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SKU: PP13233

End Fatigue Revitalizing Sleep Formula helps you fall asleep faster, plus maintain a healthy sleep cycle so you wake up energized in the morning. It also helps you rejuvenate your system while you sleep, so you experience less fatigue the following day.*

Benefits
• Helps you get to sleep faster.*
• Allows you to maintain a healthy sleep cycle so you wake up energized.*
• Helps your body—especially your muscles—recuperate while you sleep so you experience less fatigue.*
• No next-day drowsiness, a common side effect of over-the-counter sleep aids.*

Key Features
• Formulated with Jacob Teitelbaum, M.D., recognized fatigue expert and author of From Fatigued to Fantastic!
• Designed to work synergistically with the complete Fatigued to Fantastic! System.

Trouble Sleeping?
Good quality sleep is vital to our health and well being, yet millions of Americans are sleep deprived. For example, surveys conducted by the National Sleep Foundation reveal that 60 percent of adults report not sleeping well a few nights a week or more. In addition, more than 40 percent of adults experience daytime sleepiness severe enough to interfere with their daily activities at least a few days each month - with 20 percent reporting problem sleepiness a few days a week or more.*

Sleeplessness or poor sleep is an occasional problem for over 70 million Americans. Every year, 98 million dollars are spent on over-the-counter sleeping aids and another 50 million on caffeine tablets to stay wake during the day.*

Stages of Sleep
Since the early 20th century, human sleep has been described as a succession of five recurring stages: stages 1 through 4 are non-REM stages and stage 5 is the REM stage. Rapid eye movement (REM) sleep is marked by extensive physiological changes, such as accelerated respiration, increased brain activity, eye movement, and muscle relaxation. People dream during REM sleep, perhaps as a result of excited brain activity and the relaxation of major voluntary muscles.

Sleep quality changes with transition from one sleep stage into another. Although the signals for transition between the five stages of sleep are not well described, it is important to remember that these stages are, in fact, discretely independent of one another, each marked by subtle changes in bodily function and each part of a predictable cycle whose intervals are observable. Sleep stages are monitored and examined clinically with polysomnography, which provides data regarding electrical and muscular states during sleep.The chart below summarizes the different stages of sleep.

The five stages of sleep, including their repetition, occur cyclically. The first cycle, which ends after the completion of the first REM stage, usually lasts for 100 minutes. Each subsequent cycle lasts longer, as its respective REM stage extends. So a person may complete five cycles in a typical night's sleep.

The sleep cycle is variable, influenced by several agents. Sleep cycles subsequent to the first one in a night's sleep typically feature less slow-wave sleep, as Stages 3 and 4 shorten. Slow-wave, deep sleep is longest early in a night's sleep. Generally, sleep disorders affect the quality, duration, and onset of deep sleep. Sleep deprivation, frequently changing sleep schedule, stress, and environment all affect the progression of the sleep cycle.

How much sleep is enough?
Most adults do best with about 8 hours of quality sleep a night until age 60, after which 6 hours may be adequate. Even though the older adults need less sleep, almost one-half of people over 60 experience some degree of occasional sleep difficulties.*

The best measure of the amount of sleep needed is how you feel. If you awaken feeling refreshed, you are probably getting enough quality sleep. For some people, this may take only 4 hours -- others can need up to 10 hours to feel rested. However, the key is to get good quality sleep for optimal daytime energy and functioning.*

How Does It Work?
The combination of ingredients in End Fatigue Revitalizing Sleep Formula is important as each addresses a different aspect of occasional sleeplessness and muscle tension.*

Valerian Root Extract
Valerian (Valeriana officinalis) root extract is included in End Fatigue Revitalizing Sleep Formula to support better sleep at night.* It has been clinically studied for its ability to support sleep. It has an approved monograph in both The German Commission E and the World Health Organization (WHO) Monographs on Selected Medicinal Plants.*

Valerian root extract has been reported to have sleep inducing and calming effects in in-vivo studies and clinical trials. A placebo-controlled, crossover trial of 128 volunteers reported that valerian extract taken at bedtime led to improved sleep quality, decreased sleep latency, and reduced the number of night awakenings. Two other clinical studies using valerian before bedtime also demonstrated improved sleep quality. In a double-blind, cross-over, placebo-controlled trial, subjective sleep latency and wake time after sleep-onset were reduced. One electroencephalographical (EEG) study reported that valerian, taken three times daily, improved deep sleep (stages 3 and 4) and decreased stage 1 sleep.*

Recently, two human trials also demonstrated that valerian extract was effective in improvement of sleep structure and perception in subjects. In general, clinical studies with valerian extracts suggest that the mild sleep-inducing effect of valerian decreases sleep latency and improves sleep quality.*

Passionflower Leaf and Flower Extract 4:1
Passionflower (Passiflora incarnata) extract has been studied for its ability to calm simple nervous tension that may lead to occasional sleeplessness. It has an approved monograph in The German Commission E.*

Passionflower extract has been reported to have calming effects in clinical trials. A recent double-blind randomized controlled trial of 36 volunteers reported that passionflower extract is effective in calming restlessness.*

L-Theanine
Since ancient times, it has been said that drinking green tea brings relaxation. The key ingredient in green tea that provides health benefits is l-theanine. L-theanine is one of the major components of amino acids in green tea. However, L-theanine does not contain caffeine, even though it is from green tea.*

L-theanine's effect on brain amino acids and neurotransmittors has been investigated. In clinical trials, L-theanine causes significant increases of certain neurotransmitter concentrations in brain, such as serotonin and dopamine, which promotes muscle relaxation and improves sleep.*

In a recent study, the brain activity of 50 volunteers was measured after the oral administration of 50-200 mg of L-theanine. L-theanine promoted the generation of alpha-brain waves, considered to be an index of relaxation, in the volunteers. This study concluded that L-theanine promotes relaxation in humans by increasing alpha brain waves.*

Hops Flower Extract 6.6:1
Hops flower (Humulus lupulus) extract has been studied for its ability to calm restlessness and can be used to support restful sleep. It has an approved monograph in The German Commission E.*

The dried strobile of Hops (Humulus lupulus) is a popular sleep aid. Hops have been used for centuries for gastrointestinal health support, and have more recently been used to support healthy sleep. Key constituents of hops include a volatile oil, valerianic acid, phytoestrogenic substances, and tannins.*

Wild Lettuce Extract and Powder
Wild lettuce (Lactuca virosa) extract has been used in traditional medicine for its calmative effect. Wild lettuce has been found to contain the key components of lactucic acid, lactucone, and lactucopicrin. Wild lettuce supports restful sleep by promoting a relaxed feeling.*

Jamaica Dogwood Root Extract
Jamaica Dogwood (Piscidia piscipula) root extract contains isoflavonoids and tannins that help promote restful sleep.* This herb helps individuals fall asleep, and promotes musculoskeletal relaxation. This botanical ingredient has also been found to resolve nervous irritability, thus promoting quality sleep.*

NOTE:  This formula was designed with Jacob Teitelbaum, M.D., recognized fatigue expert and author of From Fatigued to Fantastic! Dr. Teitelbaum's royalties are donated to charity.