Supplement Facts

The Quigley Corporation, the parent company of and , is a Natural Health Medical Science company. Their mission is to develop and market natural healthcare pharmaceuticals and nutriceuticals that offer pioneering new options to improve patient treatment results. The Quigley Corporation's core objective is to address the root cause of illness with the goal of exceeding the efficacy and safety of current treatment options. This approach includes the development of natural compounds and unique methods to deliver those compounds in an effort to innovate medical science and improve patient outcomes.

The Quigley Corporation has divided its operations into three reportable segments: The Quigley Corporation (Cold Remedy), whose main product is Cold-EEZE, a proprietary zinc gluconate glycine lozenge for the common cold; Quigley Manufacturing Incorporated, the manufacturing arm of The Quigley Corporation; and Quigley Pharma (Ethical Pharmaceuticals), currently involved in research and development activity to develop patent applications into commercial pharmaceutical products.

We all know there's no cure for the common cold, but (zinc gluconate glycine) lozenges are the next best thing. Here’s why:

• Cold-EEZE lozenges shorten the life cycle of a cold and restore health faster. Treating with Cold-EEZE can help you get back to your normal routine faster.
• Cold-EEZE reduces the duration and symptoms of the common cold, including cough, stuffy nose, sore throat, sneezing, post-nasal drip and hoarseness.
• The Cold-EEZE proprietary (zinc gluconate glycine) formula is believed by researchers to interfere with the cold virus’ (rhinovirus) ability to reproduce.
• The Cold-EEZE zinc gluconate glycine (ZIGG) was shown to be effective in reducing the duration of the common cold by up to 42% in multiple clinical studies. This could reduce your cold by up to 3 to 4 days.
• The Cold-EEZE brand is the number-one pharmacist-recommended zinc cold treatment. It is recommended two-to-one over Zicam. (Source: Pharmacy Times OTC survey — June 2008)
• Cold-EEZE uses natural flavors and has no preservatives or colors. It is non-drowsy, non-agitating, and safe for patients with high blood pressure.

Cold-EEZE comes in a variety of delicious formulations and flavors: Original Cherry, Original Honey Lemon, Original Tropical Fruit, Original Lemon Lime, Original Strawberries and Cream, Original Green Tea with Honey, and Sugar Free Unflavored.

Not all Natural Homeopathic Cold Remedies and Dietary Supplements are created equal. Because has peer reviewed and published clinical studies that show the powerful and safe effects of its proprietary formula, pharmacists have made it the #1 recommended zinc cold remedy for the past 10 years.

You should choose products that have demonstrated clinical efficacy studies to make sure that you are using a product that has been shown to work. The Cold-EEZE formula has more clinical research than other homeopathic cold remedies and dietary supplements. In fact, unlike Cold-EEZE some products have no studies whatsoever.

Cold-EEZE has clinical studies demonstrating its effectiveness.

• Clinically proven Cold-EEZE lasts longer to shorten your cold.
• Researchers believe that longer dwell time of zinc ions is what makes a zinc remedy work.
• Great tasting Cold-EEZE lasts far longer than Zicam Rapid Melts and Zicam Chewables.

Cold-EEZE had been shown in clinicalstudies to reduce the duration of the common cold by up to 42%.

• 80% of colds are due to the rhinovirus.
• Rhinoviruses have a negative (-) molecular charge.
• Zinc ions have a positive (+) molecular charge.
• Zinc ions are attracted to the rhinovirus like metal filings to a magnet.
• They keep the rhinovirus from effectively reproducing.

Cold-EEZE dissolves more slowly releasing zinc ions evenly for up to 10 minutes.

• Cold-EEZE has 2x the residual zinc ions after 45 minutes.
• Zicam Rapid Melts dissolve in less than 2 minutes offering limited dwell time.
• Only 6% of the zinc ions in Zicam Rapid Melts are available one minute after dissolving.
• What's more, the zinc ions in Zicam oral zinc remedies degrade more quickly after they dissolve.
• Zicam Chewables have 0% available zinc ions at 1 minute, 10 or 20 minutes after dissolving.

It's clear why is the #1 Pharmacist Recommended Zinc Remedy. Cold-EEZE lasts longer between doses, offering extended dwell time of zinc ions. A bio-availability study was conducted showing the change in the actual amount of available zinc ions (Zn²⁺) from 1 minute to 45 min was statistically less for Cold-EEZE than Zicam Oral Melts, indicating that the Zicam Oral Melt degrades more rapidly than the Cold-EEZE lozenge after 45 minutes. (p < .0003) n=30

Blue = ColdEEZE / Pink = Zicam

Common pharmaceutical sweeteners such as sorbitol, mannitol, ascorbic and citric acids will render zinc unable to ionize. These pharmaceutical sweeteners are not present in Cold-EEZE, but are present in most other zinc products. Check all labels before purchasing!

Zinc Gluconate And The Common Cold

A report in 1984 on the success of zinc gluconate against common cold symptoms could not be confirmed in three subsequent studies, which are now known to have used formulations that inactivated zinc. A non-chelating formulation including Glycine, which releases 93% of contained zinc into saliva, was tested in a randomized, placebo-controlled, double-blind trial in 73 young adults. Efficacy was recorded in symptom diaries using a symptom severity rating.

Patients' symptoms first appeared 1.34 days prior to entry into the study in both groups. Disappearance of symptoms occurred after an additional 4.3 days for zinc-treated patients versus 6.1 days for placebo-treated patients. A difference was noted in the efficacy of treatment if it was started 1 day after symptom onset. Cold duration was an additional 4.3 days in zinc-treated patients compared with 9.2 days for placebo-treated patients. Cough, nasal drainage and congestion were the symptoms mostaffected, and only mild side effects were noted.

Safety is a major concern of most people, especially when their health is at stake. That is why has made it a priority to ensure the safety of their products.

Cold-EEZE is safe and effective for all adult patients. There are no significant safety risks or adverse effects associated with Cold-EEZE lozenges, when taken as directed.

• Dissolving lozenges or tablets on a full stomach can prevent most cases of stomach upset.
• Cold-EEZE may alter taste buds. This is normal and temporary.
• Limited drug interaction: When taken at the same time, zinc has been reported to make doxycycline, minocycline, or tetracycline less effective. Take zinc two hours after ingesting doxycycline, minocycline, or tetracycline.

Warnings

Cold-EEZE lozenges are formulated to relieve cold symptoms, and may be insufficient treatment for influenza. If symptoms worsen, or persist beyond 7 days, consult a physician. If pregnant or breast-feeding, ask a health professional before using.

Attention

Cold-EEZE Nasal Spray Users. Please be advised that any Cold-EEZE nasal spray product that you have in your possession or that you might purchase from a retail establishment is currently out of date and should be destroyed immediately.

Dosage

• Zinc can help promote the strength of the immune system, and is required for the development and activation of T-lymphocytes that help fight infection.
• Zinc gluconate glycine (ZIGG), the active ingredient in Cold-EEZE provides 13.3 mg of ionic zinc per lozenge, and 4.3 mg per sugar-free tablet. When taken as directed (up to 6 lozenges; 16 sugar-free tablets per day) there are no significant risks of excessive dosage with Cold-EEZE.
• Although the Recommended Dietary Allowance for zinc is 11 mg for adult men and 8 mg for adult women, much higher doses are typically used for specific complaints.
• The National Institutes of Health have set Upper Limits (ULs) of zinc intake ranging from 4 mg/day to 34 mg/day for children between birth and 18 years of age, and 40 mg/day for adults. However, ULs do not apply to individuals who are receiving zinc for medical treatment.
• The maximum daily intake of zinc (from all sources) should not exceed 150 mg.
• In the event of overdose, inordinate amounts of daily zinc intake (over 300 mg/day over several weeks) have been associated with nausea, vomiting, abdominal cramps, diarrhea, reduced copper status, reduced HDL-cholesterol levels and impaired immunological response.
• When taken as directed, the typical course of therapy for Cold-EEZE results in an intake of 80 mg/day of ionic zinc for 3 to 7 days. When taking into account an average typical dietary zinc intake of 11 mg/day, the total daily intake is well within the limits of safety.

From the Diabetes and Glandular Disease Clinic Study, San Antonio, Texas:

“This study did not detect any deleterious effect of 10 days of dosing with sugar-free Cold-EEZE lozenges on diabetic control as assessed by fructosamine level, fasting blood glucose level and home glucose monitoring.”

A single-center, randomized, single-blind placebo-controlled trial was conducted in patients with diabetes to assess the effects of sugar-free Cold-EEZE tablets on glucose control in patients maintained on stable antidiabetic therapy.

Patients:

• 48 persons with Type 1 or Type 2 diabetes were treated with Cold-EEZE sugar-free zinc or placebo tablets for relief of cold symptoms.
• 13 persons received sugar-free placebo tablets.
• 35 persons received sugar-free Cold-EEZE tablets.

Measures:
Fasting blood glucose level was measured at baseline, study day 10 and study day 21.

Results:
No detrimental effect on overall diabetic control.

Adverse Events:
No patients withdrew from the trial. There were no serious adverse events.

About Cold-EEZE Sugar-Free Tablets:

• Each box contains 48 Zinc Gluconate Glycine (ZIGG) tablets.
• Each tablet contains 4.3 mg of Ionic Zinc.
• Flavor: Unsweetened.
• Recommended daily dose: One tablet per hour, maximum of 16 daily.
• Clinically proven to be safe for people with diabetes.
• Contains 0 carbohydrates, 0 calories.

How do I use Cold-EEZE?
For maximum effectiveness, start taking Cold-EEZE at the first sign of a cold. Symptoms could include one or more of the following: cough, sore throat, stuffy nose, sneezing, post-nasal drip and/or hoarseness. Keep taking Cold-EEZE until all symptoms are gone. Your cold may still last a couple of days after you start taking Cold-EEZE. If Cold-EEZE is stopped too soon, your cold can return to full strength.

To avoid minor stomach upset, do not take Cold-EEZE lozenges or sugar free tablets on an empty stomach. If stomach upset occurs, take Cold-EEZE after you eat something. Citrus fruits or juices may prevent Cold-EEZE from working properly; therefore, do not eat or drink citrus fruits or juices ½ hour before or after taking Cold-EEZE lozenges or tablets. Otherwise, drink plenty of fluids.

If you experience a fever or stomach ache while taking Cold-EEZE, please call your healthcare professional. This can mean you don't have a common cold virus. Other treatment may be needed.

What are the recommended dosages?
Lozenge: Completely dissolve a Cold-EEZE lozenge in mouth. Do not chew. Repeat every 2 to 4 hours as needed. The recommended daily dosage of Cold-EEZE lozenge is 6 per day (79.8mg zinc).

Sugar Free Tablets: Completely dissolve one Cold-EEZE Sugar Free tablet in your mouth. DO NOT CHEW OR SWALLOW TABLETS WHOLE. Repeat every hour as needed. Recommended daily dosage is 16 tablets per day.

Can I take other medicines while taking Cold-EEZE?
While Cold-EEZE can be safely taken with most other medications, including other cough/cold products, you should always inform your healthcare provider that you are taking Cold-EEZE or any other medications. Because zinc is a trace mineral, it has been reported to make doxycycline, minocycline tetracycline as well as Coumadin less effective. It may keep those drugs from absorbing effectively. If you are taking those drugs, your doctor may ask you to wait two hours after ingesting them before you use Cold-EEZE. Talk to your healthcare provider for more information.

How many grams of carbohydratesare in Cold-EEZE?
There are 4.5 g carbohydrates and 18 calories in each Cold-EEZE lozenge. Each Sugar Free Cold-EEZE Lozenge contains 2.24 g of carbohydrates and 9 calories. Sugar Free Cold-EEZE tablets contain 0 g of carbohydrates and 0 calories.

How much zinc is in a Cold-EEZE lozenge?
There are 13.3 mg of zinc in each lozenge. There is approximately 4.43 mg of zinc in each sugar free tablet.

Does Cold-EEZE contain gluten?
Cold-EEZE is a gluten-free product, and safe for people with Celiac disease.

What side effects can I expect from Cold-EEZE lozenges?
The most frequent side effect is a temporary change in taste. This occurs as a result of the availability of zinc ions in the mouth. A slightly metallic taste is absolutely normal and only temporary. Cold-EEZE is formulated with glycine to help minimize this aftertaste as well as ensure a sustained dwell time of the zinc ions when dissolved.

Mild stomach upset and nausea are also frequent side effects. Dissolve lozenges or tablets on a full stomach to prevent mild stomach upset. If stomach upset does occur despite using Cold-EEZE as directed, consult a physician.

There are no known side effects that pose any significant health risk when Cold-EEZE is used as directed.

Is Cold-EEZE safe for people with heart disease and high blood pressure?
Unlike many decongestants available on the market, Cold-EEZE does not contain any ingredients that have been shown to raise blood pressure and does not include warnings for people with heart disease, diabetes or hypertension.

Should I take antibiotics for my cold symptoms?
Antibiotics are not an appropriate treatment for colds or flu. According to the CDC, "While antibiotics should be used to treat bacterial infections, they are not effective against viral infections like the common cold, most sore throats and the flu. Overuse of antibiotics is jeopardizing the usefulness of essential drugs. Decreasing inappropriate antibiotic use is the best way to control resistance."

Preliminary research results indicate that only 3% of individuals (adolescents) who took Cold-EEZE required antibiotics versus 39.3% of individuals (adolescents) who did not take Cold-EEZE as a first line treatment for the common cold.

Is Cold-EEZE safe for kids?
Cold-EEZE has been studied and shown to be effective in adolescents and adults (aged 12 years and over). Cold-EEZE does not have studies confirming effectiveness and safety for children under the age of 12. As with all treatments for your child, the best source of information is your pediatrician. Consult with your pediatrician before giving your child this or any other medication.

Is Cold-EEZE safe for pregnant women?
The recommended daily allowance for zinc increases during pregnancy from 12 mg to 25 mg per day. A daily dosage of (6) six Cold-EEZE lozenges delivers 80 mg of elemental zinc. As pre-natal vitamins contain elevated dosages of zinc, and a normal 2000-calorie diet delivers approximately 10 mg of zinc per day, the addition of as few as (1) one or (2) two Cold-EEZE lozenges (13.3 mg each) may exceed upper limits for daily intake of approximately 40 mg. If you are pregnant or breast feeding, ask a health professional before use. Your OB/GYN will have guidelines for which cough/cold products he or she recommends. Please refer to their recommendations.

Is Cold-EEZE safe for people with diabetes?
Sugar-Free Cold-EEZE has been shown in a clinical study not to adversely affect the blood sugar of type 1 and type 2 diabetics. The study was conducted at the Diabetes and Glandular Disease Clinic in San Antonio, Texas. It was published in the Journal of American Therapeutics.

Does Cold-EEZE have an expiration date?
The numbers on the side of your box of Cold-EEZE are lot numbers used specifically for internal tracking purposes and do not indicate a date. Cold-EEZE lozenges are homeopathic and therefore not required to carry an expiration date.