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Enzymatic Therapy

Fatigued To Fantastic! Energy Revitalization System - Citrus Delight
by Enzymatic Therapy
7 single-serve packets

Energy Support In Tasty, Convenient Drink Mix Packets! (Citrus Flavor)*

Our Price: $9.86
Retail Price: $18.95
You Save: $9.09 each, a 48% Savings!

Fatigued to Fantastic! (Citrus Delight) delivers massive health benefits from over 50 vitamins, minerals and nutrients – conveniently, to keep life simple. Traditional multivitamins only supply a fraction of the nutrients you need to feel energized for an entire day. Vitality could be as easy as choosing the right solution - one that packs a powerful punch for nutrition and energy.*

Our lives are filled with energy draining days – inadequate nutrition, occasional sleeplessness and stress all leave us feeling zapped of energy. Fatigued to Fantastic! Energy Revitalization System provides supercharged energy without caffeine. It enhances vitality in two weeks or less, and improves energy levels by 76% after just three months! Featured here in delicious Berry Splash flavor.*

This product is part of the Fatigued to Fantastic! line of products, which was developed by Jacob Teitelbaum, M.D. to create a solid foundation for vitality and health. It was also formulated to provide the necessary nutrients at the right levels to safely and powerfully achieve peak energy. Dr. Teitelbaum's clinical experience shows that most people will feel a difference within two to three weeks of starting Fatigued to Fantastic!*

How Does It Work?
Sufficient human energy levels are required for all physiologic functions, including muscle contractions, transportation of ions and molecules, and the synthesis of enzymes, hormones, and other macromolecules. Energy metabolism, the conversion of nutrients and oxygen into fuel, is a continuous process that takes place within the mitochondria, unique cellular structures. Mitochondrial energy production follows precise metabolic pathways and requires specific molecules, cofactors, and enzymes. The resulting product is the special carrier for cellular energy, adenosine triphosphate (ATP). The energy released from ATP powers all physiologic functions.*

Any dysfunction along the complex and multi-stepped process of cellular energy metabolism may result in insufficient ATP production. Consequently, physiologic functions may be significantly affected. Muscle contractions may be weak, ions and molecules may not be transported effectively, and enzymatic reactions may be insufficient. The result is often fatigue, that state following a period of mental or bodily activity, characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of occasional weariness, sleepiness, or irritability. Healthy human energy metabolism is crucial to sufficient ATP production.*

Adequate nutrition is, in turn, crucial to healthy human energy metabolism. Without the optimal daily intake of vitamins, minerals, and amino acids, energy, in the form of ATP, cannot be produced. Even with adequate nutritional intake, energy demands often exceed energy stores, especially in the presence of emotional, spiritual, and physical stressors. Continued occasional imbalances in energy levels may result in disrupted healthy energy metabolism.*

Each individual ingredient in Fatigued to Fantastic! Energy Revitalization System provides significant nutritional support for healthy energy metabolism. *

Vitamin A (as 50% beta carotene and retinyl acetate) helps support healthy skin and mucous membrane integrity. It also supports healthy immune system responses as well as healthy bone growth and healthy reproductive processes. Beta-carotene is an antioxidant and free radical fighter.*

Vitamin C (ascorbic acid) is necessary for the proper functioning of the immune system. It is also an antioxidant, free radical fighter and ssists with hormone synthesis. It supports healthy skin integrity and healthy iron absorption.*

Vitamin D (as cholecalciferol) supports healthy metabolism of calcium and phosphorus. It also supports the absorption of vitamin A and bone mineralization.*

Vitamin E (d-alpha-tocopheryl acetate) helps oxygen circulation, supports healthy nerve transmissions and healthy leg nerves and muscles, and helps boost energy levels.*

Biotin supports healthy hair and scalp tissue and also helps healthy skin and muscles.*

Iodine (as potassium iodide) supports healthy metabolic rate and healthy growth regulation.*

Magnesium (as magnesium glycinate) supports enzyme activity involved in energy production, healthy nerve and muscle function and healthy immune system functions.*

Zinc (as zinc sulfate) supports a healthy immune system. It also supports healthy enzyme processes and healthy immune response.*

Selenium (as L-selenomethionine), along with vitamin E, supports healthy cell membranes; supports healthy thyroid functioning.*

Copper (as copper gluconate) supports healthy energy metabolism and healthy skin integrity, and also supports helps iron utilization.*

Manganese (as manganese sulfate) supports healthy metabolic reactions.*

Chromium (as chromium picolinate) supports healthy carbohydrate metabolism, helps regulate healthy blood glucose concentration, and may increase insulin binding and the number of insulin receptors.*

Molybdenum (as sodium molybdate) supports healthy iron metabolism, healthy uric acid production, and healthy sexual functioning in men.*

Potassium (as potassium citrate) supports a healthy nervous system, regular heart rhythm and proper muscle contraction, especially healthy cardiac muscle contraction.*

Whey protein supports healthy muscle and tissue formation, as well as healthy immune system functioning.*

Malic acid is a catalyst that stimulates the complete burning of fuel for energy and supports healthy connective tissue and muscle functioning.*

Inositol supports healthy nerve cell transmission.*

Inulin (from chicory root) supports healthy mineral absorption and healthy immune system responses. It also helps with lipid and glucose metabolism.*

Betaine works with B vitamins to synthesize amino acids and is a precursor to SAM-e.*

Hesperidin 50% (from citrus fruits) is a flavonoid that displays antioxidant activity and prevents free radical damage. It also supports healthy lipid metabolism, healthy vascular functioning, and healthy immunity.*

L-Taurine is a non-protein amino acid that helps stabilize the excitability of nervous system membranes. It also assists in healthy aging mechanisms and aids in the clearing of free radical wastes.*

Glycine is a protein amino acid that helps trigger the release of oxygen to the energy requiring cell-making process. It also supports the manufacturing of hormones responsible for a healthy immune system.*

L-Tyrosine is an amino acid that supports healthy nerve transmission, as well as healthy functioning of the thyroid, adrenal, and pituitary glands.*

N-Acetylcysteine (NAC) is a form of the amino acid cysteine. It enhances the production of the enzyme glutathione, a powerful antioxidant. It also supports healthy immune and liver functioning, healthy mucous production, and antioxidant activity.*

L-Serine is amino acid that helps strengthen the immune system. It also supports synthesis of fatty acid sheath around nerve fibers.*

Boron (as sodium borate) supports healthy bone and joint function, muscle health, and muscle synthesis.*

Amino acids, nitrogen-containing organic compounds composing the structure of proteins, are the building blocks of protein. They are essential to human metabolism and to making the human body function properly for good health. All but one of the neurotransmitters are composed of amino acids; 95% of hormones are amino acids. Amino acids are key to every human bodily function with every chemical reaction that occurs.*

While each individual ingredient in Fatigued to Fantastic! Energy Revitalization System provides significant nutritional support for healthy energy metabolism, it is theorized that when they are taken together synergistic effects will be noted. Due to the observed interdependency and known interactions of the vitamins, minerals, and amino acids contained in Fatigued to Fantastic! Energy Revitalization System, significant support of healthy energy metabolism and healthy energy levels may be realized.*

Enzymatic Therapy, Inc. is an FDA-registered Drug Establishment and an AFSII-certified producer of particular organic products.

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Supplement Facts Serving Size: One (1) Packet Drink Mix And One (1) UltraCap Servings Per Container: 7 day supply

	Amount Per Serving	Daily Value
Calories	50
Calories From Fat	5
Total Fat	0.5g	1%
Cholesterol	15mg	5%
Total Carbohydrate	6g	2%
Dietary Fiber	1g	4%
Sugars	1g
Protein	6g	12%

A Proprietary Blend (Drink Mix) Contains:
Vitamin A (As 50 Percent Beta Carotene And As Retinyl Acetate)	7,000 IU	140%
Vitamin C (Ascorbic Acid)	750 mg	1,250%
Vitamin D (As Cholecalciferol)	600 IU	150%
Vitamin E (As D-alpha Tocopheryl Acetate)	100 IU	333%
Riboflavin (Vitamin B-2)	17 mg	1,000%
Biotin	200 mcg	67%
Iodine (As Potassium Iodide)	150 mcg	100%
Magnesium (As Magnesium Glycinate)	200 mg	50%
Zinc (As Zinc Sulfate)	15 mg	100%
Selenium (As L-Selenomethionine)	200 mcg	286%
Copper (As Copper Gluconate)	500 mcg	25%
Manganese (As Manganese Citrate)	4 mg	200%
Chromium (As Chromium Picolinate)	200 mcg	167%
Molybdenum (As Sodium Molybdate)	250 mcg	333%
Sodium	30 mg	1%
Potassium (From Whey Protein, Guar Gum, Potassium Citrate, And Potassium Iodide)	55 mg	2%
Whey Protein (milk)	7 g	**
Malic Acid	900 mg	**
Betaine	750 mg	**
Inositol	750 mg	**
Inulin (From Chicory Root)	750 mg	**
Taurine	500 mg	**
Hesperidin 50 percent (from citrus fruits)	500 mg	**
Glycine	390 mg	**
L-Tyrosine	377 mg	**
N-Acetyl-L-Cysteine (NAC)	250 mg	**
L-Serine	240 mg	**
Stevia Leaf Extract (Stevia Rebaudiana) 15:1	53 mg	**
Boron (As Sodium Borate)	2 mg	**
Typical Amino Acid Profile Per Serving:
L-Arginine	300 mg	**
L-Aspartic Acid	665 mg	**
L-Cystine	65 mg	**
L-Glutamic Acid	1,090 mg	**
Glycine	500 mg	**
L-Histidine	105 mg	**
L-Isoleucine	350 mg	**
L-Leucine	630 mg	**
L-Lysine	550 mg	**
L-Methionine	125 mg	**
L-Phenylalanine	180 mg	**
L-Proline	385 mg	**
L-Serine	540 mg	**
Taurine	500 mg	**
L-Threonine	415 mg	**
L-Tryptophan	115 mg	**
L-Tyrosine	525 mg	**
L-Valine	340 mg	**
Total	7,525 mg	**

A Proprietary Blend UltraCap includes:
Thiamin (as thiamin HCl) (vitamin B1)	75 mg	5,000%
Riboflavin (Vitamin B-2)	75 mg	4,412%
Niacin (As Niacinamide)	50 mg	250%
Vitamin B6 (As Pyridoxine HCI)	85 mg	4,250%
Folic Acid	800 mcg	200%
Vitamin B12 (As Cyanocobalamin)	500 mcg	8,333%
Pantothenic Acid (As Calcium D-pantothenate)	50 mg	500%
Choline (Bitartrate)	100 mg	**

Caloric information is for drink mix.

** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet.

Other Ingredients

Citric Acid, Guar Gum, Magnesium Stearate, Modified Cellulose Gum, Natural Flavor, Natural Orange Flavor, Potassium Bicarbonate, Silicon Dioxide, Soy Lecithin, Soybean Oil, Tricalcium Phosphate, Vegetable Juice Color, Vegetable Polysaccharide (Capsule)

Suggested Use

Each morning, mix one (1) level scoop with eight to twelve (8-12) ounces of water, or more as recommended by your healthcare practitioner. In addition, one (1) UltraCap (Daily Energy B Complex) daily, or more as recommended by your healthcare practitioner. Designed to be used together for best results. Energy Enfusion (drink mix) may be mixed with yogurt, juice or other beverage.

Warnings

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use. ... Keep bottle tightly closed.

Allergen Info

This product contains NO yeast, wheat, gluten, corn, artificial flavoring or preservatives. All colors used are from natural sources. Color variations are normal. ... CONTAINS milk derivatives.

Applicable Functions

Endurance, Immune Deficiency, Immune System Support, Stress, Vitamin Deficiency

Related Structure Groups

Adrenal, Immune System

About Enzymatic Therapy

Nature Makes it Pure. Science Makes it Work.

Our People
Enzymatic Therapy sparks with an enthusiasm that comes from knowing we're helping create the best supplement products in the nation.

Our team is made of people who are natural explorers; passionate about the healthful ingredients found in nature but committed to finding the most pure and effective combinations backed by rigorous research.

This buzz doesn't just end at the lab door. Everyone here, from our staff of scientists to our crews running the pharmaceutical-grade machinery to our customer service professionals, shares the exuberance of helping improve the health of America one customer at a time.

Our Reputation
Enzymatic Therapy, Inc. is known as the highest quality provider of therapeutic-dosage natural healthcare products and nutritional supplements in the nation. We strive to be the best for your health.

Our Difference
One thing that sets us apart from the others is the way we make our products. Everything, including raw material evaluation, supplier selection, laboratory analysis and manufacturing standards, is set to conform to the FDA's verified Good Manufacturing Practices, known in the industry as "GMPs."

Our Brands

Quick Tips

Good health doesn't have to be complicated. There are plenty of common-sense steps we can all follow to live better, more active, and fuller lives.

Eat right
We hear this so often it almost loses meaning. Eating right should mean adding things to your diet--more veggies, more fruits, more rich-tasting high-fiber breads and grains. However, it doesn't necessarily mean you have to give up chocolate. After all, there's plenty of beneficial flavonoids in those dark chocolate bars, right? You may just not want to eat chocolate at every meal. Instead of swearing off your favorite (but not healthy) meal forever, try just cutting it down to once or twice a month--make it a treat. As you incorporate more healthy, whole foods into your diet, you'll probably find yourself craving them instead of the bad stuff.

Exercise daily
You don't have to run a marathon or lift your neighbor's house. But, you can start parking a little further away at work each day. Begin taking break time walks, especially if the weather is nice. Dust off that bicycle and see if your friends would like to go for a spin. Almost every town has a dedicated group of folks who do some form of fun exercise. Whatever you do, don't overdo it right off the bat, and choose something you really enjoy. After a couple of weeks, your new exercise regimen will become part of your daily routine, as though it had always been that way.

Strength train your brain
Challenge yourself mentally, and not just by trying to keep up at work. Find a class in your off-hours that teaches something you've always been curious about, but has nothing to do with work. Read a book for fun. Start a board game night with your family. Check out those crossword puzzles. Research in recent years shows that learning new skills and interacting with the world keeps our minds younger much longer. You owe it to yourself to turn off the television and fire up some neurons!

Do something for others
Whether you volunteer for a local environmental group, a food pantry, or your church's annual picnic, people generally feel healthier when their focus is outside of themselves.

Drug Nutrient Interactions

Prescription drug listings are not all-inclusive; the drugs listed below are common examples.

Top Drug Categories Interactions
Anti-anxiety
[Buspar^® (buspirone), Ativan^®(lorezepam) - see Benzodiazepines]
Kava - For reasons similar to benzodiazepines, it is recommended to avoid taking kava with buspirone unless otherwise directed by a licensed health care professional.
St. John's Wort, Ginkgo Biloba - Concurrent use of St. John's Wort and buspirone and St. John's Wort and Ginkgo Biloba with buspirone has resulted in mild serotonin syndrome and should be avoided unless directed by a licensed health care professional.
Grapefruit Juice - Concomitant administration of buspirone and grapefruit juice should be avoided as it increased the concentration of buspirone in the blood.
Antibiotics
(General) Vitamin K - The use of cefmetazole sodium has been associated with hypoprothrombinrmia and treated with Vitamin K supplementation.
Antibiotics

(Aminoglycosides, Cephalosporins, Macrolides, Penicillins, Quinolones, Sulfonamides, Tetracyclines) Calcium, Iron, Magnesium, and Zinc - May prevent the absorption of tetracycline, ciproflaxin, and other antibiotics.
Antibiotics

Gentamycin and Penicillians Potassium Chloride - Concomitant administration of gentamycin with potassium chloride may lower the absorption of potassium chloride.
Antibiotics

Extended spectrum Macrolides [Biaxin^®(clarithromycin), Zithromax^®(azithromycin), Erythromycin, and Tetracyclines] Antacids - Antacids containing magnesium and aluminum have been shown to interfere with azithromycin absorption. People can avoid this by taking azithromycin two hours before or after any aluminum or magnesium containing products. Studies show the magnesium typically found in supplements affects absorption of azythromycin.
Anti-Diabetic
[Glucophage^®(metaformin), Actos^®, Avandia^®(pioglitazone)] DHEA(Dehydroepiandrosterone) - Metaformin has been shown to increase levels of DHEA in blood.
Antihistamines

[Claratin^®(loratadine), Allegra^®(fexofenadine)]
St. John's Wort - Concomitant use of St. John's Wort can have an effect on plasma levels of fexofenadine.
Fruit Juices - Co-administration of grapefruit, orange, and apple juices decreases the absorption of fexofenadine.
Anti-Psychotics
[Zyprexa^®(olanzapine), Risperdal^®(risperidone)]
Vitamin B₆ and E - Reported to effectively treat risperidone -related neuroleptic malignant syndrome.
Glycine - Glycine in combination with antiphychotic treatment has shown significant effects on the effectiveness of these drugs. While adjunctive glycine treatment has been shown to improve negative symptoms in combination with clozapine, olanzapine, and risperidone. Additional studies have shown it to be ineffective in combination with clozapine.
Supplementation with glycine in combination with an antipsychotic should only be done under the supervision of a health care professional.
Anti-Seizure

[Tegretol^®(carbamazepine), Dilantin^®(phenytoin), phenobarbital and Mysoline^®(primidone). Depakene^®(valproic acid) and Depakote^®(divalproex) are also anticonvulsant drugs.] Magnesium, Black Pepper, and Caffeine - Concomitant administration of phenytoin (Dilantin^®) or phenobarbital with magnesium oxide may lower magnesium oxide's absorption. Concomitant administration of Dilantin^® and black pepper and/or long pepper may cause the phenytoin to be absorbed more rapidly and eliminated more slowly. Phenytoin also increases the metabolism and loss of caffeine from the body.
Benzodiazepines
Kava - Due to the similarity of effects, it is usually recommended to avoid taking Kava with Benzodiazepines unless otherwise directed by a licensed health care professional.
St. John's Wort - Concomitant administration of St. John's Wort with alprazolam and should be avoided unless otherwise directed by a licensed health care professional.
Beta-Blockers Potassium - Concomitant use of certain Beta-Blockers may increase potassium levels.
Pepper (Piper Nigrum, Piper Longum) - In single dose human study, piperine, a chemical found in black pepper and long pepper, was reported to increase blood levels of propranolol, which could increase the activity and risks of the drug's side effects.
Antacids - One study showed a reduction in absorption of Sotalol(Betapace^®) when taken concomitantly with an aluminum oxide or magnesium hydroxideantacid. This interaction can be avoided by taking the medication two hours apart.
Magnesium - Magnesium has been effectively used to treat heart arrythmias that have resulted from administration of Sotalol(Betapace^®).
Calcium Channel Blockers Calcium - High level calcium supplementation may reverse the blood pressure-lowering actions of some calcium channel blocker drugs.
Vitamin D - Vitamin D may interfere with the effectiveness of verapamil.
St. John's Wort - A recent study showed that St. John's Wort decreased the bioavailability of R- and S-verapamil.
Fruit Juices - Ingestion of grapefruit, grapefruit juice, and grapefruit products has been shown to increase the adverse effects of calcium channel blockers or similar drugs.
Diuretics, Potassium-Sparing

[Amiloride, Aldactone^®(spironolactone), Dytac^®(triamterene)] Magnesium - Magnesium tends to be preserved.
HIV Antivirals St. John's Wort - St. John's Wort has been shown to speed up the elimination of indinavir which may result in resistance to the drug. St. John's Wort should not be taken concomitantly with HIV Antivirals.
Sho-Saiko-To - This herbal medicine has been shown to enhance the antiviral activity of lamivudine.
Carnitine- Depletion of Carnitine levels may be responsible for muscle and nerve damage in patients on Antiviral therapies. Canitine supplementation is recommended.
Antioxidants- A small study showed a positive effect of antioxidant supplementation on hyperlactatemia (elevated levels of lactate in the systemic circulation) in patients on long-term Antiviral therapy.
N-Aceylt Cysteine- Studies have shown supplementation a NAC during Antiviral therapy may reduce AZT toxicity.
Vitamins E and C- Supplementation with Vitamin E has shown to improve the efficacy of AZT and supplementation with Vitamins E and C may reduce AZT-related cellular damage.
NSAIDs (non-steroidal anti-inflammatory drugs) Copper - Copper may enhance the anti-inflammatory effects of NSAIDs. Indomethacin may cause sodium and water retention.
Non-Narcotic Pain Relievers
[Imitrex^®(sumitriptan), Ultram^®(tramadol)] St. John's Wort - Potential interactions may occur. Concomitant administration is not advised unless prescribed by a health care professional.
Oral Contraceptives St. John's Wort - Concomitant use of St. John's Wort and oral contraceptives may reduce the effectiveness of the contraceptives and cause breakthrough bleeding.
Serum Iron and Copper - Oral contraceptive use has been associated with an increase in iron and copper levels.
Respiratory Corticosteroids Calcium - Calcium absorption was reduced following administration of oral beclomethasone (inhaler), a respiratory steroid similar to Flonase.
Synthetic Thyroid Iron and Soy - Iron supplements and soy products taken at the same time as thyroid hormone replacement may interfere with absorption. Thyroid hormone absorption is increased when taken on an empty stomach. Thyroid hormones should be taken an hour before eating, at the same time every day.

For support of overall health in any individual, the appropriate comprehensive age- and gender-specific multiple formula, flax oil, and multiple antioxidant formula are recommended. However, for a specific potential deficiency, individuals may add single ingredient supplements to assure repletion. It is important to consider the quality and bioavailability of vitamin and mineral supplements used for these purposes.

Fatigued To Fantastic Energy Revitalization System FAQ

Why does Fatigued to Fantastic! Energy Revitalization System include dairy when so many people cannot tolerate dairy products?
Fatigued to Fantastic! Energy Revitalization System was formulated with Jacob Teitelbaum, MD, recognized energy expert and author of From Fatigued to Fantastic! Dr. Teitelbaum included whey protein in the drink mix because of its high quality and nutritious properties. Whey protein has been shown in clinical studies to support healthy immune function, as well as to support healthy muscle and tissue formation.*

Can I use the Fatigued to Fantastic! Energy Revitalization System if I am sensitive to dairy products?
People with dairy allergies or who are extrememly sensitive to even the smallest amount of dairy protein should not use this product. However, most people with very mild dairy sensitivities or lactose intolerance can safely use this product. Each serving contains a maximum of 7% lactose and 15% casein, which calculates to a maximum 600 mg of lactose and approximately 900 mg of casein. For comparison purposes, there are 10,000 mg to 16,000 mg of lactose in an 8 ounce glass of milk. In other words, people who can tolerate a sip of milk can usually take this product without experiencing significant adverse effects from the dairy protein.*

Should I take a multivitamin if I take Fatigued to Fantastic! Energy Revitalization System every day?
This product includes over 50 vitamins, minerals, and other nutrients. Many people choose to use it in place of a traditional daily multivitamin – especially those who find a drink mix easier to take than large tablets or capsules. However, you may want to consider adding a calcium supplement.*

What impact do B vitamins have on energy levels?
The B vitamins, thiamin (B1), riboflavin (B2), niacinamide (B3), pantothenic acid, B6, B12, and folic acid are notable for their synergistic behavior and are most effective when they are taken together. Because they are water-soluble, they are usually not stored and must be taken on a daily basis. The B vitamins are vital to energy production, specifically in the Krebs Cycle, a metabolic pathway that supplies high-energy electrons to drive mitochondrial ATP production.*

What B vitamins are people most commonly lacking?
A vitamin B deficiency is a common occurrence among the U.S. population and continues to increase as our lives become more stressed. In regard to riboflavin (B2) and methylcobalamin (B12), surveys in the United States reported riboflavin deficiency among the elderly to be between 10 percent and 27 percent. Research has shown that a B12 deficiency occurs in 3 to 40 percent of the general United States population.*

Fatigued to Fantastic! Energy Revitalization System contains a high level of all the B vitamins, especially B12, to help support healthy blood, brain, and nerve cell function, which are essential for optimal energy levels.*

Drug Nutrient Interaction Chart References

Anti-anxiety

Miller LG. Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158:2200-2211. Abstract.
Spinella M, Eaton LA. Hypomania induced by herbal and pha,aceutical psychotropic medicines following mild traumatic brain injury. Brain Inj. 2002 Apr; 16(4):359-67. (see reference SSRIs)
Dannawi M. Possible serotonin syndrom after combination of buspirone and St. John's Wort J Psychopharmacol. 2002 Dec; 16(4):401. No abstract available.
Lilja JJ, Kivisto KT, Backman JT, et al. Grapefruit juice substantially increases plasma concentrations of buspirone. Clin Pharmacol Ther. 1998 Dec; 64(6):655-60.

Antibiotics

Breen GA. Hypoprothrombinemia associated with cefmetazole Ann Pharmacother. 1997 Feb 31 (2) :180-4.
Pelton R. LaValle JB. Drugs and Their Effects on Nutrition. In: The Nutritional Cost of Perscription Drugs. 2nd Edition Englewood, CO: Morton Publishing Company; 2004, 34-35.
Horowitz S. Combining supplements and perscription drugs. Altern Complete Ther. 2000.pp.306.
Brinker F. Vitamin/mineral/drug interactions. In:Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp.306
Foulds G, Hilligoss DM, Henery EB, Gerber N. The effects of an antacid or cimetidine on the serum concentrations of azithromycin. J Clin Pharmacol. 1991; 31:164-167. Abstract.
Flockhart DA, Desta Z, Mahal SK. Selection of drugs to treat gastro-oesophageal reflux diease: the role of drug interactions. Clin Pharmakinet. 2000 Oct;39 (4):295-309.

Anti-Diabetic

Nestler JE, Beer NA, Jakubowicz DJ, et al. Effects of a reduction in circulating insulin by metformin on serum dehdtorpiandrosterone sulfate in nondiabetic men J Clin Endocrinol Metab. 1994 Mar;78(3):549-54.
Crave JC, Fimbel S, Lejeune H, et al. Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women. J Clin Endocrinol Metab. 1995 Jul; 80(7):2057-62.

AntiHistamines

Izzo AA. Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence. Int J Clin Pharmacol Ther. 2004 Mar; 42(3):139-48.
Wang Z, Hamman MA, Huang SM, et al. Effect of St. John's Wort on the pharmacokinetics of fexofenadine. Clin Pharmacol Ther. 20002 Jun; 71(6):414-20.
Dresser GK, Bailey DG. The effects of fruit juices on drug disposition: a new model for drug interactions. Eur J Clin Invest. 2003 Nov; 33 Suppl 2:10-6.

Anti-Psychotics

Dursun SM, Oluboka OJ, Devarajan S, Kutcher SP. High-dose vitamin E plus Vitamin B6 treatment of risperidone-related neuroleptic malignant malignant syndrome. J Psychopharmacol. 1998; 12(2):220-1.
Javitt DC, Silipo G, Cienfuegos A, Shelley AM, et al. Adjunctive high-dose glycine in the treatment of schizophrenia. Int J Neuropsychopharmacol. 2001 Dec; 4(4):385-91.
Heresco-Levy U, Ermilov M, Lichtenberg P, Bar G, Javitt DC. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry. 2004 Jan 15;55(2):165-71.
Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry. 1999 Jan; 156(1):145-7.

Anti-Seizure

Brinker F, Vitamin/mineral/drug interactions In: Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp. 305.
Herbs Ibid. pp 27-42.

Benzodiazepines

Miller LG. Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158:2200-2211. Abstract.
Stevinson C, Huntley A, Ernst E. Systemic review of the safety of kava extract in the treatment of anxiety. Drug Saf 2002;25 (4) :251-61.
Markowitz JS, Donovan JL, DeVane CL, et al. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A enzyme. JAMA. 2003 Sep 17; 290(11):1500-4.

Beta-blockers

Gehr TW, Sica DA. Pharmacotherapy in congestive heart failure: Hyperkalemia in congestive heart failure. Congest Heart Fail. 2001 Mar-Apr; 7(2):97-100.
Rosa RM, Silva P, Young JB, et al. Adrenergic modulation of extrarenal potassium disposal. N Engl J Med. 1980 Feb 21; 302(8):431-4.
Bano G, Raina RK, Zutshi U, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol. 1991; 41(6):615-7.
Laer S, Neumann J, Scholz H. Interaction between sotalol and an antacid preparation. Br J Clin Pharmacol. 1997 Mar; 43(3):269-72.
Sasse M, Paul T, Bergmann P, et al. Sotalol associated torsades de pointes tachycardia in a 15-month-old child: successful therapy with magnesium aspartate. Pacing Clin Electrophysiol. 1998 May; 21(5):1164-6.
Forlani S, Moscarelli M, Scafuri A, et al. Combination therapy for prevention of atrial fibrillation after coronary artery bypass surgery: a randomized trial of sotalol and magnesium. Card Electrophysiol Rev. 2003 Jun; 7(2):168-71.

Calcium Channel Blockers

Haft JI, Habbab MA. Treatment of atrial arrhythmias. Effectiveness of verapamil when preceded by calcium infusion. Arch Intern Med. 1986;146:1085-89. Abstract.
Weiss AT, Lewis BS, Halon DA, et al. The use of calcium with verapamil in the management of supraventricular tachyarrhythmias. Int J Cardiol. 1983;4:275-80. Abstract.
Threlkeld DS, ed. Diuretics and Cardiovasculars, Calcium Channel Blocking Agents.In Facts and Comparisons Drug Information St. Louis, MO; Facts and Comparisons, Nov 1992, 150-150b.
Tannergren C, Engman H, Knutson L, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr; 75(4):298-309.
Bailey DG, Dresser GK, Kreeft JH, et al. Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. Clin Pharmacol Ther. 2000 Nov;68(5):468-77.
Baily DG, Arnold MD, Strong HA, Munoz C, Spence JD, et al. Effect of grapefruit juice and maringin on nisoldipine pharmacokinetics. Cli Pharmacol Ther.1993;54:589-94. Abstract

Diuretics, Potassium-Sparing

Devane J, Ryan MP. The effects of amiloride and triameterene on urinary magnesium excretion in conscious saline-loaded rats. Br J Pharmacol 1981;72:285-89

HIV Antivirals

Henderson L, Yue QY, Bergquist C, et al. St John's wort (Hypericum perforatum): drug interactions and clinical outcomes. Br J Clin Pharmacol. 2002 Oct;54(4):349-56. Review.
James JS. St. John's wort warning: do not combine with protease inhibitors, NNRTIs. AIDS Treat News. 2000 Feb 18 ;( No 337):3-5.
Piras G, Makino M, Baba M. Sho-saiko-to, a traditional Kampo medicine, enhances the anti-HIV-1 activity of lamivudine (3TC) in vitro. Microbiol Immunol. 1997; 41(10):835-9.
Moretti S, Famularo G, Marcellini S, et al. L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1-infected subjects treated with zidovudine and didanosine. Antioxid Redox Signal. 2002 Jun;4(3):391-403.
Lopez O, Bonnefont-Rousselot D, Edeas M, et al. Could antioxidant supplementation reduce antiretroviral therapy-induced chronic stable hyperlactatemia? Biomed Pharmacother. 2003 May-Jun; 57(3-4):113-6.
Patrick L. Nutrients and HIV: part three - N-acetylcysteine, alpha-lipoic acid, L-glutamine, and L-carnitine. Altern Med Rev. 2000 Aug;5(4):290-305. Review.
Gogu SR, Agrawal KC. The protective role of zinc and N-acetylcysteine in modulating zidovudine induced hematopoietic toxicity. Life Sci. 1996; 59(16):1323-9.
Gogu SR, Beckman BS, Rangan SR, Agrawal KC. Increased therapeutic efficacy of zidovudine in combination with vitamin E. Biochem Biophys Res Commun. 1989 Nov 30;165(1):401-7
Wang Y, Watson RR. Is vitamin E supplementation a useful agent in AIDS therapy? Prog Food Nutr Sci. 1993 Oct-Dec;17(4):351-75. Review.
de la Asuncion JG, del Olmo ML, Sastre J, et al. AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins. J Clin Invest. 1998 Jul 1; 102(1):4-9.

NSAIDs (non-steroidal anti-inflammatory drugs)

Sorenson JRJ. Copper chelates as possible active forms of the antiartritic agents. J Medicinal Chem 1976;19:135-48.
Somova L, Zaharieva S, Ivanova M. Humoral factors involved in the regulation of sodium-fluid balance in normal man. II. Effects of indomethacin on sodium concentration, renal prostaglandins, vasopressin and renin-angiotensin-aldosterone system. Acta Physiol Pharmacol Bulg 1984;10:29-33.

Non-Narcotic Pain Relievers

Brinker F, Vitamin/mineral/drug interactions In: Herb Contraindications and Drug Interactions. 3rd ed. Dandy, Ore: Eclectic Medical Publications; 2001.pp. 183

Oral Contraceptives

Newhouse IJ, Clement DB, Lai C. Effects of iron supplementation and discontinuation on serum copper, zinc, calcium, and magnesium levels in women. Med Sci Sports Exerc. 1993 May; 25(5):562-71.
Milman N, Rosdahl N, Lyhne N, et al. Iron status in Danish women aged 35-65 years. Relation to menstruation and method of contraception. Acta Obstet Gynecol Scand. 1993 Nov; 72(8):601-5.
Frassinelli-Gunderson EP, Margen S, Brown JR. Iron stores in users of oral contraceptive agents. Am J Clin Nutr. 1985 Apr; 41(4):703-12.

Respiratory Corticosteroids

Smith BJ, Phillips PJ, Pannall PR, et al. Effect of orally administered beclomethasone dipropionate on calcium absorption from the gut in normal subjects. Thorax. 1993 Sep; 48(9):890-3.

Synthetic Thyroid

Beard JL, Borel M, Peterson FJ. Changes in iron status during weight loss with very low-energy diets. Am J Clin Nutr. 1997;66:104-110. Abstract.
Beard JL, Borel MJ, Derr J. Impaired thermoregulation and thyroid function in iron deficiency anemia. Am J Clin Nutr 1990;52:813-819. Abstract.
Campbell NR, Hasinoff BB. Iron supplements: A comon cause of drug interactions. Brit J Clin Pharmacol. 1991;31:251-255. Abstract.
Jabbar MA, Larrea J, Shaw RA. Abnormal thyroid function tests in infants with congenital hypothyroidism: The influence of soy-based formulas. J Am Coll Nutr 1997;16:280-282. Abstract.
Threlkeld DS, ed. Hormones, Thyroid Hormones. In: Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons; 1991:131-133c.

Additional References

1. Hultman E, Harris RC, Spriet LL. Energy substrates available for work. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999: 762-764.
2. Grodner M, Anderson SL, DeYoung S. Metabolism. In: Foundations and Clinical Applications of Nutrition: A Nursing Approach. St. Louis, Mo: Mosby; 2000: 76-77.
3. Guyton AC, Hall JE. Extractions of energy from nutrients. Function of the mitochondria. In: Textbook of Medical Physiology. 10th Ed. Philadelphia, Pa: W.B. Saunders Company; 2000:19-21.
4. Jiricka MK. Activity intolerance and fatigue. In: Porth CM. Pathophysiology: Concepts of Altered Health States. 5th ed. Philadelphia, Pa: Lippincott; 1998:1269-1272.
5. Grodner M, Anderson SL, DeYoung S. Vitamin categories. In: Foundations and Clinical Applications of Nutrition: A Nursing Approach. St. Louis, Mo: Mosby; 2000:173-174.
6. Berdanier CD, Everts HB, Hermoyian C, Mathews CE. Role of vitamin A in mitochondrial gene expression. Diabetes Res Clin Pract. 2001;54:S11-27.
7. Bates CJ. Vitamin A. Lancet. 1995;345:31-35.
8. Ross AC. Vitamin A and retinoids. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999:305-328.
9. Nieman DC, Henson DA, McAnulty SR, et al. Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon. J Appl Physiol. 2002;92:1970-7.
10. Li X, Cobb CE, Hill KE, Burk RF, May JM. Mitochondrial uptake and recycling of ascorbic acid. Arch Biochem Biophys. 2001;387:143-53.
11. Jacob RA. Vitamin C. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999:467-483.
12. Brown AJ. Therapeutic uses of vitamin D analogues. Am J Kidney Dis. 2001;3:S3-S19.
13. Miller WL, Portale AA. Genetics of vitamin D biosynthesis and its disorders. Best Pract Res Clin Endocrinol Metab. 2001;15:95-109.
14. Fleming T., ed. VitaminD. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 498-505.
15. Ebrahim AS, Babu E, Thirunavukkarasu C, Sakthisekaran D. Protective role of vitamin E, 2-deoxy-D-glucose, and taurine on perchloroethylene induced alterations in ATPases. Drug Chem Toxicol. 2001;24:429-37.
16. Traber MG, Arai H. Molecular mechanisms of vitamin E transport. Annu Rev Nutr. 1999;19:343-55.
17. Fleming T., ed. Vitamin E. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 505-522.
18. Mock DM. Biotin. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999:459-466.
19. Fleming T., ed. Biotin. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 50-55.
20. Said HM. Biotin: the forgotten vitamin. Am J Clin Nutr. 2002 Feb;75(2):179-80.
21. Hetzel BS, Clugston GA. Iodine. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999:253-264.
22. Shils ME. Magnesium In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999:169-192.
23. Lourenco R, Camilo ME. Magnesium: physiological and clinical relevance. 1: homeostasis and alterations in the metabolism of magnesium. Acta Med Port. 2000;13:211-220.
24. Martini LA. Magnesium supplementation and bone turnover. Nutr Rev. 1999;57:227-229.
25. Reinhart RA. Magnesium metabolism. Wis Med J. 1990 Oct;89:579-583.
26. Lastra MD, Pastelin R, Camacho A, Monroy B, Aguilar AE. Zinc intervention on macrophages and lymphocytes response. J Trace Elem Med Biol. 2001;15:5-10.
27. Micheletti A, Rossi R, Rufini S. Zinc status in athletes: relation to diet and exercise. Sports Med. 2001;31:577-582.
28. Fleming T., ed. Zinc. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 535-540.
29. Combs GF Jr. Impact of selenium and cancer-prevention findings on the nutrition-health paradigm. Nutr Cancer. 2001;40:6-11.
30. Brown KM, Arthur JR. Selenium, selenoproteins and human health: a review. Public Health Nutr. 2001 Apr;4(2B):593-599.
31. 31. Patel JC. Human health and selenium. Indian J Med Sci. 2000 Dec;54(12):563-564.
32. Burk RF, Levander OA. Selenium. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999:262-276.
33. Turnland JR. Copper. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999:241-252.
34. Fleming T., ed. Copper. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 112-114.
35. Neilsen FH. Manganese. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999: 289-292.
36. Keen CL, Ensunsa JL, Watson MH, et al. Nutritional aspects of manganese from experimental studies. Neurotoxicol. 1999;20:213-223.
37. Fleming T., ed. Chromium. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001:96-100.
38. Vincent J. The biochemistry of chromium. J Nutr. 2000;130:715-718.
39. Neilsen FH . Molybdenum. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins;1999: 292-293.
40. Mendel RR. The role of the molybdenum cofactor in humans. BioFactors. 2000;11:147-148.
41. Fleming T., ed. Potassium. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001:368-372.
42. Young DB, Lin H, McCabe RD. Potassium's cardiovascular protective metabolism. Am J Physiol. 1995;268:825-837.
43. YoungDB, Ma G. Vascular protective effects of potassium. Semin Nephrol. 1999;19:477-486.
44. Fleming T., ed. Whey protein. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001:528-530.
45. Wong CW, Watson DL. Immunomodulatory effects of dietary whey proteins in mice. J Dairy Res. 1995:62:359-368.
46. Bounous G, Batist G, Gold P. Whey protein in cancer prevention. Cancer Lett. 1991;57:91-94.
47. Fleming T., ed. Malic acid.. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 295-296.
48. Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, placebo controlled pilot study. J Rheumatol. 1995;22:953-958.
49. Fleming T., ed. Myo-inositol. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001:315-318.
50. Colodny L, Hoffman RL. Inositol? Clinical applications for exogenous use. Altern Med Rev. 1998;3:432-447.
51. Fleming T., ed. Inulin. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 226-228.
52. Roberfroid MB, Delzenne NM. Dietary fructans. Annu Rev Nutr. 1998:18:117-143.
53. Woodlaw G, Insel P. Proteins. In: Perspectives in Nutrition 2nd ed. Mosby; St. Louis Mo., 1993; 139-147.
54. Barak AJ, Beckenhauser HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol. 1996;13(4):395-8.
55. Fleming T., ed. Hesperidin. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 202-211.
56. Galati EM, Monforte MT, Kirjavainen S, et al. Biological effects of hesperidin: a citrus flavonoid (Note I): anti-inflammatory and analgesic activity. Farmaco. 1994;40:709-712.
57. Matthews DE. Proteins and amino acids. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins;1999:11-48.
58. Fleming T., ed. Acetylcysteine. In: PDR for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001:11-14.
59. Nielsen FH. Boron. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins;1999: 286-288.
60. Teitelbaum J, Bird B, Greenfield R, Weiss A, Muenz L, Gould L. Effective treatment of chronic fatigue syndrome and fibromyalgia. A randomized, double blind, placebo-controlled, intent-to-treat study. J Chronic Fatigue Syndrome. 2001;8:3-28.
61. Teitelbaum J, Bird B. Effective treatment of severe chronic fatigue states: A report of a series of 64 patients. J Musculoskeletal Pain. 1995;3:91-110.