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Cran-C-Plex
by Douglas Labs
100 Capsules
Microbial Defense For Urinary Tract Health*
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Cran-C-Plex capsules, provided by Douglas Laboratories, contain a natural concentrate of cranberry juice with additional vitamin C.
Cranberry juice has been recognized over the past few decades for its useful role in supporting urinary tract health. Initially its beneficial properties were attributed to its ability to acidify urine due to its content of organic acids, such as benzoic, malic, quinic, ellagic, shikimic, and citric acids. Metabolism of benzoic acid presumably produces a significant amount of hippuric acid, suggested to be bacteriostatic for Escherichia coli.*
Nevertheless, recent research indicates that other mechanisms may be responsible. These bioactive components of the cranberry (Vaccinium macrocarpon) may support the urinary tract by inhibiting adherence of pathogenic bacteria to urinary epithelial cells and their subsequent proliferation and infection. Bacteria can adhere to epithelial cells via molecules called adhesins, produced by fimbriae, proteinaceous fibers on the bacterial cell surface.*
It appears that two components of cranberry inhibit bacterial adhesion: fructose and proanthocyanidins. Fructose, a sugar typically found in fruit, has been suggested to inhibit adherence of E. coli with type 1 fimbriae, while cranberry proanthocyanidins have been shown to prevent P-fimbriated E. coli from adhering to urinary tract cells. The vitamin C in Cran-C-Plex augments the natural antioxidant power of these proanthocyanidins.*
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Supplement FactsServing Size: One (1) Capsule
Servings Per Container: 100 | | | | Amount
Per Serving | Daily
Value | | Vitamin C | 100 mg | 167% | Cranberry Juice
(Natural Concentrate) | 140 mg | ** | |
** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet. |
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| Gelatin Capsule, Water |
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| As a dietary supplement, one (1) capsule daily, or more as directed by your qualified healthcare consultant. |
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| Keep out of the reach of children. ... Store in a cool, dry place. ... Do not use if outer seal is missing. |
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| This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, preservatives, or artificial coloring/flavoring. |
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| Microbial Imbalances, Urinary, Urinary tract infection |
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| Urinary Tract |
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Avorn J, Monane M, Gurwitz JH, et al. Reduction of bacteriuria and pyuria after ingestion of cranberry juice [see comments]. Jama 1994;271:751-4.
Fleet JC. New support for a folk remedy: cranberry juice reduces bacteriuria and pyuria in elderly women. Nutr Rev 1994;52:168-70.
Hamilton-Miller JM. Reduction of bacteriuria and pyuria using cranberry juice [letter; comment]. Jama 1994;272:588; discussion 589-90.
Howell AB, Vorsa N, Der Marderosian A, et al. Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries [letter]. N Engl J Med 1998;339:1085-6.
Jepson RG, Mihaljevic L, Craig J. Cranberries for treating urinary tract infections. Cochrane Database Syst Rev 2000;2:CD001322.
Kerr KG. Cranberry juice and prevention of recurrent urinary tract infection [letter; comment]. Lancet 1999;353:673.
Kuzminski LN. Cranberry juice and urinary tract infections: is there a beneficial relationship? Nutr Rev 1996;54:S87-90.
Nazarko L. Infection control. The therapeutic uses of cranberry juice.
Nurs Stand 1995;9:33-5.
Ofek I, Goldhar J, Sharon N. Anti-Escherichia coli adhesin activity of cranberry and blueberry juices. Adv Exp Med Biol 1996;408:179-83.
Schmidt DR, Sobota AE. An examination of the anti-adherence activity of cranberry juice on urinary and nonurinary bacterial isolates. Microbios 1988;55:173-81.
Zafriri D, Ofek I, Adar R, et al. Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated Escherichia coli to eucaryotic cells. Antimicrob Agents Chemother 1989;33:92-8. |
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Our Price: $9.90 |
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