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Celadrin Cream
by Doctors Best
2 oz. Cream
Topical Nutritional Support For Inflammation*
Our Price: $7.76
Retail Price: $15.99
You Save: $8.23 each, a 51% Savings! | 
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Celadrin Cream is a unique formulation of esterified (stable) fatty acids that has been shown to reduce certain effects related to pronounced inflammatory processes that can occur in the body. Being a complex molecule consisting of various fatty acids, it is able to penetrate cell membranes, which enhances membrane permeability and cell-to-cell signaling. In doing so, Celadrin may reduce the level of inflammatory components of the immune system from binding to cells and thus causing occasional inflammation in different parts of the body.* Benefits of Topical Celadrin Cream
Celadrin Cream can be an effective option for topical joint pain relief. Celadrin fatty acid esters combined with 1.25% USP grade natural menthol provides minor pain relief for sore muscles, joints and the surrounding areas. When applied topically, Celadrin is well-absorbed and can act locally to help maintain joint comfort and increase the range of motion of joints.* Studies have confirmed the benefits of topical applications of the cream directly to sore joints. In a double-blind placebo-controlled trial published in the Journal of Rheumatology in 2004, forty individuals with sore knee joints participated.Twenty patients were given Celadrin Cream and 20 others were assigned a placebo cream to be applied topically twice daily for 30 days. Participants were assessed on various orthopedic measures of improvement. At the end of the study, the researchers noted that the Celadrin Cream was an effective treatment for improving knee ROM, ability to ascend/descend stairs, ability to rise from sitting, ability to walk and sit down, and unilateral balance. No changes were seen in the placebo group.* A second study was conducted by the same group of researchers using a cream consisting of Celadrin and menthol. In this trial, participants who had significant functional performance deficiencies of elbow, knee or wrist joints were given the cream and asked to apply it twice daily for one week. Measure of comfort and performance were reassessed before the treatment and again after one week. The researchers found significant improvement with the use of the cream. Overall, there was a significant improvement in joint range of motion, comfort levels, muscular endurance and joint function. Even in the relatively short period of this trial (only 1 week), the cream was deemed to be effective for enhancing joint function in these participants.*
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Supplement Facts | | | | Amount
Per Serving | Daily
Value | Celadrin
(A proprietary blend of esterified fatty acid carbons (EFAC), including cetyl myristate, cetyl myristoleate, cetyl laurate, cetyl oleate, and cetyl palmitoleate) | | ** | Menthol
(1.25 percent) Topical Analgesic | | ** | A Proprietary Blend
In a base of:
Benzyl Alcohol, Glycerin, Glyceryl Stearate, Mentha Piperita (Peppermint Oil), Olea Europaea (Olive) Fruit Oil, PEG 100 Stearate, Cetyl Alcohol, Phenoxyethanol, Chlorphenesin, Benzoic Acid, Butylene Glycol, Sorbic Acid, Cetearyl Alcohol, Carbomer, Alpha Tocopherol Acetate (Vitamin E), Lecithin, Potassium Hydroxide | | ** | |
** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet. |
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| As a transdermal dietary supplement, one-fourth (1/4) teaspoon topically one to three (1-3) times per day, or more as directed by your healthcare practitioner. |
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| For external use only. Avoid contact with eyes. ... If condition worsens, or if symptoms persist for more than seven (7) days/clear up and occur again within a few days, discontinue use of product and consult a physician. ... Do not apply to wounds or damaged skin. ... Do not bandage tightly. ... Keep out of reach with children. ... If swallowed, get medical help or contact a poison control center immediately. ... Store in a cool, dry place. |
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| Contains nothing other than the ingredients listed. |
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| Endurance, Inflammation Nutrition, Joint Comfort, Joint Health, Joint Mobility, Muscle Aches, Muscle Fatigue, Swollen Joints |
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| Ankle, Connective Tissue, Elbow, Finger, Hip, Joints, Knee, Toes, Wrist |
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We firmly believe that the integration of scientific research and traditional wisdom is how nutritional and herbal supplements will reach their exciting potential. Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Careful research and precise formula development keeps us at the leading edge of quality, effectiveness, and innovation. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Countless hours have been spent analyzing scientific literature to provide sound alternatives to the proliferation of questionable supplements in the marketplace. Each Doctor's Best product is accompanied by an annotated "Fact Sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with the FDA in accordance with DSHEA regulations. Traditional wisdom, up-to-date research, product quality you can trust: everything you need to develop smart strategies for achieving optimal health and well-being. We think you’ll agree that this combination of products and services is second to none. |
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Q. What are your capsules made of?
A. Doctor's Best capsules are typical gelatin capsules, with the exception of select products now available in veggie cap form. They are made of gelatin from cattle, like the familiar "Knox gelatin" sold in grocery stores.
The gelatin used to make Doctor's Best's capsules is manufactured in accordance with strict guidelines that ensure it is BSE-free. The FDA and the supplement industry approved these guidelines. The gelatin is made only from cattle living in non-BSE countries. All Doctor's Best capsules are in full compliance with the FDA's September 1997 industry guide, The Sourcing and Processing of Gelatin to Reduce the Potential Risk Posed by Bovine Spongiform Encephalopathy in FDA-Regulated Products for Human Use.
Q. How long does it take for a capsule to dissolve?
A. Approximately 30-45 minutes. For 2-piece gelatin capsule, the USP standard for maximum dissolution time is 45 minutes.
Q. How long does it take for a tablet to dissolve?
A. FDA Rules & Regulations require tablets to dissolve in 45 minutes or less. However, Doctor's Best sets its standards higher. They require that their tablets dissolve in 30 minutes or less. Every lot of products in tablet form is tested to verify that it dissolves in under 30 minutes.
Q. Can I find out how fast a capsule or tablet dissolves by dropping it in a glass of water or vinegar at home?
A. Testing dissolution times at home using vinegar is not an accurate way to learn what happens to capsules and tablets in your stomach. Because stomach acid is much stronger than vinegar, capsules and tablets dissolve much faster in the stomach than in a glass of water or vinegar. Also, the stomach continually "agitates" its contents, much like a washing machine does. |
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Q. Who determines what the daily dosage should be? And how is this done?
A. A panel of scientists at The Natural Academy of Sciences performs extensive research, ongoing clinical studies and scientific testing in order to determine the RDI (Recommended Daily Intake).
Q. I see that Silicon Dioxide has been used as an excipient in some of your products. Should I be concerned?
A. Silicon Dioxide is a GRAS (Generally Recognized As Safe) food additive. Numerous studies have found the following:
The oral toxicity for humans would be greater than 350 grams in one dose based on allometric comparisons between the mice studied and humans.
A single dose of 2,500mg of amorphous polymeric silicon dioxide to human volunteers did not significantly raise the SiO2 excretion in the urine. This suggests poor absorption of silicon dioxide (Langendorf 1966).
Less than one one-hundredth (1/100th) of the dose was found in urine, suggesting extremely poor absorption (Langendorf 1966).
This would suggest that there is no scientific reason to eliminate silicon dioxide as an excipient at the very low levels found in dietary supplements.
Q. Why is silicon dioxide used as an excipient in Doctor’s Best products? Why are excipients used at all?
A. Silicon Dioxide is used as a flow agent to enable "sticky" substances to flow through the encapsulation equipment. If silicon dioxide were not used, other flow agents would have to be used which would actually increase the number of excipients found in a given product. Ideally, the fewer excipients used, the better.
Q. Is there a limit to how many vitamins can be taken safely in one day?
A. Our bodies need vitamins and minerals, and if taken in large amounts, vitamins and minerals can adversely affect health. Large amounts of anything can be toxic. Our best advice is to work with a nutritionally aware doctor and follow label directions. |
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1. Hesslink R Jr., et al. Cetylated fatty acids improve knee function in patients with osteoarthritis. J Rheumatology 2002;8:1708-1712.
2. Anonymous. Monograph: Glucosamine sulfate. Alt Med Review 1999;4:3;193-195.
3. Kraemer WJ, et al. Effect of a cetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis. J Rheumatology 2004;4:767-74.
4. Crolle G, D'Este E. Glucosamine sulphate for the management of arthrosis: a controlled clinical evaluation. Curr Med Res Opin 1980;7:104-109.
5. Rovati LC. Clinical research in osteoarthritis: design and results of short-term and long-term trials with disease modifying drugs. Int J Tissue React 1992;14:243-51.
Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.
6. Bassleer C, et al. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis and Cartilage 1998;6:427-434. Med. 2002 Oct 14;162(18):2113-23.
7. Reginster JY, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet 2001;357:251-56.
8. Macario, J. T., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68.
9. Kraemer WJ, et al. Effect of acetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis. J Rheumatol.2004 Apr;31(4):767-74.
10. Kraemer WJ,et al. Acetylated fatty acid topical cream with menthol reduces pain and improves functional performance in individuals with arthritis. J Strength Cond Res.2005 May;19(2):475-80. |
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Our Price: $7.76
Retail Price: $15.99
You Save: $8.23 each, a 51% Savings! |
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