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Celadrin Complex With Glucosamine
by Doctors Best
90 Tablets
Nutritionally Reduces Effects Of Inflammation*
Our Price: $12.84
Retail Price: $34.99
You Save: $22.15 each, a 63% Savings! | 
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Celadrin is a unique formulation of esterified (stable) fatty acids that has been shown to reduce certain effects related to pronounced inflammatory processes that can occur in the body. Being a complex molecule consisting of various fatty acids, it is able to penetrate cell membranes, which enhances membrane permeability and cell-to-cell signaling. In doing so, Celadrin may reduce the level of inflammatory components of the immune system from binding to cells and thus causing occasional inflammation in different parts of the body.* Glucosamine Sulfate
Glucosamine sulfate is the most completely studied form of glucosamine. It is commonly derived from the exoskeleton of shellfish and is a critical nutrient needed for the synthesis and repair of joint cartilage. Glucosamine sulfate has the ability to stimulate the synthesis of glycosaminoglycans and other components of the structural matrix of joint tissue. Because of the comprehensive nature of glucosamine sulfate's effects, it may play a role in maintaining the health of joint tissues.* Increased Range of Motion in Joints*
Research has shown that Celadrin can have an impact on improving the range of motion in joints. A placebo-controlled trial conducted in 2002 showed that those individuals taking a complex containing Celadrin for 2 months had a significant improvement in knee flexion (ability to bend the knee) over those taking a placebo.* Another study conducted on Celadrin published in 2004 concluded that treatment “significantly increased physical performance (as measured by a variety of orthopedic tests)” in patients with compromised knee mobility. The study found that the subjects given Celadrin showed improvement in their ability to climb stairs, rise from a chair and walk, along with an improved sense of balance, strength and endurance.* Maintains Joint Comfort*
The anti-inflammatory actions of Celadrin have been demonstrated by one double-blind, placebo controlled trial which showed Celadrin, when taken orally at recommended intake levels, decreased pain scores and increased walking distance compared to the group receiving placebo. The authors theorize that Celadrin may work by down-regulating the effect of certain precursors of the body’s inflammatory response.*
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Supplement FactsServing Size: One (1) Tablet
Servings Per Container: 90 | | | | Amount
Per Serving | Daily
Value | Glucosamine
(As Glucosamine Sulfate KCI) | 500 mg | ** | Celadrin
(a proprietary blend of esterified fatty acid carbons of myristate, myristoleate, laurate, oleate, palmitate, and palmitoleate with tapioca) | 500 mg | ** | |
** Daily Value Not Established. Percent Daily Values are based on a 2,000 calorie diet. |
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| Cellulose, Croscarmellose Sodium, Silicon Dioxide |
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| As a dietary supplement, one (1) tablet three (3) times daily with or without food, or more as directed by your healthcare practitioner. |
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| If pregnant or nursing, consult your healthcare provider before taking this, or any, supplement. ... Keep out of reach of children. ... Store in a cool, dry place. |
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| Doctors Best products do not contain milk, egg, wheat, yeast, corn, sugar, sweeteners, starch, salt, preservatives, waxes, coating or colors. Doctor's Best products are also GLUTEN FREE. Contains products derived from SHELLFISH. |
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| Endurance, Immune System Support, Inflammation Nutrition, Joint Comfort, Joint Health, Joint Mobility, Swollen Joints |
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| Ankle, Cartilage, Connective Tissue, Elbow, Finger, Hip, Immune System, Joints, Knee, Membrane, Toes, Wrist |
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| Exasperated |
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Q. What is the source of Celadrin (a proprietary blend of esterified fatty acids)?
A. Beef tallow.
Q. I take your Best Glucosamine product with good results. But I'm curious about Celadrin. What's better about it?
A. Celadrin is a complex of fatty acids that can affect the expression of certain cytokines that mediate occasional inflammation in the joints and other tissues. In this way, Celadrin actually complements the actions of glucosamine, which is a necessary building block for joint and cartilage tissue. Together, Celadrin and glucosamine provide an effective means to maintain the health and integrity of joint tissue. |
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We firmly believe that the integration of scientific research and traditional wisdom is how nutritional and herbal supplements will reach their exciting potential. Founded in 1990 by a pioneering physician committed to science-based alternative health care, Doctor’s Best offers only the most important nutritional supplements. Careful research and precise formula development keeps us at the leading edge of quality, effectiveness, and innovation. Containing the finest quality raw materials from around the world, Doctor’s Best supplements embody the best that traditional knowledge and current scientific research have to offer in the field of therapeutic nutrition. Countless hours have been spent analyzing scientific literature to provide sound alternatives to the proliferation of questionable supplements in the marketplace. Each Doctor's Best product is accompanied by an annotated "Fact Sheet" with detailed background information, structure-function statements, and scientific references that substantiate these statements. All structure-function statements have been filed with the FDA in accordance with DSHEA regulations. Traditional wisdom, up-to-date research, product quality you can trust: everything you need to develop smart strategies for achieving optimal health and well-being. We think you’ll agree that this combination of products and services is second to none. |
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Q. What are your capsules made of?
A. Doctor's Best capsules are typical gelatin capsules, with the exception of select products now available in veggie cap form. They are made of gelatin from cattle, like the familiar "Knox gelatin" sold in grocery stores.
The gelatin used to make Doctor's Best's capsules is manufactured in accordance with strict guidelines that ensure it is BSE-free. The FDA and the supplement industry approved these guidelines. The gelatin is made only from cattle living in non-BSE countries. All Doctor's Best capsules are in full compliance with the FDA's September 1997 industry guide, The Sourcing and Processing of Gelatin to Reduce the Potential Risk Posed by Bovine Spongiform Encephalopathy in FDA-Regulated Products for Human Use.
Q. How long does it take for a capsule to dissolve?
A. Approximately 30-45 minutes. For 2-piece gelatin capsule, the USP standard for maximum dissolution time is 45 minutes.
Q. How long does it take for a tablet to dissolve?
A. FDA Rules & Regulations require tablets to dissolve in 45 minutes or less. However, Doctor's Best sets its standards higher. They require that their tablets dissolve in 30 minutes or less. Every lot of products in tablet form is tested to verify that it dissolves in under 30 minutes.
Q. Can I find out how fast a capsule or tablet dissolves by dropping it in a glass of water or vinegar at home?
A. Testing dissolution times at home using vinegar is not an accurate way to learn what happens to capsules and tablets in your stomach. Because stomach acid is much stronger than vinegar, capsules and tablets dissolve much faster in the stomach than in a glass of water or vinegar. Also, the stomach continually "agitates" its contents, much like a washing machine does. |
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Q. Who determines what the daily dosage should be? And how is this done?
A. A panel of scientists at The Natural Academy of Sciences performs extensive research, ongoing clinical studies and scientific testing in order to determine the RDI (Recommended Daily Intake).
Q. I see that Silicon Dioxide has been used as an excipient in some of your products. Should I be concerned?
A. Silicon Dioxide is a GRAS (Generally Recognized As Safe) food additive. Numerous studies have found the following:
The oral toxicity for humans would be greater than 350 grams in one dose based on allometric comparisons between the mice studied and humans.
A single dose of 2,500mg of amorphous polymeric silicon dioxide to human volunteers did not significantly raise the SiO2 excretion in the urine. This suggests poor absorption of silicon dioxide (Langendorf 1966).
Less than one one-hundredth (1/100th) of the dose was found in urine, suggesting extremely poor absorption (Langendorf 1966).
This would suggest that there is no scientific reason to eliminate silicon dioxide as an excipient at the very low levels found in dietary supplements.
Q. Why is silicon dioxide used as an excipient in Doctor’s Best products? Why are excipients used at all?
A. Silicon Dioxide is used as a flow agent to enable "sticky" substances to flow through the encapsulation equipment. If silicon dioxide were not used, other flow agents would have to be used which would actually increase the number of excipients found in a given product. Ideally, the fewer excipients used, the better.
Q. Is there a limit to how many vitamins can be taken safely in one day?
A. Our bodies need vitamins and minerals, and if taken in large amounts, vitamins and minerals can adversely affect health. Large amounts of anything can be toxic. Our best advice is to work with a nutritionally aware doctor and follow label directions. |
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1.Hesslink R Jr., et al. Cetylated fatty acids improve knee function in patients with osteoarthritis. J Rheumatology 2002;8:1708-1712.
2.Anonymous. Monograph: Glucosamine sulfate. Alt Med Review 1999;4:3;193-195.
3.Kraemer WJ, et al. Effect of a cetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis. J Rheumatology 2004;4:767-74.
4.Crolle G, D'Este E. Glucosamine sulphate for the management of arthrosis: a controlled clinical evaluation. Curr Med Res Opin 1980;7:104-109.
5.Rovati LC. Clinical research in osteoarthritis: design and results of short-term and long-term trials with disease modifying drugs. Int J Tissue React 1992;14:243-51.
Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.
6.Bassleer C, et al. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis and Cartilage 1998;6:427-434.
Med. 2002 Oct 14;162(18):2113-23.
8.Macario , J. T., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal . Pharmatherpeutica 1982; 3(3):157-68. |
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Our Price: $12.84
Retail Price: $34.99
You Save: $22.15 each, a 63% Savings! |
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