Supplement Facts

Chronic health conditions such as high blood pressure, obesity, diabetes, and heart disease have become so common that most people don't remember what it's like to be in perfect health. And if they're not feeling their best, they can't be their best.

In truth, many chronic health conditions are preventable. They're the result of years of poor eating habits, lack of exercise, and prolonged exposure to stress. And leading health organizations now tell us that by returning to a healthier lifestyle—by getting the right nutrients, becoming active, and managing the stressors in life— these conditions can be managed, prevented, or even reversed.

The solution seems so simple, yet the incidence of chronic illness continues to rise at an alarming rate. At Metagenics, they're aiming to change all that.

Addressing Chronic Illness with Therapeutic Lifestyle Changes
Metagenics' groundbreaking Therapeutic Lifestyle Change (TLC) programs have helped tens of thousands of chronic illness sufferers all over the world regain their health so they can once again enjoy their lives to the fullest. No quick, short term fixes; these programs work because they're focused on helping people develop healthy, life-long habits they can easily incorporate into their busy schedules. Metagenics' TLC programs are available only from specially trained, licensed health care professionals—the people qualified to recommend and tailor a regimen that's unique to each individual's needs.

Patient Success Depends on Provider Success
Let's face it. Most doctors' offices have neither the time nor the expertise to provide the individualized lifestyle counseling that's necessary to effect real change. In designing the TLC program, Metagenics asked health care providers to tell them what it would take to implement TLC successfully in their practice. The answer was teamwork—getting support staff involved, enlisting practice extenders, and ensuring smooth office flow. Today, providers who implement Metagenics' TLC programs overwhelmingly report they're busier and more successful than ever in helping patients achieve their desired health outcomes.

Addressing the Root Cause of Illness through Science-Based Nutrition
Back in 1983, Metagenics had a big idea: the right nutrition could help people realize their best health by positively influencing what makes them unique—their genes. They called it realizing "genetic potential" for good health. Today, it's known as the science of nutrigenomics—the study of food as one of the most important environmental modifiers of gene expression in determining health and disease patterns. Through substantial and ongoing commitment to nutrigenomic research, Metagenics has been able to identify natural compounds with powerful therapeutic applications, to be used in their science-based TLC programs, medical foods, and nutraceuticals.

Setting the Standard in Research, Quality & Innovation
Knowing that professionals rely on them to make people feel better isn't something Metagenics takes lightly. It's the reason they lead the industry in research, professional education, and quality manufacturing. But they're also brave enough to search for the next big thing to make an even greater impact on health. The result? An impressive list of patented formulas and ingredients, and a revolutionary product development process to help make natural approaches even safer and more effective.

Whether you're a patient or a health care provider, be your best with Metagenics!

• FirstLine Therapy—their turnkey, clinically tested therapeutic lifestyle programs
• One of the largest and most diverse research and development teams in the natural products industry
• Leading-edge nutritional genomics and clinical research facilities
• State-of-the-art biotechnology instrumentation
• A unique product development model assuring predicted safety, efficacy, and bioavailability
  

The Best and Brightest Minds and Ideas at Work
The cornerstone of research and development at Metagenics is MetaProteomics, LLC, their wholly-owned biotechnology subsidiary. Established in 2002, MetaProteomics houses state-of-the-art technology and is home to one of the largest and most diverse scientific staffs in the natural products industry.

Clinical Focus Areas
The MetaProteomics team—including top notch phytochemists, biochemists, MDs, RNs, registered dietitians, nutritionists, and other highly respected researchers and clinicians—shares a collective sense of urgency when it comes to finding the most effective natural ingredients/ingredient combinations to be developed into Metagenics' medical food and nutraceutical formulas. Their work has culminated in a line of high quality, science based formulas that effectively address:

• Cardiovascular health
• Blood sugar concerns
• Gastrointestinal health
• Immune health
• Joint issues
• Women's health
• Men's health
• Musculoskeletal health
• Neurological health
• Stress management
• Detoxification
• Foundation Nutrition
  

So far, MetaProteomics discoveries have resulted in more than 230 domestic and international patents awarded and pending—a feat no other company in the industry niche can boast.

A Unique Product Development Model
The MetaProteomics product development platform is called the ExpresSyn Process. This proprietary process—designed to ensure the effectiveness and predicted safety of Metagenics' nutritional formulas—combines the best of medical, biotechnology, and pharmacological discovery techniques and Metagenics' in-depth knowledge of natural ingredients.

The ExpresSyn Process involves the following processes:

• Ingredient Discovery. The health-supporting properties of hundreds of natural compounds and compound mixtures derived from foods, spices, and herbs with a long history of safe use are identified via in vitro enzyme assays, cell culture models, and other forms of testing.
• Proof of Concept. Additional testing is conducted to provide preliminary confirmation of the desired clinical target. The formulas with acceptable safety profiles at therapeutic doses are evaluated for bioavailability and metabolism in humans.
• Formula development. A source-safe pipeline of natural ingredients is identified, then products are formulated in the form (tablet, soft gel, or bar) that's most appropriate for the therapeutic target.
• Clinical experience. The new formula is evaluated for effectiveness using observational studies and random controlled studies.
  

A Promising New Therapeutic Agent: Selective Kinase Response Modulators (SKRMs)
A key MetaProteomics discovery is the existence and mechanism of highly specialized bioactive molecules known as selective kinase response modulators, or SKRMs. Metagenics' research identified SKRMs derived from plant-based compounds as having the ability to modulate specific cell signaling pathways, which may play a role in chronic illness. This mechanism of action is exciting in thatit's different from any other class of therapeutics.*

SKRMs derived from hops (Humulus lupulus L.), acacia (Acacia nilotica), and other phytocompounds have been successfully incorporated into Metagenics formulas to address:

• Chronic inflammation
• Minor pain
• Glucose balance
  
• Metabolic syndrome
• Bone remodeling

At Metagenics, we take pride in our extensive research efforts. In addition to conducting the most innovative laboratory research in their niche, their clinicians carefully and thoroughly document the effectiveness of their nutraceuticals, medical foods, and therapeutic lifestyle change (TLC) programs work in real patients, to improve health and reverse chronic illness. The results of this work are routinely published in peer-reviewed journals.

No other company in this segment can offer this kind of supporting evidence of effective use in a clinical setting.

Clinical studies and individual case management studies are conducted at Metagenics' Functional Medicine Research Center (FMRC)—the clinical research arm of Metagenics. Located on the site of their Gig Harbor, Washington campus and staffed by doctors, dietitians, nutritionists, and other clinicians, the FMRC is responsible for investigating and developing treatment approaches to chronic health conditions using TLC, nutritional products, and other natural therapies. Many of Metagenics' nutritional formulas in development are tested here.

More than 2,000 patient visits take place annually at the FMRC, as part of:

• Clinical studies to assess the impact of specific nutritional and TLC interventions
• Individual case management studies (ICMs) that expand research and understanding

In addition to FMRC clinical research, Metagenics medical professionals reach out to other organizations and universities for new research opportunities. By combining efforts with other renowned researchers to design and implement clinical studies, Metagenics is able to conduct more leading-edge research than ever before.