacol Ther.1993;54:589-94. Abstract

Diuretics, Potassium-Sparing

Devane J, Ryan MP. The effects of amiloride and triameterene on urinary magnesium excretion in conscious saline-loaded rats. Br J Pharmacol 1981;72:285-89

HIV Antivirals

Henderson L, Yue QY, Bergquist C, et al. St John's wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol. 2002 Oct;54(4):349-56. Review.
James JS. St. John's wort warning: do not combine with protease inhibitors, NNRTIs. AIDS Treat News. 2000 Feb 18 ;( No 337):3-5.
Piras G, Makino M, Baba M. Sho-saiko-to, a traditional Kampo medicine, enhances the anti-HIV-1 activity of lamivudine (3TC) in vitro. Microbiol Immunol. 1997; 41(10):835-9.
Moretti S, Famularo G, Marcellini S, et al. L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1-infected subjects treated with zidovudine and didanosine. Antioxid Redox Signal. 2002 Jun;4(3):391-403.
Lopez O, Bonnefont-Rousselot D, Edeas M, et al. Could antioxidant supplementation reduce antiretroviral therapy-induced chronic stable hyperlactatemia? Biomed Pharmacother. 2003 May-Jun; 57(3-4):113-6.
Patrick L. Nutrients and HIV: part three - N-acetylcysteine, alpha-lipoic acid, L-glutamine, and L-carnitine. Altern Med Rev. 2000 Aug;5(4):290-305. Review.
Gogu SR, Agrawal KC. The protective role of zinc and N-acetylcysteine in modulating zidovudine induced hematopoietic toxicity. Life Sci. 1996; 59(16):1323-9.
Gogu SR, Beckman BS, Rangan SR, Agrawal KC. Increased therapeutic efficacy of zidovudine in combination with vitamin E. Biochem Biophys Res Commun. 1989 Nov 30;165(1):401-7
Wang Y, Watson RR. Is vitamin E supplementation a useful agent in AIDS therapy? Prog Food Nutr Sci. 1993 Oct-Dec;17(4):351-75. Review.
de la Asuncion JG, del Olmo ML, Sastre J, et al. AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins. J Clin Invest. 1998 Jul 1; 102(1):4-9.

NSAIDs (non-steroidal anti-inflammatory drugs)

Sorenson JRJ. Copper chelates as possible active forms of the antiartritic agents. J Medicinal Chem 1976;19:135-48.
Somova L, Zaharieva S, Ivanova M. Humoral factors involved in the regulation of sodium-fluid balance in normal man. II. Effects of indomethacin on sodium concentration, renal prostaglandins, vasopressin and renin-angiotensin-aldosterone system. Acta Physiol Pharmacol Bulg 1984;10:29-33.

Non-Narcotic Pain Relievers

Brinker F, Vitamin/mineral/drug interactions In: Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp. 183

Oral Contraceptives

Newhouse IJ, Clement DB, Lai C. Effects of iron supplementation and discontinuation on serum copper, zinc, calcium, and magnesium levels in women. Med Sci Sports Exerc. 1993 May; 25(5):562-71.
Milman N, Rosdahl N, Lyhne N, et al. Iron status in Danish women aged 35-65 years. Relation to menstruation and method of contraception. Acta Obstet Gynecol Scand. 1993 Nov; 72(8):601-5.
Frassinelli-Gunderson EP, Margen S, Brown JR. Iron stores in users of oral contraceptive agents. Am J Clin Nutr. 1985 Apr; 41(4):703-12.

Respiratory Corticosteroids

Smith BJ, Phillips PJ, Pannall PR, et al. Effect of orally administered beclomethasone dipropionate on calcium absorption from the gut in normal subjects. Thorax. 1993 Sep; 48(9):890-3.

Synthetic Thyroid

Beard JL, Borel M, Peterson FJ. Changes in iron status during weight loss with verylow-energy diets. Am J Clin Nutr. 1997;66:104-110. Abstract.
Beard JL, Borel MJ, Derr J. Impaired thermoregulation and thyroid function in iron deficiency anemia. Am J Clin Nutr 1990;52:813-819. Abstract.
Campbell NR, Hasinoff BB. Iron supplements: A comon cause of drug interactions. Brit J Clin Pharmacol. 1991;31:251-255. Abstract.
Jabbar MA, Larrea J, Shaw RA. Abnormal thyroid function tests in infants with congenital hypothyroidism: The influence of soy-based formulas. J Am Coll Nutr 1997;16:280-282. Abstract.
Threlkeld DS, ed. Hormones, Thyroid Hormones. In: Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons; 1991:131-133c.

Additional References

1. Nick GL. Psylium. In: Clinical Purification: A Complete Treatment and Reference Manual. Brookfield, Wis: Longevity Through Prevention Books; 2001: 183-190.
2. Oliver SD. The long-term safety and tolerability of ispaghula husk. J R Soc Health. 2000;120:107-11.
3. Sierra M, Garcia JJ, Fernandez N, Diez MJ, Calle AP. Therapeutic effects of psyllium in type 2 diabetic patients. Eur J Clin Nutr. 2002;56:830-42.
4. Jenkins DJ, Kendall CW, Vuksan V, et al. Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. Am J Clin Nutr. 2002;75:834-9.
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